Down-regulated genes in day-6 Hex−/− embryoid bodies
P . | Fold change . | Gene . |
|---|---|---|
| .002653 | −3.78 | X04480: Insulin-like growth factor 1 |
| .010953 | −3.75 | X02677: Solute carrier family 4 (anion exchanger) |
| .000017 | −3.56 | X58196: H19 fetal liver |
| .001568 | −2.78 | AF081789: Cell surface antigen AA4 |
| .031296 | −2.57 | U82758: Claudin 5 |
| .000067 | −2.52 | Y17851: Ganglioside-induced differentiation-associated protein 2 |
| .001432 | −2.40 | AF057527: Erythrocyte membrane protein Rh50 (Rhag) |
| .001569 | −2.37 | AW060556: Stabilin 1 (Stab1) |
| .004042 | −2.34 | D49544: Kinesin family member C1 (Kifc1) |
| .003058 | −2.29 | AI853217: VE-cadherin |
| .001761 | −2.28 | J04696: Mouse glutathione S-transferase class mu (GST5-5) |
| .000048 | −2.23 | L17076: HnRNP-associated with lethal yellow RNA-binding protein mRNA |
| .000672 | −2.18 | V00722: Beta-1-globin |
| .004949 | −2.12 | AW046391: Hypothetical protein |
| .000210 | −2.10 | J00413: Hemoglobin, beta adult major chain |
| .002405 | −2.02 | AF087644: Coagulation factor X |
| .032201 | −2.01 | U04055: Erythrocyte protein band 4.2 |
| .018315 | −1.98 | AV303514: Phosphatidylinositol-4-phosphate 5-kinase, type II |
| .000977 | −1.98 | D16215: Flavin-containing monooxygenase |
| .008922 | −1.96 | AW048779: hypothetical gene supported by BC027302 |
| .003111 | −1.94 | X15591: Cytotoxic T lymphocyte-associated protein 2 alpha |
| .017759 | −1.89 | AV266785: Complement component 1 subunit r |
| .010371 | −1.88 | M26385: Glycophorin A |
| .000978 | −1.88 | AJ250490: Receptor activity modifying protein 2 (Ramp2 gene) |
| .015505 | −1.85 | AA690483: Unknown Mus musculus adult male liver tumor cDNA |
| .025388 | −1.83 | AA673486: Unknown Mus musculus 4 days neonate thymus and hematopoietic stem cell cDNA |
| .011468 | −1.81 | AW049647: ADP ribosylation factor 6 interacting protein 5 |
| .000226 | −1.78 | U19604: DNA ligase I, ATP dependent |
| .009390 | −1.78 | AI845915: POL 1 and transcript release factor |
| .023288 | −1.77 | M15501: Actin, alpha, cardiac |
| .018349 | −1.75 | AV235418: Tyrosine kinase receptor 1 (Tie 1) |
| .011321 | −1.74 | X14061: Hemoglobin beta, pseudogene bh3 |
| .008537 | −1.73 | AF017275: Growth factor-independent 1B |
| .017719 | −1.73 | AF110520: NADH oxidoreductase |
| .017687 | −1.71 | X15763: GATA-1 |
| .003072 | −1.70 | U95736: Frataxin |
| .015075 | −1.70 | AF004833: Tissue factor pathway inhibitor (TFPI) |
| .000928 | −1.69 | M27938: Male enhanced antigen 1 |
| .026540 | −1.68 | M97200: Erythroid Kruppel-like factor (EKLF) |
| .013354 | −1.66 | AA285978: ADP-ribosylation-like factor 6 interacting protein 5 (Arl6ip5) |
| .006031 | −1.66 | AF084524: EIA-stimulated genes CREG |
| .013729 | −1.64 | AF647239: Unknown adult male kidney cDNA |
| .009494 | −1.62 | AA726364: Lipoprotein lipase (Lpl) |
| .034037 | −1.61 | AW124226: Unknown adult male hippocampus cDNA |
| .004018 | −1.60 | AF087434: NF-ATc isoform a (NF-ATc) |
| .021581 | −1.60 | U20619: Serine-rich RNA polymerase suppressor protein 1 (SRP1) |
| .020747 | −1.60 | AW124340: Unknown Mus musculus 2 days neonate thymic cells cDNA, similar to zinc transporter |
| .012994 | −1.59 | AI840130: Src activating and signaling molecule (Srcasm) |
| .019533 | −1.59 | M35153: Lamin B1 |
| .006731 | −1.56 | AW125390: Unknown Mus musculus 18-day embryo whole body cDNA |
| .012535 | −1.56 | AB011665: BAZF, complete cds/cds = (24,1448) |
| .001342 | −1.56 | AI844357: Immature colon carcinoma transcript 1 |
| .017822 | −1.55 | V00714: Hemoglobin alpha, adult chain 1 |
| .043322 | −1.55 | AA755260: Deleted in polyposis 1-like 1 |
| .029021 | −1.55 | AA726223: Meltrin beta metalloproteinase |
| .009957 | −1.55 | AI849082: Goliath-related zinc finger protein |
| .013799 | −1.55 | AI197161: ELL-related RNA polymerase II, elongation factor |
| .002423 | −1.54 | AF000294: Peroxisome proliferator-activated receptor gamma binding protein (PPARgamma) |
| .013278 | −1.54 | U34691: Uroporphyrinogen decarboxylase |
| .009814 | −1.53 | AJ010045: Rho guanine nucleotide-exchange factor |
| .006577 | −1.51 | AI836162: SRY-box containing gene 18 (Sox18) |
| .028268 | −1.51 | AI155192: BIRC 5 (Baculovirus IAP-repeat containing 5) |
| .005933 | −1.50 | L35528: Manganese superoxide dismutase (MnSOD) gene |
| .021623 | −1.50 | AI841295: Glutathione S-transferase subunit 13 |
| .003194 | −1.50 | X77952: Endoglin |
| .007243 | −1.50 | L07508: Golli-mpb |
| .003337 | −1.49 | AW050240: Casein kinase II, alpha I-related sequence 4 |
| .007000 | −1.49 | AB007136: Protease (prosome, macropain) 28 subunit, alpha |
| .011080 | −1.48 | Y17343: Protein-tyrosine-phosphatase IF2P |
| .002985 | −1.48 | AW122685: Similar to TMP21 vesicular transport protein |
| .000312 | −1.47 | AF069051: Pituitary tumor transforming gene protein (PTTG) |
| .014099 | −1.47 | AF004326: Angiopoietin 2 |
| .003649 | −1.47 | AI842600: Pre-T cell RS21-C6 (Tdrg-TL1) protein |
| .000485 | −1.47 | AI836509: Unknown 12 days embryo male wolffian duct |
| .012981 | −1.47 | D85818: RNA polymerase II subuunit RPB14 |
| .004562 | −1.47 | AI848107: Unknown Mus musculus 18-day embryo whole body cDNA |
| .023514 | −1.46 | J04181: A-X actin mRNA |
P . | Fold change . | Gene . |
|---|---|---|
| .002653 | −3.78 | X04480: Insulin-like growth factor 1 |
| .010953 | −3.75 | X02677: Solute carrier family 4 (anion exchanger) |
| .000017 | −3.56 | X58196: H19 fetal liver |
| .001568 | −2.78 | AF081789: Cell surface antigen AA4 |
| .031296 | −2.57 | U82758: Claudin 5 |
| .000067 | −2.52 | Y17851: Ganglioside-induced differentiation-associated protein 2 |
| .001432 | −2.40 | AF057527: Erythrocyte membrane protein Rh50 (Rhag) |
| .001569 | −2.37 | AW060556: Stabilin 1 (Stab1) |
| .004042 | −2.34 | D49544: Kinesin family member C1 (Kifc1) |
| .003058 | −2.29 | AI853217: VE-cadherin |
| .001761 | −2.28 | J04696: Mouse glutathione S-transferase class mu (GST5-5) |
| .000048 | −2.23 | L17076: HnRNP-associated with lethal yellow RNA-binding protein mRNA |
| .000672 | −2.18 | V00722: Beta-1-globin |
| .004949 | −2.12 | AW046391: Hypothetical protein |
| .000210 | −2.10 | J00413: Hemoglobin, beta adult major chain |
| .002405 | −2.02 | AF087644: Coagulation factor X |
| .032201 | −2.01 | U04055: Erythrocyte protein band 4.2 |
| .018315 | −1.98 | AV303514: Phosphatidylinositol-4-phosphate 5-kinase, type II |
| .000977 | −1.98 | D16215: Flavin-containing monooxygenase |
| .008922 | −1.96 | AW048779: hypothetical gene supported by BC027302 |
| .003111 | −1.94 | X15591: Cytotoxic T lymphocyte-associated protein 2 alpha |
| .017759 | −1.89 | AV266785: Complement component 1 subunit r |
| .010371 | −1.88 | M26385: Glycophorin A |
| .000978 | −1.88 | AJ250490: Receptor activity modifying protein 2 (Ramp2 gene) |
| .015505 | −1.85 | AA690483: Unknown Mus musculus adult male liver tumor cDNA |
| .025388 | −1.83 | AA673486: Unknown Mus musculus 4 days neonate thymus and hematopoietic stem cell cDNA |
| .011468 | −1.81 | AW049647: ADP ribosylation factor 6 interacting protein 5 |
| .000226 | −1.78 | U19604: DNA ligase I, ATP dependent |
| .009390 | −1.78 | AI845915: POL 1 and transcript release factor |
| .023288 | −1.77 | M15501: Actin, alpha, cardiac |
| .018349 | −1.75 | AV235418: Tyrosine kinase receptor 1 (Tie 1) |
| .011321 | −1.74 | X14061: Hemoglobin beta, pseudogene bh3 |
| .008537 | −1.73 | AF017275: Growth factor-independent 1B |
| .017719 | −1.73 | AF110520: NADH oxidoreductase |
| .017687 | −1.71 | X15763: GATA-1 |
| .003072 | −1.70 | U95736: Frataxin |
| .015075 | −1.70 | AF004833: Tissue factor pathway inhibitor (TFPI) |
| .000928 | −1.69 | M27938: Male enhanced antigen 1 |
| .026540 | −1.68 | M97200: Erythroid Kruppel-like factor (EKLF) |
| .013354 | −1.66 | AA285978: ADP-ribosylation-like factor 6 interacting protein 5 (Arl6ip5) |
| .006031 | −1.66 | AF084524: EIA-stimulated genes CREG |
| .013729 | −1.64 | AF647239: Unknown adult male kidney cDNA |
| .009494 | −1.62 | AA726364: Lipoprotein lipase (Lpl) |
| .034037 | −1.61 | AW124226: Unknown adult male hippocampus cDNA |
| .004018 | −1.60 | AF087434: NF-ATc isoform a (NF-ATc) |
| .021581 | −1.60 | U20619: Serine-rich RNA polymerase suppressor protein 1 (SRP1) |
| .020747 | −1.60 | AW124340: Unknown Mus musculus 2 days neonate thymic cells cDNA, similar to zinc transporter |
| .012994 | −1.59 | AI840130: Src activating and signaling molecule (Srcasm) |
| .019533 | −1.59 | M35153: Lamin B1 |
| .006731 | −1.56 | AW125390: Unknown Mus musculus 18-day embryo whole body cDNA |
| .012535 | −1.56 | AB011665: BAZF, complete cds/cds = (24,1448) |
| .001342 | −1.56 | AI844357: Immature colon carcinoma transcript 1 |
| .017822 | −1.55 | V00714: Hemoglobin alpha, adult chain 1 |
| .043322 | −1.55 | AA755260: Deleted in polyposis 1-like 1 |
| .029021 | −1.55 | AA726223: Meltrin beta metalloproteinase |
| .009957 | −1.55 | AI849082: Goliath-related zinc finger protein |
| .013799 | −1.55 | AI197161: ELL-related RNA polymerase II, elongation factor |
| .002423 | −1.54 | AF000294: Peroxisome proliferator-activated receptor gamma binding protein (PPARgamma) |
| .013278 | −1.54 | U34691: Uroporphyrinogen decarboxylase |
| .009814 | −1.53 | AJ010045: Rho guanine nucleotide-exchange factor |
| .006577 | −1.51 | AI836162: SRY-box containing gene 18 (Sox18) |
| .028268 | −1.51 | AI155192: BIRC 5 (Baculovirus IAP-repeat containing 5) |
| .005933 | −1.50 | L35528: Manganese superoxide dismutase (MnSOD) gene |
| .021623 | −1.50 | AI841295: Glutathione S-transferase subunit 13 |
| .003194 | −1.50 | X77952: Endoglin |
| .007243 | −1.50 | L07508: Golli-mpb |
| .003337 | −1.49 | AW050240: Casein kinase II, alpha I-related sequence 4 |
| .007000 | −1.49 | AB007136: Protease (prosome, macropain) 28 subunit, alpha |
| .011080 | −1.48 | Y17343: Protein-tyrosine-phosphatase IF2P |
| .002985 | −1.48 | AW122685: Similar to TMP21 vesicular transport protein |
| .000312 | −1.47 | AF069051: Pituitary tumor transforming gene protein (PTTG) |
| .014099 | −1.47 | AF004326: Angiopoietin 2 |
| .003649 | −1.47 | AI842600: Pre-T cell RS21-C6 (Tdrg-TL1) protein |
| .000485 | −1.47 | AI836509: Unknown 12 days embryo male wolffian duct |
| .012981 | −1.47 | D85818: RNA polymerase II subuunit RPB14 |
| .004562 | −1.47 | AI848107: Unknown Mus musculus 18-day embryo whole body cDNA |
| .023514 | −1.46 | J04181: A-X actin mRNA |
Microarray analysis of gene expression patterns in Hex+/+ versus Hex−/− EBs. Note that a number of hematopoietic- and endothelial-specific genes exhibit decreased expression. These data represent averages and statistical analysis from 4 distinct Hex+/+ and 4 distinct Hex−/− day-6 EB experiments performed using individual gene chips, for each experiment (total 8 chips).