Molecular characteristics of monoclonal B cell PTLD carrying nonfunctional IgVH gene rearrangements
. | . | IgVH . | . | . | . | . | . | IgVL . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case . | Histology . | IgVH family . | Closest IgVH germ-line gene . | % of mutations . | D . | JH . | Functional status . | IgVL family . | Closest IgVL germline gene . | % of mutation . | JL . | Functional status . | |||||||||
| 3521 | P-PTLD | VH3 | 3-30 | GL | D3-9 | JH4b | Out of frame | Vk2 | A18 | GL | NA | Pseudogene | |||||||||
| 3527 | DLBCL, centroblastic | VH4 | 4-30.1 | 7.12 | NA | JH3b | Out of frame | — | — | — | — | — | |||||||||
| 2892 | DLBCL, immunoblastic | VH3 | 3-66 | 8.59 | NA | JH6b | Out of frame | Vk3 | L2 | 5.42 | Jk1 | Crippled | |||||||||
| 2895 | DLBCL, immunoblastic | VH3 | 3-07 | 7.20 | NA | JH6b | Crippled | Vk1 | L12 | 6.32 | Jk1 | Crippled | |||||||||
| 2915 | DLBCL, immunoblastic | VH3 | 3-30.3 | 11.8 | D1-26 | JH6b | Crippled | Vλ 1 | 1e | 7.67 | Jλ2 | Crippled | |||||||||
| 3461 | DLBCL, immunoblastic | VH4 | 4-34 | 7.42 | D4-17 | JH6b | Crippled | Vk1 | L12 | 6.9 | Jk1 | Crippled | |||||||||
| 3520 | DLBCL, immunoblastic | VH4 | 4-30.2 | 10.7 | D3-10 | JH5b | Out of frame | Vk4 | B3 | GL | Jk3 | Functional | |||||||||
| 3526 | BL/BLL | VH1 | hv1263 | GL | NA | JH6c | Out of frame | Vλ2 | 2c | 4.95 | Jλ2 | Crippled | |||||||||
. | . | IgVH . | . | . | . | . | . | IgVL . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case . | Histology . | IgVH family . | Closest IgVH germ-line gene . | % of mutations . | D . | JH . | Functional status . | IgVL family . | Closest IgVL germline gene . | % of mutation . | JL . | Functional status . | |||||||||
| 3521 | P-PTLD | VH3 | 3-30 | GL | D3-9 | JH4b | Out of frame | Vk2 | A18 | GL | NA | Pseudogene | |||||||||
| 3527 | DLBCL, centroblastic | VH4 | 4-30.1 | 7.12 | NA | JH3b | Out of frame | — | — | — | — | — | |||||||||
| 2892 | DLBCL, immunoblastic | VH3 | 3-66 | 8.59 | NA | JH6b | Out of frame | Vk3 | L2 | 5.42 | Jk1 | Crippled | |||||||||
| 2895 | DLBCL, immunoblastic | VH3 | 3-07 | 7.20 | NA | JH6b | Crippled | Vk1 | L12 | 6.32 | Jk1 | Crippled | |||||||||
| 2915 | DLBCL, immunoblastic | VH3 | 3-30.3 | 11.8 | D1-26 | JH6b | Crippled | Vλ 1 | 1e | 7.67 | Jλ2 | Crippled | |||||||||
| 3461 | DLBCL, immunoblastic | VH4 | 4-34 | 7.42 | D4-17 | JH6b | Crippled | Vk1 | L12 | 6.9 | Jk1 | Crippled | |||||||||
| 3520 | DLBCL, immunoblastic | VH4 | 4-30.2 | 10.7 | D3-10 | JH5b | Out of frame | Vk4 | B3 | GL | Jk3 | Functional | |||||||||
| 3526 | BL/BLL | VH1 | hv1263 | GL | NA | JH6c | Out of frame | Vλ2 | 2c | 4.95 | Jλ2 | Crippled | |||||||||
All PTLDs included in this table failed to express Ig molecules.
P-PTLD indicates polymorphic PTLD; GL, germ line; DLBCL, diffuse large B-cell lymphoma; NA, not able to be aligned; —, no product found; and BL/BLL, Burkitt lymphoma/Burkitt-like lymphoma.