SOCS1-deficient CD8+ thymocytes developing in FTOCs show elevated CD44 expression
. | SOCS1+/+ . | . | SOCS1−/− . | . | ||
|---|---|---|---|---|---|---|
| FTOC . | Total, × 104 . | % CD8+44hi . | Total, × 104 . | % CD8+44hi . | ||
| Day 6 | 7.8 ± 0.5 | 15 ± 7 | 7.0 ± 0.6 | 24 ± 3 | ||
| Day 8 | 5.9 ± 0.8 | 24 ± 5 | 5.1 ± 0.5 | 44 ± 8 | ||
| Day 10 | 5.0 ± 1.0 | 34 ± 11 | 5.2 ± 1.0 | 46 ± 11 | ||
| Day 12 | 6.2 ± 0.6 | 34 ± 3 | 5.2 ± 0.6 | 57 ± 4 | ||
. | SOCS1+/+ . | . | SOCS1−/− . | . | ||
|---|---|---|---|---|---|---|
| FTOC . | Total, × 104 . | % CD8+44hi . | Total, × 104 . | % CD8+44hi . | ||
| Day 6 | 7.8 ± 0.5 | 15 ± 7 | 7.0 ± 0.6 | 24 ± 3 | ||
| Day 8 | 5.9 ± 0.8 | 24 ± 5 | 5.1 ± 0.5 | 44 ± 8 | ||
| Day 10 | 5.0 ± 1.0 | 34 ± 11 | 5.2 ± 1.0 | 46 ± 11 | ||
| Day 12 | 6.2 ± 0.6 | 34 ± 3 | 5.2 ± 0.6 | 57 ± 4 | ||
Thymocytes from FTOCs shown in Figure 2A were stained for CD4, CD8, and CD44, and the frequency of CD8+ cells showing high levels of CD44 expression was estimated. Total cell numbers represent the mean ± SD of at least 3 thymi per group for each time point.