Table 1.

Clinical and virologic features of monoclonal B-cell PTLDs

Case
Histology
Sex
TX
Age at TX, y
Immune suppression
Interval from TX, mo
Tumor site
Stage
EBV
Treatment modalities*
Response
Outcome, mo from PTLD
2614   P-PTLD   M   Lung   46   C + A   5   Lung   IIE  +   CT   SD   Death at 1 mo  
2618   P-PTLD   M   Heart   67   C + A   6   Lung   IIE  +   No treatment   CR   Alive at 76 mo  
2913A   P-PTLD   M   Heart   38   C + A   152   Tonsil   IE  -   CT + RT   CR   Death at 16 mo  
2916   P-PTLD   M   Heart   54   C + A   6   Lung   IE  +   S   CR   Alive at 54 mo  
3462   P-PTLD   M   Liver   61   C + A   7   Liver   IE  +   NA   NA   Autoptic diagnosis  
3464   P-PTLD   M   Liver   59   C + A   5   Liver   IE  +   S + anti-CD20 + HDIg   CR   Alive at 27 mo  
3468   P-PTLD   M   Heart   53   C + A   2   Tongue   IE  +   No treatment   CR   Alive at 23 mo  
3471   P-PTLD   M   Liver   33   C + A   7   Liver   IV   +   CT + HDIg + RF   CR   Alive at 31 mo  
3515   P-PTLD   M   Heart   13   C + A   79   Lymph node   II   -   CT   PD   Death at 18 mo  
3516   P-PTLD   M   Heart   18   C + A   22   Lymph node   II   +   CT   NE   Death at 20 mo  
3519   P-PTLD   M   Heart   59   C + A   84   Lymph node   III   -   CT   NE   Death at 6 mo  
3521   P-PTLD   F   Heart   14   C + A   51   Lymph node   I   +   S   CR   Alive at 41 mo  
2798   DLBCL, CB   F   Kidney   58   C + A   103   Lymph node   II   -   CT + HDIg   CR   Alive at 45 mo  
2898   DLBCL, CB   M   Heart   34   C + A   81   Lymph node   III   -   CT + S + HDIg   CR   Alive at 52 mo  
2909   DLBCL, CB   M   Heart   59   C + A   44   Spleen   III   -   No treatment   PD   Death at 5 mo  
2912   DLBCL, CB   M   Heart   43   C + A   113   Mesenteric mass   II   -   CT   PR   Death at 15 mo  
2914   DLBCL, CB   M   Heart   48   C + A   110   Stomach   IV   -   CT   CR   Alive at 70 mo  
3459   DLBCL, CB   M   Lung   27   C + A   128   Lymph node   IV   +   CT + anti-CD20 + HDIg   CR   Alive at 25 mo  
3465   DLBCL, CB   F   Liver   55   C + A   95   Lymph node   III   -   CT   CR   Alive at 21 mo  
3466   DLBCL, CB   M   Liver   45   C + A   104   Skin   IE  -   CT + S   CR   Alive at 22 mo  
3467   DLBCL, CB   M   Heart   52   C + A   128   Lymph node   IV   +   P   NA   Death at 1 d  
3518   DLBCL, CB   M   Heart   55   C + A   60   Lymph node   II   +   CT + RT   PD   Death at 8 mo  
3522   DLBCL, CB   M   Liver   1   FK506   29   Jejunum   IIE  -   CT + S + anti-CD20   CR   Alive at 41 mo  
3523   DLBCL, CB   F   Heart   12   C + A   102   Lymph node   I   -   RT + anti-CD20   CR   Alive at 29 mo  
3524   DLBCL, CB   M   Heart   21   C + A   78   Skin   IV   -   CT   CR   Death at 12 mo  
3527   DLBCL, CB   M   Kidney   28   C + A   51   Lymph node   III   -   CT   NE   Death at 3 mo  
3528   DLBCL, CB   M   Heart   16   C + A   95   Lymph node   II   -   CT + anti-CD20   PR   Death at 4 mo  
3530   DLBCL, CB   M   Heart   58   C + A   144   Lymph node   II   -   RT + anti-CD20   CR   Alive at 15 mo  
2616   DLBCL, IB   F   Liver   39   C + A   63   Peritoneum   IV   +   CT + HDIg   CR   Alive at 60 mo  
2620   DLBCL, IB   M   Kidney   64   C + A   36   Liver   IV   +   NA   NA   Autoptic diagnosis  
2621   DLBCL, IB   M   Heart   56   C + A   5   Lung   IV   +   NA   NA   Autoptic diagnosis  
2799   DLBCL, IB   M   Heart   56   C + A   43   Skin   IV   +   CT + HDIg   SD   Death at 4 months  
2802   DLBCL, IB   M   Heart   45   C + A   28   Mediastinum   IV   +   CT + HDIg   PR   Death at 3 mo  
2803   DLBCL, IB   F   Kidney   49   C + A   64   Stomach   IIE  -   CT + S   CR   Death at 16 mo  
2892   DLBCL, IB   M   Heart   44   FK506 + A   42   Retroperitoneum   I   +   IFN + HDIg   CR   Alive at 137 mo  
2895   DLBCL, IB   M   Kidney   46   C + A   72   Lymph node   III   +   NA   NA   Autoptic diagnosis  
2911   DLBCL, IB   M   Heart   42   C + A   90   Heart   IE  +   CT   PR   Death at 3 mo  
2915   DLBCL, IB   M   Heart   56   C + A   56   Lymph node   II   +   CT   PR   Death at 1 mo  
3461   DLBCL, IB   M   Kidney   30   na   72   Tonsil   IIE  +   NK   NK   NK  
3469   DLBCL, IB   F   Kidney   26   na   90   Jejunum   IIE  -   NK   NK   NK  
           CT + S + RT + HDIg +    
3476   DLBCL, IB   M   Heart   53   C + A   108   Skin   IE  +   CTL   CR   Death at 38 mo  
3517   DLBCL, IB   M   Heart   49   C + A   84   Lymph node   IV   -   NA   NA   Autoptic diagnosis  
3520   DLBCL, IB   M   Kidney   15   C + P   156   Kidney   IE  +   CT + S + RT   PD   Death at 4 mo  
3525   DLBCL, IB   F   Kidney   21   C + A   108   Spleen   IV   -   CT   NE   Death at 1 mo  
3529   DLBCL, IB   F   Heart   6   C + A   72   Lymph node   III   +   CT + anti-CD20   CR   Alive at 21 mo  
2861   DLBCL, AP   M   Kidney   47   C + A   77   Lymph node   III   -   CT   PD   Death at 6 mo  
2913B   DLBCL, AP   M   Heart   38   C + A   158   Tonsil   IE  +   CT + RT   PD   Death at 10 mo  
3458   DLBCL, AP   F   Kidney   60   C + A   14   Skin   IV   +   CT + anti-CD20 + HDIg   PR   Death at 6 mo  
2617   BL/BLL   M   Heart   51   C + A   38   Lung   IV   +   NK   PD   Death at 10 d  
2890   BL/BLL   M   Heart   27   C + A   106   Tonsil   IE  -   CT + RT   PD   Death at 22 mo  
3463   BL/BLL   M   Heart   50   C + A   92   Skin   IV   +   CT + HDIg   CR   Alive at 57 mo  
3526
 		 BL/BLL
 		 M
 		 Heart
 		 5
 		 C + A
 		 94
 		 Jaw
 		 IE
 		 +
 		 CT + RT
 		 PR
 		 Death at 18 mo
 
Case
Histology
Sex
TX
Age at TX, y
Immune suppression
Interval from TX, mo
Tumor site
Stage
EBV
Treatment modalities*
Response
Outcome, mo from PTLD
2614   P-PTLD   M   Lung   46   C + A   5   Lung   IIE  +   CT   SD   Death at 1 mo  
2618   P-PTLD   M   Heart   67   C + A   6   Lung   IIE  +   No treatment   CR   Alive at 76 mo  
2913A   P-PTLD   M   Heart   38   C + A   152   Tonsil   IE  -   CT + RT   CR   Death at 16 mo  
2916   P-PTLD   M   Heart   54   C + A   6   Lung   IE  +   S   CR   Alive at 54 mo  
3462   P-PTLD   M   Liver   61   C + A   7   Liver   IE  +   NA   NA   Autoptic diagnosis  
3464   P-PTLD   M   Liver   59   C + A   5   Liver   IE  +   S + anti-CD20 + HDIg   CR   Alive at 27 mo  
3468   P-PTLD   M   Heart   53   C + A   2   Tongue   IE  +   No treatment   CR   Alive at 23 mo  
3471   P-PTLD   M   Liver   33   C + A   7   Liver   IV   +   CT + HDIg + RF   CR   Alive at 31 mo  
3515   P-PTLD   M   Heart   13   C + A   79   Lymph node   II   -   CT   PD   Death at 18 mo  
3516   P-PTLD   M   Heart   18   C + A   22   Lymph node   II   +   CT   NE   Death at 20 mo  
3519   P-PTLD   M   Heart   59   C + A   84   Lymph node   III   -   CT   NE   Death at 6 mo  
3521   P-PTLD   F   Heart   14   C + A   51   Lymph node   I   +   S   CR   Alive at 41 mo  
2798   DLBCL, CB   F   Kidney   58   C + A   103   Lymph node   II   -   CT + HDIg   CR   Alive at 45 mo  
2898   DLBCL, CB   M   Heart   34   C + A   81   Lymph node   III   -   CT + S + HDIg   CR   Alive at 52 mo  
2909   DLBCL, CB   M   Heart   59   C + A   44   Spleen   III   -   No treatment   PD   Death at 5 mo  
2912   DLBCL, CB   M   Heart   43   C + A   113   Mesenteric mass   II   -   CT   PR   Death at 15 mo  
2914   DLBCL, CB   M   Heart   48   C + A   110   Stomach   IV   -   CT   CR   Alive at 70 mo  
3459   DLBCL, CB   M   Lung   27   C + A   128   Lymph node   IV   +   CT + anti-CD20 + HDIg   CR   Alive at 25 mo  
3465   DLBCL, CB   F   Liver   55   C + A   95   Lymph node   III   -   CT   CR   Alive at 21 mo  
3466   DLBCL, CB   M   Liver   45   C + A   104   Skin   IE  -   CT + S   CR   Alive at 22 mo  
3467   DLBCL, CB   M   Heart   52   C + A   128   Lymph node   IV   +   P   NA   Death at 1 d  
3518   DLBCL, CB   M   Heart   55   C + A   60   Lymph node   II   +   CT + RT   PD   Death at 8 mo  
3522   DLBCL, CB   M   Liver   1   FK506   29   Jejunum   IIE  -   CT + S + anti-CD20   CR   Alive at 41 mo  
3523   DLBCL, CB   F   Heart   12   C + A   102   Lymph node   I   -   RT + anti-CD20   CR   Alive at 29 mo  
3524   DLBCL, CB   M   Heart   21   C + A   78   Skin   IV   -   CT   CR   Death at 12 mo  
3527   DLBCL, CB   M   Kidney   28   C + A   51   Lymph node   III   -   CT   NE   Death at 3 mo  
3528   DLBCL, CB   M   Heart   16   C + A   95   Lymph node   II   -   CT + anti-CD20   PR   Death at 4 mo  
3530   DLBCL, CB   M   Heart   58   C + A   144   Lymph node   II   -   RT + anti-CD20   CR   Alive at 15 mo  
2616   DLBCL, IB   F   Liver   39   C + A   63   Peritoneum   IV   +   CT + HDIg   CR   Alive at 60 mo  
2620   DLBCL, IB   M   Kidney   64   C + A   36   Liver   IV   +   NA   NA   Autoptic diagnosis  
2621   DLBCL, IB   M   Heart   56   C + A   5   Lung   IV   +   NA   NA   Autoptic diagnosis  
2799   DLBCL, IB   M   Heart   56   C + A   43   Skin   IV   +   CT + HDIg   SD   Death at 4 months  
2802   DLBCL, IB   M   Heart   45   C + A   28   Mediastinum   IV   +   CT + HDIg   PR   Death at 3 mo  
2803   DLBCL, IB   F   Kidney   49   C + A   64   Stomach   IIE  -   CT + S   CR   Death at 16 mo  
2892   DLBCL, IB   M   Heart   44   FK506 + A   42   Retroperitoneum   I   +   IFN + HDIg   CR   Alive at 137 mo  
2895   DLBCL, IB   M   Kidney   46   C + A   72   Lymph node   III   +   NA   NA   Autoptic diagnosis  
2911   DLBCL, IB   M   Heart   42   C + A   90   Heart   IE  +   CT   PR   Death at 3 mo  
2915   DLBCL, IB   M   Heart   56   C + A   56   Lymph node   II   +   CT   PR   Death at 1 mo  
3461   DLBCL, IB   M   Kidney   30   na   72   Tonsil   IIE  +   NK   NK   NK  
3469   DLBCL, IB   F   Kidney   26   na   90   Jejunum   IIE  -   NK   NK   NK  
           CT + S + RT + HDIg +    
3476   DLBCL, IB   M   Heart   53   C + A   108   Skin   IE  +   CTL   CR   Death at 38 mo  
3517   DLBCL, IB   M   Heart   49   C + A   84   Lymph node   IV   -   NA   NA   Autoptic diagnosis  
3520   DLBCL, IB   M   Kidney   15   C + P   156   Kidney   IE  +   CT + S + RT   PD   Death at 4 mo  
3525   DLBCL, IB   F   Kidney   21   C + A   108   Spleen   IV   -   CT   NE   Death at 1 mo  
3529   DLBCL, IB   F   Heart   6   C + A   72   Lymph node   III   +   CT + anti-CD20   CR   Alive at 21 mo  
2861   DLBCL, AP   M   Kidney   47   C + A   77   Lymph node   III   -   CT   PD   Death at 6 mo  
2913B   DLBCL, AP   M   Heart   38   C + A   158   Tonsil   IE  +   CT + RT   PD   Death at 10 mo  
3458   DLBCL, AP   F   Kidney   60   C + A   14   Skin   IV   +   CT + anti-CD20 + HDIg   PR   Death at 6 mo  
2617   BL/BLL   M   Heart   51   C + A   38   Lung   IV   +   NK   PD   Death at 10 d  
2890   BL/BLL   M   Heart   27   C + A   106   Tonsil   IE  -   CT + RT   PD   Death at 22 mo  
3463   BL/BLL   M   Heart   50   C + A   92   Skin   IV   +   CT + HDIg   CR   Alive at 57 mo  
3526
 		 BL/BLL
 		 M
 		 Heart
 		 5
 		 C + A
 		 94
 		 Jaw
 		 IE
 		 +
 		 CT + RT
 		 PR
 		 Death at 18 mo
 

TX indicates transplantation; P-PTLD, polymorphic PTLD; M, male; C, cyclosporine A; A, azathioprine; CT, chemotherapy (the regimen varied and was tailored to the patient's age, stage, and performance status); SD, stable disease; CR, complete remission; RT, radiotherapy; S, surgery; NA, not applicable; anti-CD20, rituximab; HDIg, high-dose immunoglobulin; RF, radiofrequency; PD, progressive disease; P, prednisone; NE, not evaluable; F, female; DLBCL, diffuse large B-cell lymphoma; CB, centroblastic; PR, partial remission; P, prednisone; FK506, tacrolimus; IB, immunoblastic; IFN, interferon; na, not available; NK, not known; CTL, cytotoxic T lymphocytes; AP, anaplastic; and BL/BLL, Burkitt lymphoma/Burkitt-like lymphoma.

*

All patients underwent reduction of immunosuppression, with the exception of cases 3528 and 3529 and cases in whom the diagnosis of PTLD was autoptic.

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