ATM allelic status, TP53 mutations, and INK4a/ARF deletions in lymphoid neoplasms withATM class I and class II variants
| Tumor . | ATMvariant . | ATM allelic status . | TP53mutation3-150 . | INK4a/ARF deletion3-151 . |
|---|---|---|---|---|
| Class I variants | ||||
| DLBCL-22 | R3008H | NI | — | — |
| DLBCL-26 | R2151G3-152 | LOH | — | — |
| DLBCL-47 | H1380Y | LOH | R158C | — |
| DLBCL-70 | P604S | NI | IVS4nt-1G>A | — |
| DLBCL-101 | G3051V | LOH | — | Exons 1β and 2 |
| DLBCL-141 | H996Q | NI | R273H | — |
| 735C>T3-153,3-155 | ||||
| DLBCL-144 | I1407S | LOH | Y220C | Exons 1β and 2 |
| DLBCL-230 | Q2593X | LOH | P151S | — |
| DLBCL-274 | E466X | — | — | Exons 1β and 2 |
| G2063E | ||||
| FL-18 | M2616I | — | I254N | — |
| P1054R3-155 | ||||
| FL-134 | G2023R | — | — | — |
| F858L3-155 | ||||
| ALL-A22 | F570S | — | — | ND |
| Class II variants | ||||
| DLBCL-2 | 735C>T3-153 | NI | — | — |
| L1420F | ||||
| DLBCL-43 | N1853V | — | — | — |
| DLBCL-133 | 735C>T3-153 | NI | — | Exons 1β and 2 |
| DLBCL-139 | S49C | NI | — | — |
| DLBCL-152 | 735C>T3-153 | LOH | — | — |
| DLBCL-157 | P1054R | — | — | — |
| F858L | ||||
| DLBCL-159 | N1853V | — | R248Q | — |
| DLBCL-234 | S49C | NI | R248W | ND |
| 735C>T3-153 | ||||
| DLBCL-270 | L1420F | — | — | — |
| FL-4 | S707P | — | — | — |
| FL-45 | 735C>T3-153 | NI | — | — |
| FL-49 | S707P | — | — | — |
| FL-123 | P1054R | — | — | — |
| FL-142 | 735C>T3-153 | — | — | — |
| FL-218 | S707P | — | — | ND |
| FL-220 | P1054R | — | — | — |
| PTL-12 | 735C>T3-153 | — | — | — |
| PTL-160 | S707P | — | — | — |
| PTL-244 | 735C>T3-153 | — | — | — |
| PTL-256 | F858L | — | ND | — |
| P1054R | ||||
| ALL-A3 | F858L | NI | — | ND |
| ALL-A27 | P1054R | — | — | ND |
| ALL-A28 | 735C>T3-153 | — | R175H | ND |
| Tumor . | ATMvariant . | ATM allelic status . | TP53mutation3-150 . | INK4a/ARF deletion3-151 . |
|---|---|---|---|---|
| Class I variants | ||||
| DLBCL-22 | R3008H | NI | — | — |
| DLBCL-26 | R2151G3-152 | LOH | — | — |
| DLBCL-47 | H1380Y | LOH | R158C | — |
| DLBCL-70 | P604S | NI | IVS4nt-1G>A | — |
| DLBCL-101 | G3051V | LOH | — | Exons 1β and 2 |
| DLBCL-141 | H996Q | NI | R273H | — |
| 735C>T3-153,3-155 | ||||
| DLBCL-144 | I1407S | LOH | Y220C | Exons 1β and 2 |
| DLBCL-230 | Q2593X | LOH | P151S | — |
| DLBCL-274 | E466X | — | — | Exons 1β and 2 |
| G2063E | ||||
| FL-18 | M2616I | — | I254N | — |
| P1054R3-155 | ||||
| FL-134 | G2023R | — | — | — |
| F858L3-155 | ||||
| ALL-A22 | F570S | — | — | ND |
| Class II variants | ||||
| DLBCL-2 | 735C>T3-153 | NI | — | — |
| L1420F | ||||
| DLBCL-43 | N1853V | — | — | — |
| DLBCL-133 | 735C>T3-153 | NI | — | Exons 1β and 2 |
| DLBCL-139 | S49C | NI | — | — |
| DLBCL-152 | 735C>T3-153 | LOH | — | — |
| DLBCL-157 | P1054R | — | — | — |
| F858L | ||||
| DLBCL-159 | N1853V | — | R248Q | — |
| DLBCL-234 | S49C | NI | R248W | ND |
| 735C>T3-153 | ||||
| DLBCL-270 | L1420F | — | — | — |
| FL-4 | S707P | — | — | — |
| FL-45 | 735C>T3-153 | NI | — | — |
| FL-49 | S707P | — | — | — |
| FL-123 | P1054R | — | — | — |
| FL-142 | 735C>T3-153 | — | — | — |
| FL-218 | S707P | — | — | ND |
| FL-220 | P1054R | — | — | — |
| PTL-12 | 735C>T3-153 | — | — | — |
| PTL-160 | S707P | — | — | — |
| PTL-244 | 735C>T3-153 | — | — | — |
| PTL-256 | F858L | — | ND | — |
| P1054R | ||||
| ALL-A3 | F858L | NI | — | ND |
| ALL-A27 | P1054R | — | — | ND |
| ALL-A28 | 735C>T3-153 | — | R175H | ND |
NI indicates not informative; ND, not done; LOH, loss of heterozygosity.
Three DLBCLs and 1 FL carried TP53 mutations without detectable ATM sequence variants.
Three DLBCLs and 1 FL carried INK4a/ARFdeletions without detectable ATM sequence variants.
Associated with skipping of exon 46.
Associated with skipping of exon 9.
Class II variant.