Clinical characteristics of patient population
Patient no. . | Age, y . | Major clinical manifestations . | Prior therapy . |
---|---|---|---|
1 | 37 | Mucosal ulcerations, dermatitis anemia, thrombocytopenia, splenomegaly | Prednisone, hydroxyurea, IFN-α, anti-IL-5 antibody (SCH55700) |
2 | 51 | Mucosal ulcerations, dermatitis, splenomegaly | Prednisone, hydroxyurea, IFN-α, anti-IL-5 antibody (SCH55700) |
3 | 47 | Pulmonary fibrosis, dermatitis, splenomegaly | None |
4 | 36 | Splenomegaly | Hydroxyurea |
5 | 47 | Endomyocardial fibrosis, pulmonary fibrosis, dermatitis, splenomegaly | Prednisone, hydroxyurea, IFN-α, cyclosporin A |
6 | 29 | Endomyocardial fibrosis, peripheral neuropathy, splenomegaly | Prednisone, hydroxyurea |
7 | 33 | Endomyocardial fibrosis, hepatosplenomegaly | Imatinib mesylate (100 mg daily) |
8 | 30 | Myocarditis, sinusitis, obstructive pulmonary disease, splenomegaly | Prednisone, hydroxyurea |
Patient no. . | Age, y . | Major clinical manifestations . | Prior therapy . |
---|---|---|---|
1 | 37 | Mucosal ulcerations, dermatitis anemia, thrombocytopenia, splenomegaly | Prednisone, hydroxyurea, IFN-α, anti-IL-5 antibody (SCH55700) |
2 | 51 | Mucosal ulcerations, dermatitis, splenomegaly | Prednisone, hydroxyurea, IFN-α, anti-IL-5 antibody (SCH55700) |
3 | 47 | Pulmonary fibrosis, dermatitis, splenomegaly | None |
4 | 36 | Splenomegaly | Hydroxyurea |
5 | 47 | Endomyocardial fibrosis, pulmonary fibrosis, dermatitis, splenomegaly | Prednisone, hydroxyurea, IFN-α, cyclosporin A |
6 | 29 | Endomyocardial fibrosis, peripheral neuropathy, splenomegaly | Prednisone, hydroxyurea |
7 | 33 | Endomyocardial fibrosis, hepatosplenomegaly | Imatinib mesylate (100 mg daily) |
8 | 30 | Myocarditis, sinusitis, obstructive pulmonary disease, splenomegaly | Prednisone, hydroxyurea |