Table 6. Effect of HLA allele mismatch... | American Society of Hematology

Table 6.

Effect of HLA allele mismatch on nonrelapse mortality, relapse, and survival in patients with leukemia

HLA mismatch locus^6-150	No. of cases	3-year nonrelapse mortality (%)	P^6-151	3-year relapse rate (%)	P	3-year survival (%)	P
Standard risk
Match	210	27.7	—	12.6	—	65.4	—
A/B	47	54.6	< .001	20.8	.364	39.9	< .001
C	61	28.2	.672	11.0	.707	68.9	.969
DR/DQ	52	27.5	.953	4.9	.162	70.9	.631
A/B + C	38	43.2	< .001	19.0	.460	51.5	.101
A/B + DR/DQ	14	55.6	.048	22.9	.425	50.0	.092
C + DR/DQ	35	50.8	.022	10.5	.953	50.6	.062
A/B + C + DR/DQ	23	58.8	< .001	15.6	.758	39.1	< .001
High risk
Match	214	38.0	—	40.1	—	43.1	—
A/B	44	61.9	< .001	49.2	.632	23.9	.002
C	62	49.8	.077	34.4	.518	36.1	.225
DR/DQ	64	42.4	.578	39.3	.880	35.5	.362
A/B + C	64	64.1	< .001	37.7	.767	21.2	< .001
A/B + DR/DQ	30	71.1	.048	24.9	.329	32.6	.145
C + DR/DQ	35	61.8	.006	32.5	.874	25.7	.018
A/B + C + DR/DQ	31	78.0	.001	27.5	.952	15.9	.003

HLA mismatch locus^6-150	No. of cases	3-year nonrelapse mortality (%)	P^6-151	3-year relapse rate (%)	P	3-year survival (%)	P
Standard risk
Match	210	27.7	—	12.6	—	65.4	—
A/B	47	54.6	< .001	20.8	.364	39.9	< .001
C	61	28.2	.672	11.0	.707	68.9	.969
DR/DQ	52	27.5	.953	4.9	.162	70.9	.631
A/B + C	38	43.2	< .001	19.0	.460	51.5	.101
A/B + DR/DQ	14	55.6	.048	22.9	.425	50.0	.092
C + DR/DQ	35	50.8	.022	10.5	.953	50.6	.062
A/B + C + DR/DQ	23	58.8	< .001	15.6	.758	39.1	< .001
High risk
Match	214	38.0	—	40.1	—	43.1	—
A/B	44	61.9	< .001	49.2	.632	23.9	.002
C	62	49.8	.077	34.4	.518	36.1	.225
DR/DQ	64	42.4	.578	39.3	.880	35.5	.362
A/B + C	64	64.1	< .001	37.7	.767	21.2	< .001
A/B + DR/DQ	30	71.1	.048	24.9	.329	32.6	.145
C + DR/DQ	35	61.8	.006	32.5	.874	25.7	.018
A/B + C + DR/DQ	31	78.0	.001	27.5	.952	15.9	.003

Graft-versus-host disease vector and/or rejection vector.

P value compared with HLA matched cases by univariate analyses.