Rescue of scl−/− phenotype by the human SCL YAC
| Transgenic line . | No. of mice . | Human SCLYAC . | scl genotype . | ||
|---|---|---|---|---|---|
| +/+ . | +/− . | −/− . | |||
| 2133 | 104 | − | 7 | 21 | 0 |
| + | 19 | 42 | 15 | ||
| 2054 | 86 | − | 8 | 13 | 0 |
| + | 11 | 35 | 19 | ||
| 2074 | 75 | − | 8 | 12 | 0 |
| + | 11 | 28 | 16 | ||
| Transgenic line . | No. of mice . | Human SCLYAC . | scl genotype . | ||
|---|---|---|---|---|---|
| +/+ . | +/− . | −/− . | |||
| 2133 | 104 | − | 7 | 21 | 0 |
| + | 19 | 42 | 15 | ||
| 2054 | 86 | − | 8 | 13 | 0 |
| + | 11 | 35 | 19 | ||
| 2074 | 75 | − | 8 | 12 | 0 |
| + | 11 | 28 | 16 | ||
Genotypes of offspring resulting from matings between YAC+/−scl+/− parents from 3 transgenic lines. Note that in the presence of the human SCLYAC, all the transgenic lines produce viablescl−/− offspring in the expected mendelian ratios.