Stroke incidence, reticulocytosis, and RBC adhesion to TSP and LM
Age and genotype . | Retic %* . | % Cerebral infarction† . | RBC adhesion to TSP, cells/mm2‡ . | RBC adhesion to LM, cells/mm2‡ . |
|---|---|---|---|---|
| Adult mice, older than 12 wk old | ||||
| ++, wild-type§ | 2 | 0 | 19.0 ± 4.0 (18) | 3.1 ± 1.4 (10) |
| Hi-retic +/+ | 30 | 0 | 18.5 ± 3.5 (5) | 7.4 ± 1.6 (5) |
| sphJ/sphJ | 95 | 75 | 1105.8 ± 67.5 (7) | 122.3 ± 23.1 (7) |
| sph2BC/sph2BC | 90 | 90 | 899.0 ± 127.9 (9) | 94.9 ± 14.9 (10) |
| sph/sph, 12-24 wk | 95 | 100 | 708.7 ± 38.6 (29) | 170.2 ± 20.9 (15) |
| sph/sph, 12-16 wk | 95 | 100 | 696.4 ± 49.9 (15) | 172.5 ± 33.2 (7) |
| sph/sph, 20-24 wk | 95 | 100 | 721.8 ± 61.9 (14) | 168.1 ± 29.6 (8) |
| sphDem/sphDem, 12-24 wk | 50 | 70 | 798.9 ± 113.3 (10) | 53.4 ± 11.0 (7) |
| sphDem/sphDem, 12-16 wk | 50 | 66 | 859.9 ± 177.7 (6) | 46.8 ± 8.2 (4) |
| sphDem/sphDem, 20-24 wk | 50 | 75 | 707.4 ± 134.9 (4) | 62.3 ± 25.3 (3) |
| Young mice (3-8 wk old) | ||||
| sph/sph, 3-4 wk | ND | 0 | 1069.6 ± 79.7 (7) | ND |
| sph/sph, 6-8 wk | ND | 37.5 | 1261.6 ± 79.8 (8) | ND |
| sphDem/sphDem, 3-4 wk | ND | 25 | 959.7 ± 115.6 (8) | ND |
| sphDem/sphDem, 6-8 wk | ND | 33 | 954.3 ± 43.7 (6) | ND |
Age and genotype . | Retic %* . | % Cerebral infarction† . | RBC adhesion to TSP, cells/mm2‡ . | RBC adhesion to LM, cells/mm2‡ . |
|---|---|---|---|---|
| Adult mice, older than 12 wk old | ||||
| ++, wild-type§ | 2 | 0 | 19.0 ± 4.0 (18) | 3.1 ± 1.4 (10) |
| Hi-retic +/+ | 30 | 0 | 18.5 ± 3.5 (5) | 7.4 ± 1.6 (5) |
| sphJ/sphJ | 95 | 75 | 1105.8 ± 67.5 (7) | 122.3 ± 23.1 (7) |
| sph2BC/sph2BC | 90 | 90 | 899.0 ± 127.9 (9) | 94.9 ± 14.9 (10) |
| sph/sph, 12-24 wk | 95 | 100 | 708.7 ± 38.6 (29) | 170.2 ± 20.9 (15) |
| sph/sph, 12-16 wk | 95 | 100 | 696.4 ± 49.9 (15) | 172.5 ± 33.2 (7) |
| sph/sph, 20-24 wk | 95 | 100 | 721.8 ± 61.9 (14) | 168.1 ± 29.6 (8) |
| sphDem/sphDem, 12-24 wk | 50 | 70 | 798.9 ± 113.3 (10) | 53.4 ± 11.0 (7) |
| sphDem/sphDem, 12-16 wk | 50 | 66 | 859.9 ± 177.7 (6) | 46.8 ± 8.2 (4) |
| sphDem/sphDem, 20-24 wk | 50 | 75 | 707.4 ± 134.9 (4) | 62.3 ± 25.3 (3) |
| Young mice (3-8 wk old) | ||||
| sph/sph, 3-4 wk | ND | 0 | 1069.6 ± 79.7 (7) | ND |
| sph/sph, 6-8 wk | ND | 37.5 | 1261.6 ± 79.8 (8) | ND |
| sphDem/sphDem, 3-4 wk | ND | 25 | 959.7 ± 115.6 (8) | ND |
| sphDem/sphDem, 6-8 wk | ND | 33 | 954.3 ± 43.7 (6) | ND |
Retic indicates reticulocyte; and ND, not done.
Reticulocyte counts published in references 14 and 22 .
Percent cerebral infarction derived from a separate cohort of mice for sphJ/sphJ and sph2BC/sph2BC but from the same cohort of mice used in adhesion experiments in this study for all other groups.
Mean ± SEM; numbers in parentheses indicate number of measurements; P values are found in Figure 1.
WBB6F1-+/+ mice; data is similar for WBB6F1-sph/+, and CcS3/Dem-+/+ and -sphDem/+ mice.