Diagnostic criteria for CDA II: presence of all A-criteria and of at least one B criterion is required
A criteria |
| A1: Evidence of congenital anemia/jaundice or heredity |
| A2: Evidence of ineffective erythropoiesis |
| A3: Typical morphologic appearance of bone marrow erythroblasts, with at least 10% binucleated red cell precursors |
| B criteria |
| B1: Positive acid lysis with at least 20% of normal sera |
| B2: Typical abnormality of bands 3 and 4.5 in SDS-PAGE |
| B3: Double membrane running internally from the cell membrane of late erythroblasts seen by electron microscopy (EM) |
A criteria |
| A1: Evidence of congenital anemia/jaundice or heredity |
| A2: Evidence of ineffective erythropoiesis |
| A3: Typical morphologic appearance of bone marrow erythroblasts, with at least 10% binucleated red cell precursors |
| B criteria |
| B1: Positive acid lysis with at least 20% of normal sera |
| B2: Typical abnormality of bands 3 and 4.5 in SDS-PAGE |
| B3: Double membrane running internally from the cell membrane of late erythroblasts seen by electron microscopy (EM) |