Outcome of remission induction therapy
| . | ADE (n = 61) . | ADEP (n = 59) . | Total (n = 120) . | P4-150 . |
|---|---|---|---|---|
| Outcome for all patients | ||||
| CR | 28 (46%) | 23 (39%) | 51 (43%) | .008 (3 × 2) |
| NR | 21 (34%) | 10 (17%) | 31 (26%) | .47 (2 × 2) |
| Death | 12 (20%) | 26 (44%) | 38 (32%) | |
| Death within 30 d | 7 | 19 | 26 | |
| Death within 31-67 d4-151 | 5 | 7 | 12 | |
| No. of inductions | ||||
| None‡ | 2 | 0 | 2 | .48 |
| 1 | 50 | 52 | 102 | |
| 2 | 9 | 7 | 16 | |
| Outcome for patients receiving 1 induction course | ||||
| CR | 27 (54%) | 23 (44%) | 50 (49%) | .79 (3 × 2) |
| NR | 14 (28%) | 7 (13%) | 21 (21%) | 1.00 (2 × 2) |
| Death | 9 (18%) | 22 (42%) | 31 (30%) | |
| Death within 30 d | 7 | 17 | 24 | |
| Death within 31-67 d | 2 | 5 | 7 | |
| Outcome for patients receiving 2 induction courses | ||||
| CR | 1 (11%) | 0 (0%) | 1 (6%) | .02 (3 × 2) |
| NR | 5 (56%) | 3 (43%) | 8 (50%) | .22 (2 × 2) |
| Death4-153 | 3 (33%) | 4 (57%) | 7 (44%) | |
| Death within 30 d | 0 | 2 | 2 | |
| Death within 31-67 d4-151 | 3 | 2 | 5 |
| . | ADE (n = 61) . | ADEP (n = 59) . | Total (n = 120) . | P4-150 . |
|---|---|---|---|---|
| Outcome for all patients | ||||
| CR | 28 (46%) | 23 (39%) | 51 (43%) | .008 (3 × 2) |
| NR | 21 (34%) | 10 (17%) | 31 (26%) | .47 (2 × 2) |
| Death | 12 (20%) | 26 (44%) | 38 (32%) | |
| Death within 30 d | 7 | 19 | 26 | |
| Death within 31-67 d4-151 | 5 | 7 | 12 | |
| No. of inductions | ||||
| None‡ | 2 | 0 | 2 | .48 |
| 1 | 50 | 52 | 102 | |
| 2 | 9 | 7 | 16 | |
| Outcome for patients receiving 1 induction course | ||||
| CR | 27 (54%) | 23 (44%) | 50 (49%) | .79 (3 × 2) |
| NR | 14 (28%) | 7 (13%) | 21 (21%) | 1.00 (2 × 2) |
| Death | 9 (18%) | 22 (42%) | 31 (30%) | |
| Death within 30 d | 7 | 17 | 24 | |
| Death within 31-67 d | 2 | 5 | 7 | |
| Outcome for patients receiving 2 induction courses | ||||
| CR | 1 (11%) | 0 (0%) | 1 (6%) | .02 (3 × 2) |
| NR | 5 (56%) | 3 (43%) | 8 (50%) | .22 (2 × 2) |
| Death4-153 | 3 (33%) | 4 (57%) | 7 (44%) | |
| Death within 30 d | 0 | 2 | 2 | |
| Death within 31-67 d4-151 | 3 | 2 | 5 |
The 3 × 2 analysis compares CR, NR, and death, while the 2 × 2 analysis compares CR and no CR (NR plus death).
The last induction death occurred on day 67.
Two patients never started treatment with ADE and are included as nonresponders in the overall comparison based on intent-to-treat.
Deaths occurred within 30 (or 31-67) days from the first day of the initial induction course.