Table 1. Alternative anticoagulants to... | American Society of Hematology

Table 1.

Alternative anticoagulants to heparin for patients with HIT

	Danaparoid sodium	Argatroban	Lepirudin
Composition	Dermatan sulfate	Synthetic arginine analogue	Recombinant protein
	Heparan sulfate
	Chondroitin sulfate
Molecular weight, Da	6000	506	6979
Action	Inhibits factor Xa and thrombin through antithrombin	Direct thrombin inhibitor	Direct thrombin inhibitor
Half-life
Healthy volunteer	22 h	40 min	1.5 h
Hepatic disease	Normal	Prolonged	Normal
Renal disease	Prolonged	Normal	Prolonged
Monitoring	None or antifactor Xa assay	aPTT	aPTT
Effect on PT	None	Prolongation	Prolongation
Neutralization	None	None	None
Excretion	Renal	Liver	Renal
Immune effects	Occasional antibodies to PF4	None known	Antibodies to drug cause prolonged half-life

	Danaparoid sodium	Argatroban	Lepirudin
Composition	Dermatan sulfate	Synthetic arginine analogue	Recombinant protein
	Heparan sulfate
	Chondroitin sulfate
Molecular weight, Da	6000	506	6979
Action	Inhibits factor Xa and thrombin through antithrombin	Direct thrombin inhibitor	Direct thrombin inhibitor
Half-life
Healthy volunteer	22 h	40 min	1.5 h
Hepatic disease	Normal	Prolonged	Normal
Renal disease	Prolonged	Normal	Prolonged
Monitoring	None or antifactor Xa assay	aPTT	aPTT
Effect on PT	None	Prolongation	Prolongation
Neutralization	None	None	None
Excretion	Renal	Liver	Renal
Immune effects	Occasional antibodies to PF4	None known	Antibodies to drug cause prolonged half-life