Table 2.

Frequency and etiology of hyperbilirubinemia to day +200 after transplantation


Maximum total serum bilirubin level, mg/dL

No. (%)

Day maximum bilirubin level, median (range)

Primary cause of jaundice

No.
Less than 1.2   30 (16)   NA   NA   NA  
1.3-3.9   112 (58)   11 (0-199)   NE   —  
4.0-6.9   25 (13)   18 (3-164)   Cholestasis due to GVHD or cholangitis lenta   14  
    CSP-related cholestasis   5  
    Hemolysis   3  
    Metastatic solid tumor   2  
    Ischemia   1  
7.0-9.9   7 (3)   27 (4-196)   CSP-related cholestasis   3  
    Cholestasis due to GVHD or cholangitis lenta   2  
    Hemolysis   1  
    Ischemia   1  
Greater than 10.0   19 (10)   70 (5-188)   Cholestasis due to GVHD or cholangitis lenta   11  
    Decompensated chronic liver disease   3  
    CSP-related cholestasis   2  
    Hemolysis   1  
    Ischemia (Aspergillus embolization)   1  

 

 

 
Labetalol hepatitis
 
1
 

Maximum total serum bilirubin level, mg/dL

No. (%)

Day maximum bilirubin level, median (range)

Primary cause of jaundice

No.
Less than 1.2   30 (16)   NA   NA   NA  
1.3-3.9   112 (58)   11 (0-199)   NE   —  
4.0-6.9   25 (13)   18 (3-164)   Cholestasis due to GVHD or cholangitis lenta   14  
    CSP-related cholestasis   5  
    Hemolysis   3  
    Metastatic solid tumor   2  
    Ischemia   1  
7.0-9.9   7 (3)   27 (4-196)   CSP-related cholestasis   3  
    Cholestasis due to GVHD or cholangitis lenta   2  
    Hemolysis   1  
    Ischemia   1  
Greater than 10.0   19 (10)   70 (5-188)   Cholestasis due to GVHD or cholangitis lenta   11  
    Decompensated chronic liver disease   3  
    CSP-related cholestasis   2  
    Hemolysis   1  
    Ischemia (Aspergillus embolization)   1  

 

 

 
Labetalol hepatitis
 
1
 

1 mg/dL bilirubin equals 17.1 μM.

NA indicates not applicable; NE, not evaluated.

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