Clinical characteristics of patients
. | Group 1, CBT . | Group 2, BMT . | P . |
|---|---|---|---|
| Patient age, mo (range) | 63 (3-180) | 88 (30-152) | NS |
| Patient sex, M/F | 6/6 | 7/5 | NS |
| Donor age, y (range) | 0 | 25 (2-46) | — |
| Donor sex (M/F) | 9/3 | 7/5 | NS |
| Type of donor | 7 RD/5 UD | 6 RD/6 UD | NS |
| Original disorders | |||
| Acute leukemia | 6 | 6 | NS |
| Chronic leukemia | 0 | 2 | |
| Thalassemia major | 5 | 4 | |
| SCID | 1 | 0 | |
| Conditioning regimen | |||
| TBI + chemotherapy | 4 | 5 | NS |
| Busulfan + chemotherapy | 8 | 7 | |
| No. of cells infused, × 107/kg (range) | 3.7 (1.9-18) | 50 (21-126) | .0001 |
| PMNs more than 0.5 × 109/L, d (range) | 22.5 (16-39) | 13 (9-23) | .0002 |
| PLTs more than 50 × 109/L, d (range) | 47.5 (30-100) | 27 (21-58) | .0007 |
| Grade II-IV acute GVHD | 3 of 12 | 6 of 12 | NS |
| Limited chronic GVHD | 0 of 12 | 2 of 12 | NS |
| HCMV infection | 2 of 12 | 4 of 12 | NS |
. | Group 1, CBT . | Group 2, BMT . | P . |
|---|---|---|---|
| Patient age, mo (range) | 63 (3-180) | 88 (30-152) | NS |
| Patient sex, M/F | 6/6 | 7/5 | NS |
| Donor age, y (range) | 0 | 25 (2-46) | — |
| Donor sex (M/F) | 9/3 | 7/5 | NS |
| Type of donor | 7 RD/5 UD | 6 RD/6 UD | NS |
| Original disorders | |||
| Acute leukemia | 6 | 6 | NS |
| Chronic leukemia | 0 | 2 | |
| Thalassemia major | 5 | 4 | |
| SCID | 1 | 0 | |
| Conditioning regimen | |||
| TBI + chemotherapy | 4 | 5 | NS |
| Busulfan + chemotherapy | 8 | 7 | |
| No. of cells infused, × 107/kg (range) | 3.7 (1.9-18) | 50 (21-126) | .0001 |
| PMNs more than 0.5 × 109/L, d (range) | 22.5 (16-39) | 13 (9-23) | .0002 |
| PLTs more than 50 × 109/L, d (range) | 47.5 (30-100) | 27 (21-58) | .0007 |
| Grade II-IV acute GVHD | 3 of 12 | 6 of 12 | NS |
| Limited chronic GVHD | 0 of 12 | 2 of 12 | NS |
| HCMV infection | 2 of 12 | 4 of 12 | NS |
SCID indicates severe combined immunodeficiency; TBI, total body irradiation; PMN, polymorphonuclear granulocytes; PLT platelets; HCMV, human cytomegalovirus; NS, not significant; —, not applicable; RD, related donor; and UD, unrelated donor