Biodistribution of 125I-L 19scFv, 125I-L 19mTNFα, and 125I-TN11mTNFα in F9 tumor-bearing mice at different time points
. | 3 h . | 6 h . | 24 h . | 48 h . |
|---|---|---|---|---|
| 125I-L 19-(scFv)2* | ||||
| Tumor | 10.46 (1.75) | 8.15 (2.63) | 3.18 (0.83) | 2.83 (0.71) |
| Blood | 2.05 (0.38) | 1.88 (1.14) | 0.17 (0.01) | 0.06 (0.02) |
| Liver | 1.62 (1.67) | 0.73 (0.51) | 0.07 (0.01) | 0.04 (0.02) |
| Spleen | 1.53 (0.36) | 0.90 (0.54) | 0.11 (0.01) | 0.05 (0.01) |
| Kidney | 12.70 (0.73) | 4.37 (0.98) | 0.24 (0.03) | 0.18 (0.08) |
| Intestine | 0.68 (0.15) | 0.95 (0.23) | 0.24 (0.01) | 0.17 (0.06) |
| Heart | 1.35 (0.21) | 0.81 (0.38) | 0.08 (0.02) | 0.04 (0.01) |
| Lung | 2.88 (0.29) | 2.06 (0.69) | 0.38 (0.60) | 0.33 (0.05) |
| 125I-L 19mTNFα | ||||
| Tumor | 22.03 (2.32) | 11.57 (2.69) | 9.77 (1.37) | 9.55 (3.21) |
| Blood | 8.39 (5.01) | 2.13 (0.96) | 0.09 (0.02) | 0.01 (0.05) |
| Liver | 8.43 (1.94) | 2.39 (0.93) | 0.08 (0.01) | 0.02 (0.02) |
| Spleen | 9.08 (1.98) | 3.29 (0.94) | 0.13 (0.01) | 0.01 (0.03) |
| Kidney | 7.96 (2.96) | 6.05 (5.16) | 0.18 (0.01) | 0.04 (0.04) |
| Intestine | 2.51 (0.78) | 1.61 (0.62) | 0.13 (0.00) | 0.01 (0.04) |
| Heart | 2.69 (0.76) | 1.32 (0.49) | 0.06 (0.02) | 0.00 (0.02) |
| Lung | 6.56 (1.73) | 2.79 (1.49) | 0.18 (0.07) | 0.02 (0.05) |
| 125I-TN11mTNFα | ||||
| Tumor | ND | 2.51 (0.41) | 0.48 (0.15) | 0.28 (0.03) |
| Blood | ND | 2.88 (0.48) | 0.17 (0.03) | 0.04 (0.01) |
| Liver | ND | 2.78 (0.22) | 0.69 (0.02) | 0.36 (0.03) |
| Spleen | ND | 3.20 (0.31) | 0.49 (0.19) | 0.30 (0.02) |
| Kidney | ND | 2.67 (0.88) | 0.22 (0.04) | 0.07 (0.01) |
| Intestine | ND | 1.01 (0.13) | 0.13 (0.03) | 0.03 (0.01) |
| Heart | ND | 0.99 (0.15) | 0.09 (0.01) | 0.04 (0.01) |
| Lung | ND | 6.68 (1.44) | 0.27 (0.09) | 0.19 (0.19) |
. | 3 h . | 6 h . | 24 h . | 48 h . |
|---|---|---|---|---|
| 125I-L 19-(scFv)2* | ||||
| Tumor | 10.46 (1.75) | 8.15 (2.63) | 3.18 (0.83) | 2.83 (0.71) |
| Blood | 2.05 (0.38) | 1.88 (1.14) | 0.17 (0.01) | 0.06 (0.02) |
| Liver | 1.62 (1.67) | 0.73 (0.51) | 0.07 (0.01) | 0.04 (0.02) |
| Spleen | 1.53 (0.36) | 0.90 (0.54) | 0.11 (0.01) | 0.05 (0.01) |
| Kidney | 12.70 (0.73) | 4.37 (0.98) | 0.24 (0.03) | 0.18 (0.08) |
| Intestine | 0.68 (0.15) | 0.95 (0.23) | 0.24 (0.01) | 0.17 (0.06) |
| Heart | 1.35 (0.21) | 0.81 (0.38) | 0.08 (0.02) | 0.04 (0.01) |
| Lung | 2.88 (0.29) | 2.06 (0.69) | 0.38 (0.60) | 0.33 (0.05) |
| 125I-L 19mTNFα | ||||
| Tumor | 22.03 (2.32) | 11.57 (2.69) | 9.77 (1.37) | 9.55 (3.21) |
| Blood | 8.39 (5.01) | 2.13 (0.96) | 0.09 (0.02) | 0.01 (0.05) |
| Liver | 8.43 (1.94) | 2.39 (0.93) | 0.08 (0.01) | 0.02 (0.02) |
| Spleen | 9.08 (1.98) | 3.29 (0.94) | 0.13 (0.01) | 0.01 (0.03) |
| Kidney | 7.96 (2.96) | 6.05 (5.16) | 0.18 (0.01) | 0.04 (0.04) |
| Intestine | 2.51 (0.78) | 1.61 (0.62) | 0.13 (0.00) | 0.01 (0.04) |
| Heart | 2.69 (0.76) | 1.32 (0.49) | 0.06 (0.02) | 0.00 (0.02) |
| Lung | 6.56 (1.73) | 2.79 (1.49) | 0.18 (0.07) | 0.02 (0.05) |
| 125I-TN11mTNFα | ||||
| Tumor | ND | 2.51 (0.41) | 0.48 (0.15) | 0.28 (0.03) |
| Blood | ND | 2.88 (0.48) | 0.17 (0.03) | 0.04 (0.01) |
| Liver | ND | 2.78 (0.22) | 0.69 (0.02) | 0.36 (0.03) |
| Spleen | ND | 3.20 (0.31) | 0.49 (0.19) | 0.30 (0.02) |
| Kidney | ND | 2.67 (0.88) | 0.22 (0.04) | 0.07 (0.01) |
| Intestine | ND | 1.01 (0.13) | 0.13 (0.03) | 0.03 (0.01) |
| Heart | ND | 0.99 (0.15) | 0.09 (0.01) | 0.04 (0.01) |
| Lung | ND | 6.68 (1.44) | 0.27 (0.09) | 0.19 (0.19) |
The results are given as the average of 3 %ID/g (SD). ND indicates not done.
Dimeric form of L19 scFv.