Endotoxin, TNFα, and serum chemistry findings in mice with TEL-ABL– and BCR-ABL–induced diseases
| Disease . | Endotoxin (EU/mL) . | TNFα (ng/L) . | Glucose (mmol/L) . | BUN (mmol/L) . | AST (U/L) . | ALT (U/L) . |
|---|---|---|---|---|---|---|
| Healthy Balb/c mouse (n = 2*) | 1.2 ± 0.05 | 0 | 9.55 ± 0.03 | 5 ± 0.7 | 11 ± 2 | 12 ± 5 |
| BCR-ABL CML (n = 2*) | 3.6 | 38 ± 29 | 1.22 | 6.1 | 25 | 6 |
| TEL-ABL SBS (n = 5*) | 50.9 ± 44.7 | 214 ± 108 | < 0.11 | 45.7 ± 5 | 146 ± 38 | 69 ± 22 |
| TEL-ABL CML (n = 4*) | 5.0 ± 1.9 | 36 ± 31 | 2.28 ± 2.05 | 11.1 ± 2.5 | 22 ± 3 | 4 ± 0.4 |
| Disease . | Endotoxin (EU/mL) . | TNFα (ng/L) . | Glucose (mmol/L) . | BUN (mmol/L) . | AST (U/L) . | ALT (U/L) . |
|---|---|---|---|---|---|---|
| Healthy Balb/c mouse (n = 2*) | 1.2 ± 0.05 | 0 | 9.55 ± 0.03 | 5 ± 0.7 | 11 ± 2 | 12 ± 5 |
| BCR-ABL CML (n = 2*) | 3.6 | 38 ± 29 | 1.22 | 6.1 | 25 | 6 |
| TEL-ABL SBS (n = 5*) | 50.9 ± 44.7 | 214 ± 108 | < 0.11 | 45.7 ± 5 | 146 ± 38 | 69 ± 22 |
| TEL-ABL CML (n = 4*) | 5.0 ± 1.9 | 36 ± 31 | 2.28 ± 2.05 | 11.1 ± 2.5 | 22 ± 3 | 4 ± 0.4 |
Values are means ± SE.
TNFα indicates tumor necrosis factor α; BUN, blood urea nitrogen; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CML, chronic myeloid leukemia; and SBS, small-bowel syndrome.
Number of mice analyzed.