Summary of H pylori and ITP data: review of the literature
Source of data, first author . | Pts origin, mean (range) or median (SC) age, y . | No. of pts with ITP tested (no. with chronic ITP) . | No. of pts Hp+ (% of pts with ITP) . | Method(s) used to detect Hp . | Mean (SD) or median (range) plt count × 109/L in Hp+ pts at inclusion . | No. treated for Hp (no. with plts < 30 × 109/L) . | No. of pts whose Hp was eradicated (% of pts treated) . | Nos. of PR or CR in pts whose Hp was eradicated (%) . | Mean (SD) or median (range) follow-up time after treatment, mos . | Comments . |
|---|---|---|---|---|---|---|---|---|---|---|
| Gasbarrini | Italian 45 (±14) | 18 (NA) | 11 (61.1) | Breath test | 95 (±39) | 11 (0) | 8 (72.7) | 8/8 (100) | 4 (NA) | None of the patients had marked thrombocytopenia before eradication |
| Emilia | Italian 50 (17-89) | 30 (30) | 13 (43.3) | Breath test, histol | 53 (±23.5) | 13 (3) | 12 (92.3) | 6/12 (50) | 8.3 (6-12) | Hp was more frequent in men. In an updated follow-up4 (median of 31.1 mos), 1 patient relapsed. |
| Veneri | Italian (NA) | 35 (NA) | 25 (71.4) | Breath test, histol | 51 (±28) | 16 (4) | 15 (93.6) | 11/15 (73.3) | 11.7 (6-28) | Two patients with severe chronic ITP responded. |
| Kohda | Japanese 52.7 (24-80) | 48 (40) | 25 (62.5) | Breath test, histol, serum Abs | 67 (±54) | 19 (NA) | 19 (100.0) | 12/19 (63) | 14.8 (9-39) | No change in plt count in Hp+ untreated patients. Six of 8 patients with refractory ITP responded. |
| Hashino | Japanese (NA) | 22 (22) | 14 (63.6) | Histol + culture | (NA) | 14 (NA) | 13 (82.9) | 5/13 (38.4) | 15 (NA) | One patient who had an initial complete response relapsed without Hp reinfection. |
| Hino | Japanese 54 (26-84) | 30 (25) | 21 (70.0) | Breath test, serum Abs | 32 (±19.75) | 21 (7) | 18 (85.7) | 10/18 (55.6) | NA | Three Hp- patients were treated without plt count increase. |
| Michel | French 40 (±19.8) | 51 (42) | 15 (29.4) | Serum Abs | 13 (1-50) | None treated | — | — | — | Hp prevalence was similar in controls. No differences were found between Hp+ and Hp- patients. The effect of eradication was not tested. |
| Jarque | Spanish (NA) | 56 (56) | 40 (71.4) | Breath test | 57 (±22) | 32 (NA) | 23 (71.9) | 3/23 (13) | Response assessed after 3 mos | Response rates were similar in Hp+ and Hp- patients. |
| This report | White, Hispanics 41 (± 18.3) | 74 (67) | 16 (21.6) | Breath test | 34 (10-54) | 15 (7) | 14 (93.3) | 1/14 (7) | 11.5 (3-18) | Eradication therapy also ineffective in 10 Hp- patients. |
| Total | — | 364 | 180 (49.5) | — | — | 141 | 122 (86.5) | 56/122 (46) | — | — |
Source of data, first author . | Pts origin, mean (range) or median (SC) age, y . | No. of pts with ITP tested (no. with chronic ITP) . | No. of pts Hp+ (% of pts with ITP) . | Method(s) used to detect Hp . | Mean (SD) or median (range) plt count × 109/L in Hp+ pts at inclusion . | No. treated for Hp (no. with plts < 30 × 109/L) . | No. of pts whose Hp was eradicated (% of pts treated) . | Nos. of PR or CR in pts whose Hp was eradicated (%) . | Mean (SD) or median (range) follow-up time after treatment, mos . | Comments . |
|---|---|---|---|---|---|---|---|---|---|---|
| Gasbarrini | Italian 45 (±14) | 18 (NA) | 11 (61.1) | Breath test | 95 (±39) | 11 (0) | 8 (72.7) | 8/8 (100) | 4 (NA) | None of the patients had marked thrombocytopenia before eradication |
| Emilia | Italian 50 (17-89) | 30 (30) | 13 (43.3) | Breath test, histol | 53 (±23.5) | 13 (3) | 12 (92.3) | 6/12 (50) | 8.3 (6-12) | Hp was more frequent in men. In an updated follow-up4 (median of 31.1 mos), 1 patient relapsed. |
| Veneri | Italian (NA) | 35 (NA) | 25 (71.4) | Breath test, histol | 51 (±28) | 16 (4) | 15 (93.6) | 11/15 (73.3) | 11.7 (6-28) | Two patients with severe chronic ITP responded. |
| Kohda | Japanese 52.7 (24-80) | 48 (40) | 25 (62.5) | Breath test, histol, serum Abs | 67 (±54) | 19 (NA) | 19 (100.0) | 12/19 (63) | 14.8 (9-39) | No change in plt count in Hp+ untreated patients. Six of 8 patients with refractory ITP responded. |
| Hashino | Japanese (NA) | 22 (22) | 14 (63.6) | Histol + culture | (NA) | 14 (NA) | 13 (82.9) | 5/13 (38.4) | 15 (NA) | One patient who had an initial complete response relapsed without Hp reinfection. |
| Hino | Japanese 54 (26-84) | 30 (25) | 21 (70.0) | Breath test, serum Abs | 32 (±19.75) | 21 (7) | 18 (85.7) | 10/18 (55.6) | NA | Three Hp- patients were treated without plt count increase. |
| Michel | French 40 (±19.8) | 51 (42) | 15 (29.4) | Serum Abs | 13 (1-50) | None treated | — | — | — | Hp prevalence was similar in controls. No differences were found between Hp+ and Hp- patients. The effect of eradication was not tested. |
| Jarque | Spanish (NA) | 56 (56) | 40 (71.4) | Breath test | 57 (±22) | 32 (NA) | 23 (71.9) | 3/23 (13) | Response assessed after 3 mos | Response rates were similar in Hp+ and Hp- patients. |
| This report | White, Hispanics 41 (± 18.3) | 74 (67) | 16 (21.6) | Breath test | 34 (10-54) | 15 (7) | 14 (93.3) | 1/14 (7) | 11.5 (3-18) | Eradication therapy also ineffective in 10 Hp- patients. |
| Total | — | 364 | 180 (49.5) | — | — | 141 | 122 (86.5) | 56/122 (46) | — | — |
Pts indicates patients; SD, standard deviation; Hp, H pylori; plt, platelet; PR/CR, partial or complete response according to the author criteria; mos, months; NA, data not available; histol, H pylori infection confirmed by histology; Abs, specific anti-H pylori antibodies (IgG); and—, not applicable.