Summary of hematopoietic response to PT-100 in normal mice
. | Treatment in vivo . | . | . | |
|---|---|---|---|---|
. | Saline . | PT-100 . | P . | |
| Frequency per 106 splenic mononuclear cells | ||||
| CFU-Es | 735 ± 144 | 1547 ± 250 | .00713 | |
| BFU-Es | 355 ± 71 | 620 ± 119 | .03828 | |
| CFU-GMs | 370 ± 59 | 636 ± 83 | .00851 | |
| No. per spleen | ||||
| Mononuclear cells, ×10-6 | 41.2 ± 3.0 | 75.1 ± 5.8 | .00016 | |
| CFU-Es, ×10-4 | 3.3 ± 0.7 | 11.1 ± 1.8 | .00068 | |
| BFU-Es, ×10-4 | 1.5 ± 0.3 | 4.2 ± 0.5 | .00010 | |
| CFU-GMs, ×10-4 | 1.5 ± 0.8 | 4.4 ± 0.4 | < .00005 | |
. | Treatment in vivo . | . | . | |
|---|---|---|---|---|
. | Saline . | PT-100 . | P . | |
| Frequency per 106 splenic mononuclear cells | ||||
| CFU-Es | 735 ± 144 | 1547 ± 250 | .00713 | |
| BFU-Es | 355 ± 71 | 620 ± 119 | .03828 | |
| CFU-GMs | 370 ± 59 | 636 ± 83 | .00851 | |
| No. per spleen | ||||
| Mononuclear cells, ×10-6 | 41.2 ± 3.0 | 75.1 ± 5.8 | .00016 | |
| CFU-Es, ×10-4 | 3.3 ± 0.7 | 11.1 ± 1.8 | .00068 | |
| BFU-Es, ×10-4 | 1.5 ± 0.3 | 4.2 ± 0.5 | .00010 | |
| CFU-GMs, ×10-4 | 1.5 ± 0.8 | 4.4 ± 0.4 | < .00005 | |
BALB/c mice were orally administered either saline or a 5-μg dose of PT-100 twice a day for 5 days. Values represent mean ± SEM. Saline treatment, n = 11; PT-100 treatment, n = 12. P values were determined by Student t test.