Patterns of somatic mutations in the rearranged immunoglobulin genes of B-cell populations
. | Average immunoglobulin mutation incidence, % . | Ongoing mutations . | Reference no. . |
|---|---|---|---|
| Mantle zone cells | 0 | No | 37 |
| Germinal center cells | 7.9 | Yes | 37 |
| Memory cells | 2, 27, 32, 38-40 | ||
| CD27+IgM+IgD+ | 5 | No | |
| IgM+ only | 1.5-6 | No | |
| IgG+ | 4-12.6 | No | |
| Marginal zone cells | 5 | ||
| Splenic | 4.2 | Possible | |
| Nodal | 2.6 | Possible | |
| Monocytoid B cells | 0-3.8* | No | 4, 5, 41 |
| Plasma cells | 8.5-9.0 | No | 42 |
| Interfollicular large B cells | 9 | NA† | This study |
. | Average immunoglobulin mutation incidence, % . | Ongoing mutations . | Reference no. . |
|---|---|---|---|
| Mantle zone cells | 0 | No | 37 |
| Germinal center cells | 7.9 | Yes | 37 |
| Memory cells | 2, 27, 32, 38-40 | ||
| CD27+IgM+IgD+ | 5 | No | |
| IgM+ only | 1.5-6 | No | |
| IgG+ | 4-12.6 | No | |
| Marginal zone cells | 5 | ||
| Splenic | 4.2 | Possible | |
| Nodal | 2.6 | Possible | |
| Monocytoid B cells | 0-3.8* | No | 4, 5, 41 |
| Plasma cells | 8.5-9.0 | No | 42 |
| Interfollicular large B cells | 9 | NA† | This study |
Data on known B-cell populations are from previously published studies. NA indicates not available.
According to Stein et al,4 only a fraction of monocytoid B cells (26%) carry mutated IgH rearrangements, whereas the majority (74%) are unmutated. Other studies have identified only mutated immunoglobulin genes.5,41
It was impossible to establish whether the cells show ongoing mutations, because the derived IgH rearrangements were not clonally related in any case examined.