Risk factors for death in patients who developed hyperbilirubinemia greater than 68.4 μM (4 mg/dL)
Variable . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| Univariate analysis | |||
| Time to total serum bilirubin level, 68.4 μM (4 mg/dL) or greater, per month | 1.5 | 1.2-1.8 | < .0001 |
| Disease | |||
| Aggressive | 2.8 | 1.3-6.3 | .006 |
| Indolent | 1.0 | ||
| Hemolysis as primary etiology of jaundice | |||
| Yes | 0.2 | 0.0-1.4 | .03 |
| No | 1.0 | ||
| Sex | |||
| Male | 0.9 | 0.5-1.8 | .84 |
| Female | 1.0 | ||
| Donor | |||
| Unrelated | 0.8 | 0.4-1.7 | .49 |
| Related | 1.0 | ||
| Fludarabine in conditioning | |||
| Yes | 0.6 | 0.3-1.2 | .17 |
| No | 1.0 | ||
| Multivariate analysis | |||
| Time to total serum bilirubin level, 68.4 μM (4 mg/dL) or greater, per month | 1.5 | 1.2-1.8 | < .0001 |
| Disease | |||
| Aggressive | 3.0 | 1.3-6.8 | .005 |
| Indolent | 1.0 |
Variable . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| Univariate analysis | |||
| Time to total serum bilirubin level, 68.4 μM (4 mg/dL) or greater, per month | 1.5 | 1.2-1.8 | < .0001 |
| Disease | |||
| Aggressive | 2.8 | 1.3-6.3 | .006 |
| Indolent | 1.0 | ||
| Hemolysis as primary etiology of jaundice | |||
| Yes | 0.2 | 0.0-1.4 | .03 |
| No | 1.0 | ||
| Sex | |||
| Male | 0.9 | 0.5-1.8 | .84 |
| Female | 1.0 | ||
| Donor | |||
| Unrelated | 0.8 | 0.4-1.7 | .49 |
| Related | 1.0 | ||
| Fludarabine in conditioning | |||
| Yes | 0.6 | 0.3-1.2 | .17 |
| No | 1.0 | ||
| Multivariate analysis | |||
| Time to total serum bilirubin level, 68.4 μM (4 mg/dL) or greater, per month | 1.5 | 1.2-1.8 | < .0001 |
| Disease | |||
| Aggressive | 3.0 | 1.3-6.8 | .005 |
| Indolent | 1.0 |