Table 1.

Comparison of leukocytosis and neutrophilia between selectin-perturbed KO mice



Fold increase in cell numbers compared with control mice
Blood cell types
β4GalT-1 KO
Core 2 β6GnT KO
E/P-selectin KO
Fuc-TVII KO
Fuc-TIV/VII KO
Leukocytes   2.2   2.4   3.9   3.2   2.9  
Neutrophils   2.3   4.3   16.6   7.4   18.4  
Lymphocytes   2.5   1.6   1.5   2.0   1.2  
Monocytes
 
1.6
 
1.4
 
9.8
 
2.9
 
4.2
 


Fold increase in cell numbers compared with control mice
Blood cell types
β4GalT-1 KO
Core 2 β6GnT KO
E/P-selectin KO
Fuc-TVII KO
Fuc-TIV/VII KO
Leukocytes   2.2   2.4   3.9   3.2   2.9  
Neutrophils   2.3   4.3   16.6   7.4   18.4  
Lymphocytes   2.5   1.6   1.5   2.0   1.2  
Monocytes
 
1.6
 
1.4
 
9.8
 
2.9
 
4.2
 

Data are from core 2 β6GnT-deficient mice,11  E- and P-selectin double-deficient mice,30  Fuc-TVII-deficient mice,13  and Fuc-TIV/VII double-deficient mice.14 

KO indicates knockout.

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