Table 2.

Chromosomal abnormalities in dominant-negative hTERT-transduced CD4+ T cells

DNA construct used for CD4+ T-cell transduction
No. of metaphases analyzed
No. of metaphases with dicentric chromosomes
GFP   28   0  
DN-hTERT-GFP   16   3* 
hTERT-GFP
 		 20
 		 0
 
DNA construct used for CD4+ T-cell transduction
No. of metaphases analyzed
No. of metaphases with dicentric chromosomes
GFP   28   0  
DN-hTERT-GFP   16   3* 
hTERT-GFP
 		 20
 		 0
 
*

Chromosome end-to-end fusions found: (1q;20q) (7p;22p) (6q;10p)

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