Expression of Th2 and Th1 cytokines in RS cell lines and primary cHL tissues
| Cytokine . | Biologic activity . | Expression by RS cell lines* . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| Th2 cytokines | ||||
| IL-4 | Th2 cell differentiation; B-cell proliferation/survival; Ig class switching to IgG4 and IgE | 2/8 | 2 | |
| IL-13 | B-cell proliferation/survival; Ig class switching to IgG4 and IgE | 4/5 | 93 | Proliferation of HDLM-2 and L-1236 inhibited by anti–IL-13 Ab |
| IL-5 | Eosinophil differentiation, proliferation, and activation | 2/6 | 95 | Associated with tumor eosinophilia |
| IL-6 | Plasma cell differentiation; acute phase reactions; stimulation of IL-1 and TNF-α production | 5/7 | 75 | |
| IL-9 | T-cell and mast cell growth factor | 0/1 | 58 | |
| IL-10 | Immunosuppressive effects | 2/7 | 32 | Associated with EBV+ cases |
| Th1 cytokines | ||||
| IL-12 | Th1 cell differentiation | ND | 85 | Associated with EBV+ cases |
| IL-2 | T-cell growth factor | 0/7 | 22 | |
| IFN-γ | Macrophage differentiation and activation; NK and CD8+ T-cell activation | 2/3 | 47 |
| Cytokine . | Biologic activity . | Expression by RS cell lines* . | Expression in primary cHL tumors (%) . | Comments . |
|---|---|---|---|---|
| Th2 cytokines | ||||
| IL-4 | Th2 cell differentiation; B-cell proliferation/survival; Ig class switching to IgG4 and IgE | 2/8 | 2 | |
| IL-13 | B-cell proliferation/survival; Ig class switching to IgG4 and IgE | 4/5 | 93 | Proliferation of HDLM-2 and L-1236 inhibited by anti–IL-13 Ab |
| IL-5 | Eosinophil differentiation, proliferation, and activation | 2/6 | 95 | Associated with tumor eosinophilia |
| IL-6 | Plasma cell differentiation; acute phase reactions; stimulation of IL-1 and TNF-α production | 5/7 | 75 | |
| IL-9 | T-cell and mast cell growth factor | 0/1 | 58 | |
| IL-10 | Immunosuppressive effects | 2/7 | 32 | Associated with EBV+ cases |
| Th1 cytokines | ||||
| IL-12 | Th1 cell differentiation | ND | 85 | Associated with EBV+ cases |
| IL-2 | T-cell growth factor | 0/7 | 22 | |
| IFN-γ | Macrophage differentiation and activation; NK and CD8+ T-cell activation | 2/3 | 47 |
ND indicates not done.
Expression of cytokines in RS cell lines L-428, KM-H2, HDLM-2, L-1236, L-591, L-540, Co, Ho.