Patient characteristics according to bcl-2 expression and treatment
. | LNH-98-5 . | Study population . | . | bcl-2+ . | . | bcl-2- . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | n = 399 . | CHOP n = 137 . | R-CHOP n = 155 . | CHOP n = 92 . | R-CHOP n = 101 . | CHOP n = 45 . | R-CHOP n = 54 . | |||
| Sex | ||||||||||
| Male (%) | 199 (50) | 70 (51) | 68 (44) | 50 (54) | 45 (45) | 20 (44) | 23 (43) | |||
| Female (%) | 200 (50) | 67 (49) | 87 (56) | 42 (46) | 56 (55) | 25 (56) | 31 (57) | |||
| Median age, y (range) | 69 (60-80) | 68 (60-80) | 69 (60-80) | 69 (60-80) | 70 (60-80) | 66 (60-80) | 67 (60-79) | |||
| LDH | ||||||||||
| Equal to or less than N (%) | 136 (34) | 42 (31) | 52 (34) | 28 (30) | 30 (30) | 14 (31) | 22 (41) | |||
| Greater than N (%) | 263 (66) | 95 (60) | 103 (67) | 64 (70%) | 71 (70) | 31 (69) | 32 (59) | |||
| Stage | ||||||||||
| I-II (%) | 81 (20) | 28 (20) | 33 (21) | 21 (23) | 21 (21) | 7 (16) | 12 (22) | |||
| III-IV (%) | 318 (80) | 109 (80) | 122 (79) | 71 (77) | 80 (79) | 38 (84) | 42 (78) | |||
| PS | ||||||||||
| 0-1 (%) | 321 (80) | 112 (82) | 120 (78) | 78 (85) | 78 (77) | 34 (76) | 42 (78) | |||
| 2-4 (%) | 78 (20) | 25 (18) | 35 (22) | 14 (15) | 23 (23) | 11 (24) | 12 (22) | |||
| Extra nodal sites | ||||||||||
| 0-1 (%) | 287 (72) | 100 (73) | 110 (71) | 69 (75) | 77 (75) | 31 (70) | 33 (62) | |||
| 2 or more (%) | 112 (28) | 37 (27) | 45 (29) | 23 (25) | 24 (25) | 14 (30) | 21 (38) | |||
| aa-IPI | ||||||||||
| 0 (%) | 41 (10) | 13 (9) | 15 (9) | 12 (13) | 7 (7) | 1 (2) | 8 (15) | |||
| 1 (%) | 117 (29) | 39 (29) | 48 (31) | 23 (25) | 34 (34) | 16 (36) | 14 (26) | |||
| 2 (%) | 181 (45) | 65 (47) | 64 (41) | 45 (49) | 40 (40) | 20 (44) | 24 (44) | |||
| 3 (%) | 60 (16) | 20 (18) | 28 (18) | 12 (13) | 20 (20) | 8 (18) | 8 (15) | |||
| β2-microglobulin | ||||||||||
| Equal to or less than N (%) | 147 (42) | 50 (41) | 58 (44) | 35 (42) | 37 (43) | 15 (41) | 21 (48) | |||
| Greater than N (%) | 201 (58) | 71 (59) | 72 (56) | 49 (58) | 50 (57) | 22 (59) | 22 (52) | |||
| Bone marrow | ||||||||||
| Normal (%) | 285 (73) | 103 (76) | 117 (76) | 72 (79) | 77 (77) | 31 (71) | 40 (74) | |||
| Involved (%) | 107 (27) | 32 (24) | 37 (24) | 19 (21) | 23 (23) | 13 (29) | 14 (26) | |||
. | LNH-98-5 . | Study population . | . | bcl-2+ . | . | bcl-2- . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | n = 399 . | CHOP n = 137 . | R-CHOP n = 155 . | CHOP n = 92 . | R-CHOP n = 101 . | CHOP n = 45 . | R-CHOP n = 54 . | |||
| Sex | ||||||||||
| Male (%) | 199 (50) | 70 (51) | 68 (44) | 50 (54) | 45 (45) | 20 (44) | 23 (43) | |||
| Female (%) | 200 (50) | 67 (49) | 87 (56) | 42 (46) | 56 (55) | 25 (56) | 31 (57) | |||
| Median age, y (range) | 69 (60-80) | 68 (60-80) | 69 (60-80) | 69 (60-80) | 70 (60-80) | 66 (60-80) | 67 (60-79) | |||
| LDH | ||||||||||
| Equal to or less than N (%) | 136 (34) | 42 (31) | 52 (34) | 28 (30) | 30 (30) | 14 (31) | 22 (41) | |||
| Greater than N (%) | 263 (66) | 95 (60) | 103 (67) | 64 (70%) | 71 (70) | 31 (69) | 32 (59) | |||
| Stage | ||||||||||
| I-II (%) | 81 (20) | 28 (20) | 33 (21) | 21 (23) | 21 (21) | 7 (16) | 12 (22) | |||
| III-IV (%) | 318 (80) | 109 (80) | 122 (79) | 71 (77) | 80 (79) | 38 (84) | 42 (78) | |||
| PS | ||||||||||
| 0-1 (%) | 321 (80) | 112 (82) | 120 (78) | 78 (85) | 78 (77) | 34 (76) | 42 (78) | |||
| 2-4 (%) | 78 (20) | 25 (18) | 35 (22) | 14 (15) | 23 (23) | 11 (24) | 12 (22) | |||
| Extra nodal sites | ||||||||||
| 0-1 (%) | 287 (72) | 100 (73) | 110 (71) | 69 (75) | 77 (75) | 31 (70) | 33 (62) | |||
| 2 or more (%) | 112 (28) | 37 (27) | 45 (29) | 23 (25) | 24 (25) | 14 (30) | 21 (38) | |||
| aa-IPI | ||||||||||
| 0 (%) | 41 (10) | 13 (9) | 15 (9) | 12 (13) | 7 (7) | 1 (2) | 8 (15) | |||
| 1 (%) | 117 (29) | 39 (29) | 48 (31) | 23 (25) | 34 (34) | 16 (36) | 14 (26) | |||
| 2 (%) | 181 (45) | 65 (47) | 64 (41) | 45 (49) | 40 (40) | 20 (44) | 24 (44) | |||
| 3 (%) | 60 (16) | 20 (18) | 28 (18) | 12 (13) | 20 (20) | 8 (18) | 8 (15) | |||
| β2-microglobulin | ||||||||||
| Equal to or less than N (%) | 147 (42) | 50 (41) | 58 (44) | 35 (42) | 37 (43) | 15 (41) | 21 (48) | |||
| Greater than N (%) | 201 (58) | 71 (59) | 72 (56) | 49 (58) | 50 (57) | 22 (59) | 22 (52) | |||
| Bone marrow | ||||||||||
| Normal (%) | 285 (73) | 103 (76) | 117 (76) | 72 (79) | 77 (77) | 31 (71) | 40 (74) | |||
| Involved (%) | 107 (27) | 32 (24) | 37 (24) | 19 (21) | 23 (23) | 13 (29) | 14 (26) | |||
N indicates normal.