Fifty-four pediatric AML patients enrolled in this study
Patient . | Age . | Sex . | FAB subtype . | Karyotype . | Outcome . | EFS, mo . | SCT . |
|---|---|---|---|---|---|---|---|
| GP1 | 10 y | M | M4 | 46XY | CR | 61.9 | + |
| GP2 | 6 mo | M | M4 | 46XY, t(11;12)(q23;q13) | CR | 40.8 | + |
| GP3 | 10 y 7 mo | M | M2 | 46XY,t(8;21) | CR | 85.5 | - |
| GP4 | 6 y 6 mo | M | M2 | 46XY,t(8;21) | CR | 37.3 | - |
| GP5 | 3 mo | M | M4 | 46XY,t(11;19)(q23;p13) | CR | 68.7 | + |
| GP6 | 3 d | M | M5 | 46XY | CR | 57.3 | + |
| GP7 | 10 mo | M | M4 | 46XY,inv(16)(p13q22) | CR | 49.9 | - |
| GP8 | 7 mo | M | M4 | 46XY | CR | 41.9 | - |
| GP9 | 12 y | M | M2 | 46XY,t(6;9)(p23;q34),add(21)(q22) | CR | 48.9 | + |
| PP1 | 10 y 1 mo | M | M4 | 46XY,inv(16) | R | 12.0 | + |
| PP2 | 22 d | F | Mixed | 46XX,t(4;11) | R | 1.0 | - |
| PP3 | 8 y 2 mo | M | M5 | 47XY,+8 | R | 9.5 | + |
| PP4 | 5 mo | M | Mixed | 47XY,+19 | IF | 1.0 | - |
| PP5 | 7 mo | M | M7 | 45XY,-16 | R | 3.0 | - |
| PP6 | 1 y | M | M2 | 46XY,inv(1)(p12;q36),addX(q26) | R | 3.4 | + |
| PP7 | 0 d | F | M5 | 46XX,t(4;11)(q21;q23) | R | 1.0 | - |
| PP8 | 1 y 7 mo | M | M7 | 46XY,t(6;22;17)(p23;q11;q12),t(12;21)(p11.2;q22) | R | 4.9 | - |
| PP9 | 13 y 6 mo | M | M2 | 46XY,t(8;21) | R | 11.7 | + |
| S1 | 4 y | M | M2 | 46XY,t(8;21) | R | 11.6 | + |
| S2 | 14 y 2 mo | F | M5 | 47XX,+21 | R | 18.2 | - |
| S3 | 6 y 7 mo | M | M5 | 46XY,t(6;11)(q25;q23) | R | 15.1 | + |
| S4 | 15 y | M | M2 | 46XY,t(9;22)(q34;q11) | R | 7.4 | + |
| S5 | 1 y | F | M5 | 46XX,t(11;19)(q23;p13.1),+der(6)t(6;8)(p21.3;q22), -6 | R | 29.1 | - |
| S6 | 11 mo | F | M7 | 46XX | R | 27.0 | - |
| S7 | 5 y 10 mo | F | M2 | 46XX,t(8;21) | R | 19.0 | + |
| S8 | 6 mo | M | M7 | 46XY,del(6)(q13) | R | 4.1 | + |
| S9 | 4 mo | F | M4 | 46XX,t(9;11)(p22;q23) | R | 21.2 | - |
| S10 | 17 d | F | M5 | NA | CR | 36.4 | - |
| S11 | 8 y | M | M2 | 45X, -Y,t(8;21)(q22;q22) | CR | 70.2 | - |
| S12 | 2 y | F | M4 | 46XX,inv(16) | CR | 22.3 | - |
| S13 | 3 mo | M | M5 | 46XY,t(9;11)(p22;q23) | CR | 20.2 | - |
| S14 | 12 y | M | M2 | 46XY,t(8;21) | CR | 11.1 | - |
| S15 | 12 y | F | M2 | 46XX,t(8;21) | CR | 3.7 | - |
| S16 | 9 mo | M | M4 | 46XY,inv(16)(p13;q22) | R | 4.9 | + |
| S17 | NA | M | M5 | NA | R | 4.0 | - |
| S18 | 1 y 9 mo | M | M7 | 47XY, +21 | R | 0.6 | - |
| S19 | 7 mo | F | M4 | 46XX | CR | 41.0 | - |
| S20 | 1 y 11 mo | M | M5 | NA | CR | 52.9 | - |
| S21 | 10 mo | M | M4 | 46XY,t(6;11)(q27;q23) | R | 4.2 | + |
| S22 | 3 mo | F | M5 | 46XX,t(11;19) | CR | 41.0 | - |
| S23 | 9 mo | F | M5 | 46XX,t(9;11)(p22;q23) | CR | 62.2 | - |
| S24 | 4 y | F | M5 | 50XXX, +6, +8, +18,del(11)(q21;q23)—11q23(-)* | R | 9.6 | - |
| S25 | 9 mo | M | M5 | 46XY,add(X)(q27)—11q23(+)* | R | 1.0 | - |
| S26 | 10 y | F | M4 | 46XX,inv(9)(p11;q13),inv(16)(p13;q22) | CR | 68.4 | - |
| S27 | 1 y 11 mo | F | M7 | NA | CR | 18.4 | - |
| S28 | NA | F | M5 | NA | R | 19.0 | - |
| S29 | 5 mo | M | M5 | NA | CR | 66.1 | - |
| S30 | 6 d | F | M0 | 46XX,add(7)(q22),del(12)(p13) | CR | 31.1 | - |
| S31 | 2 mo | M | M7 | 49XY,+19,+21,+22 | CR | 68.7 | - |
| S32 | 1 y 4 mo | F | M5 | 46XX,t(9;11) | R | 17.1 | - |
| S33 | 10 mo | M | M7 | 47XY,+21 | CR | 54.9 | - |
| S34 | NA | F | M5 | NA | CR | 13.9 | - |
| S35 | 6 mo | M | M5 | NA | CR | 27.2 | - |
| S36 | NA | F | M2 | NA | CR | 24.0 | - |
Patient . | Age . | Sex . | FAB subtype . | Karyotype . | Outcome . | EFS, mo . | SCT . |
|---|---|---|---|---|---|---|---|
| GP1 | 10 y | M | M4 | 46XY | CR | 61.9 | + |
| GP2 | 6 mo | M | M4 | 46XY, t(11;12)(q23;q13) | CR | 40.8 | + |
| GP3 | 10 y 7 mo | M | M2 | 46XY,t(8;21) | CR | 85.5 | - |
| GP4 | 6 y 6 mo | M | M2 | 46XY,t(8;21) | CR | 37.3 | - |
| GP5 | 3 mo | M | M4 | 46XY,t(11;19)(q23;p13) | CR | 68.7 | + |
| GP6 | 3 d | M | M5 | 46XY | CR | 57.3 | + |
| GP7 | 10 mo | M | M4 | 46XY,inv(16)(p13q22) | CR | 49.9 | - |
| GP8 | 7 mo | M | M4 | 46XY | CR | 41.9 | - |
| GP9 | 12 y | M | M2 | 46XY,t(6;9)(p23;q34),add(21)(q22) | CR | 48.9 | + |
| PP1 | 10 y 1 mo | M | M4 | 46XY,inv(16) | R | 12.0 | + |
| PP2 | 22 d | F | Mixed | 46XX,t(4;11) | R | 1.0 | - |
| PP3 | 8 y 2 mo | M | M5 | 47XY,+8 | R | 9.5 | + |
| PP4 | 5 mo | M | Mixed | 47XY,+19 | IF | 1.0 | - |
| PP5 | 7 mo | M | M7 | 45XY,-16 | R | 3.0 | - |
| PP6 | 1 y | M | M2 | 46XY,inv(1)(p12;q36),addX(q26) | R | 3.4 | + |
| PP7 | 0 d | F | M5 | 46XX,t(4;11)(q21;q23) | R | 1.0 | - |
| PP8 | 1 y 7 mo | M | M7 | 46XY,t(6;22;17)(p23;q11;q12),t(12;21)(p11.2;q22) | R | 4.9 | - |
| PP9 | 13 y 6 mo | M | M2 | 46XY,t(8;21) | R | 11.7 | + |
| S1 | 4 y | M | M2 | 46XY,t(8;21) | R | 11.6 | + |
| S2 | 14 y 2 mo | F | M5 | 47XX,+21 | R | 18.2 | - |
| S3 | 6 y 7 mo | M | M5 | 46XY,t(6;11)(q25;q23) | R | 15.1 | + |
| S4 | 15 y | M | M2 | 46XY,t(9;22)(q34;q11) | R | 7.4 | + |
| S5 | 1 y | F | M5 | 46XX,t(11;19)(q23;p13.1),+der(6)t(6;8)(p21.3;q22), -6 | R | 29.1 | - |
| S6 | 11 mo | F | M7 | 46XX | R | 27.0 | - |
| S7 | 5 y 10 mo | F | M2 | 46XX,t(8;21) | R | 19.0 | + |
| S8 | 6 mo | M | M7 | 46XY,del(6)(q13) | R | 4.1 | + |
| S9 | 4 mo | F | M4 | 46XX,t(9;11)(p22;q23) | R | 21.2 | - |
| S10 | 17 d | F | M5 | NA | CR | 36.4 | - |
| S11 | 8 y | M | M2 | 45X, -Y,t(8;21)(q22;q22) | CR | 70.2 | - |
| S12 | 2 y | F | M4 | 46XX,inv(16) | CR | 22.3 | - |
| S13 | 3 mo | M | M5 | 46XY,t(9;11)(p22;q23) | CR | 20.2 | - |
| S14 | 12 y | M | M2 | 46XY,t(8;21) | CR | 11.1 | - |
| S15 | 12 y | F | M2 | 46XX,t(8;21) | CR | 3.7 | - |
| S16 | 9 mo | M | M4 | 46XY,inv(16)(p13;q22) | R | 4.9 | + |
| S17 | NA | M | M5 | NA | R | 4.0 | - |
| S18 | 1 y 9 mo | M | M7 | 47XY, +21 | R | 0.6 | - |
| S19 | 7 mo | F | M4 | 46XX | CR | 41.0 | - |
| S20 | 1 y 11 mo | M | M5 | NA | CR | 52.9 | - |
| S21 | 10 mo | M | M4 | 46XY,t(6;11)(q27;q23) | R | 4.2 | + |
| S22 | 3 mo | F | M5 | 46XX,t(11;19) | CR | 41.0 | - |
| S23 | 9 mo | F | M5 | 46XX,t(9;11)(p22;q23) | CR | 62.2 | - |
| S24 | 4 y | F | M5 | 50XXX, +6, +8, +18,del(11)(q21;q23)—11q23(-)* | R | 9.6 | - |
| S25 | 9 mo | M | M5 | 46XY,add(X)(q27)—11q23(+)* | R | 1.0 | - |
| S26 | 10 y | F | M4 | 46XX,inv(9)(p11;q13),inv(16)(p13;q22) | CR | 68.4 | - |
| S27 | 1 y 11 mo | F | M7 | NA | CR | 18.4 | - |
| S28 | NA | F | M5 | NA | R | 19.0 | - |
| S29 | 5 mo | M | M5 | NA | CR | 66.1 | - |
| S30 | 6 d | F | M0 | 46XX,add(7)(q22),del(12)(p13) | CR | 31.1 | - |
| S31 | 2 mo | M | M7 | 49XY,+19,+21,+22 | CR | 68.7 | - |
| S32 | 1 y 4 mo | F | M5 | 46XX,t(9;11) | R | 17.1 | - |
| S33 | 10 mo | M | M7 | 47XY,+21 | CR | 54.9 | - |
| S34 | NA | F | M5 | NA | CR | 13.9 | - |
| S35 | 6 mo | M | M5 | NA | CR | 27.2 | - |
| S36 | NA | F | M2 | NA | CR | 24.0 | - |
EFFS indicates event-free survival; SCT, stem cell transplantation; NA, no available data; CR, not relapsed (complete remission), R, relapsed; IF, induction failure; and -, patients without SCT.
S24 had del(11)(q21;q23), but MLL gene rearrangement was not detected by Southern hybridization analysis; thus, this patient was judged as 11q23 rearrangement-negative. S25 did not show any 11q23 rearrangement by karyotyping, but MLL gene rearrangement was detected by Southern hybridization analysis; thus, this patient was judged as 11q23 rearrangement-positive.