Response to treatment by genotype for 222 patients with multiple myeloma treated with ABCM or CVAMP/HDM
. | GSTP1 105 genotype . | . | . | . | . | ||
|---|---|---|---|---|---|---|---|
. | Ile/Ile, no.(%) . | Ile/Val, no.(%) . | Val/Val, no.(%) . | Total, no.(%) . | P* . | ||
| ABCM arm | |||||||
| Plateau reached | |||||||
| Yes | 32 (66) | 25 (78) | 17 (89) | 74 (74) | |||
| No | 16 (34) | 7 (22) | 2 (11) | 25 (25) | .04 | ||
| No. of courses ABCM prior to plateau | |||||||
| 6 or fewer | 21 (65) | 19 (76) | 16 (94) | 56 (76) | |||
| More than 6 | 11 (35) | 6 (24) | 1 (6) | 18 (24) | .03 | ||
| Time to plateau | |||||||
| 260 d or fewer | 12 (38) | 12 (48) | 11 (65) | 35 (47) | |||
| More than 260 d | 20 (62) | 13 (52) | 6 (35) | 39 (53) | .07 | ||
| CVAMP/HDM arm | |||||||
| Plateau reached | |||||||
| Yes | 40 (80) | 42 (82) | 15 (79) | 97 (81) | |||
| No | 9 (20) | 9 (18) | 4 (21) | 22 (19) | .86 | ||
| Time to plateau | |||||||
| Fewer than 260 d | 24 (60) | 19 (45) | 8 (53) | 51 (53) | |||
| More than 260 d | 16 (40) | 23 (55) | 7 (47) | 46 (47) | .41 | ||
| Transplant received | |||||||
| Yes | 45 (90) | 41 (80) | 15 (79) | 101 (84) | |||
| No | 5 (10) | 10 (20) | 4 (21) | 19 (16) | .17 | ||
. | GSTP1 105 genotype . | . | . | . | . | ||
|---|---|---|---|---|---|---|---|
. | Ile/Ile, no.(%) . | Ile/Val, no.(%) . | Val/Val, no.(%) . | Total, no.(%) . | P* . | ||
| ABCM arm | |||||||
| Plateau reached | |||||||
| Yes | 32 (66) | 25 (78) | 17 (89) | 74 (74) | |||
| No | 16 (34) | 7 (22) | 2 (11) | 25 (25) | .04 | ||
| No. of courses ABCM prior to plateau | |||||||
| 6 or fewer | 21 (65) | 19 (76) | 16 (94) | 56 (76) | |||
| More than 6 | 11 (35) | 6 (24) | 1 (6) | 18 (24) | .03 | ||
| Time to plateau | |||||||
| 260 d or fewer | 12 (38) | 12 (48) | 11 (65) | 35 (47) | |||
| More than 260 d | 20 (62) | 13 (52) | 6 (35) | 39 (53) | .07 | ||
| CVAMP/HDM arm | |||||||
| Plateau reached | |||||||
| Yes | 40 (80) | 42 (82) | 15 (79) | 97 (81) | |||
| No | 9 (20) | 9 (18) | 4 (21) | 22 (19) | .86 | ||
| Time to plateau | |||||||
| Fewer than 260 d | 24 (60) | 19 (45) | 8 (53) | 51 (53) | |||
| More than 260 d | 16 (40) | 23 (55) | 7 (47) | 46 (47) | .41 | ||
| Transplant received | |||||||
| Yes | 45 (90) | 41 (80) | 15 (79) | 101 (84) | |||
| No | 5 (10) | 10 (20) | 4 (21) | 19 (16) | .17 | ||
Chi-square test for linear trend.