Transplantation characteristics of European patients undergoing hematopoietic stem cell transplantation for CD40 ligand deficiency; nonsurvivors
Case . | Age at Tx, y . | Donor . | T-cell depletion . | Conditioning . | GvHD . | Cause of death . |
|---|---|---|---|---|---|---|
| 1 | 1 | MUD | Nil | bu/cy/ATG | Nil | CMV |
| 11 | 4 | MUD+ | Nil | bu/cy/CIH | 3 S, G | Adenovirus/GvHD |
| 15 | 7 | MUD | CD34+ | bu/cy/ATG | Nil | Aspergillus |
| 24 | 10 | MSD | Nil | flu/mel | Nil | Cp |
| 27 | 11.5 | MUD | Nil | bu/cy/LFA-1/CD2 | 2 S, L | Cp/aspergillus/adenovirus |
| 28 | 11.5 | MSD | Nil | bu/cy | Nil | CMV |
| 29 | 13 | MUD+ | Campath | bu/cy/ATG | Nil | Cp |
| 30 | 13 | MSD | Nil | bu/cy | 3 S, L | Cp |
| 32 | 14 | MSD | Nil | flu/mel/ATG | 4 L | Cp/GvHD |
| 35 | 16 | MUD+ | CD+ | Flu/mel/ATG/TLI | 2 S | Aspergillus |
| 36 | 16.5 | MUD+ | CD34+ | cy/TBI | 1 S | Cp/graft rejection/liver failure, LT |
| 38 | 19 | MSD | Nil | bu/cy | 3 S, G, L | CMV/GvHD |
Case . | Age at Tx, y . | Donor . | T-cell depletion . | Conditioning . | GvHD . | Cause of death . |
|---|---|---|---|---|---|---|
| 1 | 1 | MUD | Nil | bu/cy/ATG | Nil | CMV |
| 11 | 4 | MUD+ | Nil | bu/cy/CIH | 3 S, G | Adenovirus/GvHD |
| 15 | 7 | MUD | CD34+ | bu/cy/ATG | Nil | Aspergillus |
| 24 | 10 | MSD | Nil | flu/mel | Nil | Cp |
| 27 | 11.5 | MUD | Nil | bu/cy/LFA-1/CD2 | 2 S, L | Cp/aspergillus/adenovirus |
| 28 | 11.5 | MSD | Nil | bu/cy | Nil | CMV |
| 29 | 13 | MUD+ | Campath | bu/cy/ATG | Nil | Cp |
| 30 | 13 | MSD | Nil | bu/cy | 3 S, L | Cp |
| 32 | 14 | MSD | Nil | flu/mel/ATG | 4 L | Cp/GvHD |
| 35 | 16 | MUD+ | CD+ | Flu/mel/ATG/TLI | 2 S | Aspergillus |
| 36 | 16.5 | MUD+ | CD34+ | cy/TBI | 1 S | Cp/graft rejection/liver failure, LT |
| 38 | 19 | MSD | Nil | bu/cy | 3 S, G, L | CMV/GvHD |
GvHD indicates graft versus host disease grades 1 to 4; MUD, matched unrelated donor 10/10; bu, busulphan; cy, cyclophosphamide; ATG, rabbit antithymocyte globulin; CMV, cytomegalovirus; MUD+, matched unrelated donor less than 10 of 10; CIH, alemtuzumab; S, skin; G, gut; MSD, matched sibling donor; flu, fludarabine; mel, melphalan; Cp, Cryptosporidium parvum; LFA-1, anti-LFA-1 antibody; CD2, anti-CD2 antibody; L, liver; Campath, CAMPATH-1M; TLI, total lymphoid irradiation; TBI, total body irradiation; and LT, liver transplantation.