Clinical course of children with TRCA episodes associated with HPV B19
. | Total population, N = 68 . | SCD-SS,*N = 47 . | SCD-SC,*N = 14 . | Other,†N = 7 . | p* . |
|---|---|---|---|---|---|
| Chief complaint, % | |||||
| Fever | 42.7 | 51.1 | 35.7 | 0 | NS |
| Pain | 39.7 | 25.5 | 57.1 | 100 | .049 |
| Pallor | 5.9 | 4.4 | 7.1 | 0 | NS |
| Laboratory findings | |||||
| Median initial Hb level, g/dL | 5.8 | 5.0 | 8.1 | 8.0 | < .0001 |
| Median initial reticulocyte, % | 1.0 | 1.2 | 0.4 | 0.7 | NS |
| Median lowest Hb level, g/dL | 4.8 | 4.5 | 5.6 | 7.6 | .0002 |
| Median lowest reticulocyte, % | 0.6 | 0.7 | 0.3 | 0.7 | NS |
| Mean Δ hemoglobin level, g/dL (SD) | 4.1 (1.4) | 3.7 (1.0) | 5.4 (1.8) | 3.5 (0.8) | < .001 |
| Neutropenia, % | 17.9 | 21.3 | 15.4 | 0 | NS |
| Thrombocytopenia, % | 26.5 | 14.9 | 64.3 | 28.6 | .001 |
| SCD complications, % | |||||
| Painful episode | 61.8 | 46.8 | 92.9 | 100 | .002 |
| Acute chest syndrome | 11.8 | 6.4 | 28.6 | 14.3 | .042 |
| Acute splenic sequestration | 19.1 | 8.5 | 50.0 | 28.6 | .002 |
| Fever while hospitalized | 89.7 | 87.2 | 100.0 | 85.7 | NS |
| Management, % | |||||
| Transfusion for TRCA | 72.1 | 85.1 | 57.1 | 14.3 | .025 |
| Parenteral antibiotics | 88.2 | 85.1 | 100 | 85.7 | NS |
| Opioids | 51.5 | 36.1 | 78.6 | 100 | .007 |
| Mean days hospitalized (SD) | 4.5 (2.2) | 4.2 (1.8) | 5.7 (2.7) | 4.4 (±3.1) | .009 |
| PICU admission, % | 13.2 | 14.9 | 14.3 | 0 | NS |
| Negative HPV B19 serology at presentation, % | 16.2 | 23.4 | 0 | 0 | .054 |
. | Total population, N = 68 . | SCD-SS,*N = 47 . | SCD-SC,*N = 14 . | Other,†N = 7 . | p* . |
|---|---|---|---|---|---|
| Chief complaint, % | |||||
| Fever | 42.7 | 51.1 | 35.7 | 0 | NS |
| Pain | 39.7 | 25.5 | 57.1 | 100 | .049 |
| Pallor | 5.9 | 4.4 | 7.1 | 0 | NS |
| Laboratory findings | |||||
| Median initial Hb level, g/dL | 5.8 | 5.0 | 8.1 | 8.0 | < .0001 |
| Median initial reticulocyte, % | 1.0 | 1.2 | 0.4 | 0.7 | NS |
| Median lowest Hb level, g/dL | 4.8 | 4.5 | 5.6 | 7.6 | .0002 |
| Median lowest reticulocyte, % | 0.6 | 0.7 | 0.3 | 0.7 | NS |
| Mean Δ hemoglobin level, g/dL (SD) | 4.1 (1.4) | 3.7 (1.0) | 5.4 (1.8) | 3.5 (0.8) | < .001 |
| Neutropenia, % | 17.9 | 21.3 | 15.4 | 0 | NS |
| Thrombocytopenia, % | 26.5 | 14.9 | 64.3 | 28.6 | .001 |
| SCD complications, % | |||||
| Painful episode | 61.8 | 46.8 | 92.9 | 100 | .002 |
| Acute chest syndrome | 11.8 | 6.4 | 28.6 | 14.3 | .042 |
| Acute splenic sequestration | 19.1 | 8.5 | 50.0 | 28.6 | .002 |
| Fever while hospitalized | 89.7 | 87.2 | 100.0 | 85.7 | NS |
| Management, % | |||||
| Transfusion for TRCA | 72.1 | 85.1 | 57.1 | 14.3 | .025 |
| Parenteral antibiotics | 88.2 | 85.1 | 100 | 85.7 | NS |
| Opioids | 51.5 | 36.1 | 78.6 | 100 | .007 |
| Mean days hospitalized (SD) | 4.5 (2.2) | 4.2 (1.8) | 5.7 (2.7) | 4.4 (±3.1) | .009 |
| PICU admission, % | 13.2 | 14.9 | 14.3 | 0 | NS |
| Negative HPV B19 serology at presentation, % | 16.2 | 23.4 | 0 | 0 | .054 |
SCD indicates sickle cell disease; TRCA, transient red cell aplasia; HPV B19, human parvovirus B19; PICU, pediatric intensive care unit; NS, not significant.
Percentages and P values represent comparisons between SCD-SS and SCD-SC groups.
Category includes 2 patients with SCD-Sβ° and 5 patients with SCD-Sβ+.