Table 3.

Examples of possible future CD specificities

MoleculeMolecule sizeCell typesCommentsReference(s)
Identified following antibody production     
 AM-3K antigen 70 & 120 kd Macrophages —  4  
 BDCA-2, BDCA-3, & BDCA-4 antigens ND Dendritic cells Identifies subsets of dendritic cells 5  
 BENE 17 kd Endothelium “Raft-associated” member of MAL family; interacts with caveolin-1 6  
 CMRF-44 ND Dendritic cells Differentiation/activation marker 7, 8  
 CMRF-56 95 kd Dendritic cells Differentiation/activation marker 7, 8  
 H47 antigen 100 kd3-150(120 kd) T cells & most NK cells, B cells, and monocytes Involved in T cell activation? 9  
 Hal-1 200 kd3-150 (100 kd) T cells, EBV-transformed B-cells, myelomonocytic cells, anaplastic large cell lymphoma New lymphoma marker? 10  
 LAK1 antigen 120 kd LGL and LAK cells —  11  
 LAK2 antigen 110 + 140 kd LGL and LAK cells —  11  
 NKp80 80 kd dimer NK cells and CD56-positive T cells Novel member of the killer cell lectinlike receptor gene family, encoded by KLRF1 gene; triggers NK cell cytotoxicity 12, 13  
 VAP-13-151 90 kd Endothelium Mediates lymphocyte-endothelial adhesion; has monoamine oxidase activity 14, 15  
 Wue-1 antigen 94 kd Plasma cells Stimulates growth of plasma cells 16  
Identified via gene cloning     
 BCMA3-152 184 aa B cells TNFR family member; receptor for TALL-1 and APRIL 17, 18  
 B7-H2 302 aa Dendritic cells New member of B7 family; binds ICOS on activated T cells 19  
 CLEC-1 280 aa Dendritic cells Novel C-type lectin-like receptor with cytoplasmic tyrosine-based motif 20  
 CMRF-35A 224 aa NK cells, neutrophils, monocytes, dendritic cells and subset of T lymphocytes Novel Ig superfamily receptors; CMRF-35H contains 3 cytoplasmic tyrosine based motifs 21, 22  
 CMRF-35H 300 aa NK cells, neutrophils, monocytes, dendritic cells and subset of T lymphocytes Novel Ig superfamily receptors; CMRF-35H contains 3 cytoplasmic tyrosine based motifs 21,22  
 CS1 ND NK cells Novel receptor belonging to CD2 subset of Ig superfamily 23  
 DC-STAMP 470 aa Dendritic cells Novel protein containing 7 putative transmembrane domains 24  
 EMR3 652 aa Mainly leucocyte restricted. Highest levels on neutrophils, monocytes and macrophages Novel EGF-TM7 molecule; interacts with a surface ligand on myeloid cells 25  
 Flt-1 (VEGFR-1) ND Endothelial cells, monocytes —  26  
 GPRv53 390 aa Leukocytes G-protein-coupled histamine receptor 27  
 IRTA1, IRTA2 ND Subpopulations of B cells Homologous to the Fc and inhibitory receptor families 28  
 M160 1453 aa Macrophages New member of scavenger receptor cysteine-rich superfamily 29  
 MARCO3-153 520 aa Macrophages Class A scavenger receptor; involved in bacterial clearance in vivo 30, 31  
 TACI 293 aa B cells TNFR family member; receptor for TALL-1 and APRIL 32  
 TREM-13-155 ND Neutrophils and subset of monocytes Novel Ig superfamily receptor; triggers neutrophil secretion (eg, IL-8) and degranulation; associates with DAP12 33, 34  
 TREM-23-155 ND Neutrophils and subset of macrophages Novel Ig superfamily receptor; activates macrophages; associates with DAP12 33, 34  
MoleculeMolecule sizeCell typesCommentsReference(s)
Identified following antibody production     
 AM-3K antigen 70 & 120 kd Macrophages —  4  
 BDCA-2, BDCA-3, & BDCA-4 antigens ND Dendritic cells Identifies subsets of dendritic cells 5  
 BENE 17 kd Endothelium “Raft-associated” member of MAL family; interacts with caveolin-1 6  
 CMRF-44 ND Dendritic cells Differentiation/activation marker 7, 8  
 CMRF-56 95 kd Dendritic cells Differentiation/activation marker 7, 8  
 H47 antigen 100 kd3-150(120 kd) T cells & most NK cells, B cells, and monocytes Involved in T cell activation? 9  
 Hal-1 200 kd3-150 (100 kd) T cells, EBV-transformed B-cells, myelomonocytic cells, anaplastic large cell lymphoma New lymphoma marker? 10  
 LAK1 antigen 120 kd LGL and LAK cells —  11  
 LAK2 antigen 110 + 140 kd LGL and LAK cells —  11  
 NKp80 80 kd dimer NK cells and CD56-positive T cells Novel member of the killer cell lectinlike receptor gene family, encoded by KLRF1 gene; triggers NK cell cytotoxicity 12, 13  
 VAP-13-151 90 kd Endothelium Mediates lymphocyte-endothelial adhesion; has monoamine oxidase activity 14, 15  
 Wue-1 antigen 94 kd Plasma cells Stimulates growth of plasma cells 16  
Identified via gene cloning     
 BCMA3-152 184 aa B cells TNFR family member; receptor for TALL-1 and APRIL 17, 18  
 B7-H2 302 aa Dendritic cells New member of B7 family; binds ICOS on activated T cells 19  
 CLEC-1 280 aa Dendritic cells Novel C-type lectin-like receptor with cytoplasmic tyrosine-based motif 20  
 CMRF-35A 224 aa NK cells, neutrophils, monocytes, dendritic cells and subset of T lymphocytes Novel Ig superfamily receptors; CMRF-35H contains 3 cytoplasmic tyrosine based motifs 21, 22  
 CMRF-35H 300 aa NK cells, neutrophils, monocytes, dendritic cells and subset of T lymphocytes Novel Ig superfamily receptors; CMRF-35H contains 3 cytoplasmic tyrosine based motifs 21,22  
 CS1 ND NK cells Novel receptor belonging to CD2 subset of Ig superfamily 23  
 DC-STAMP 470 aa Dendritic cells Novel protein containing 7 putative transmembrane domains 24  
 EMR3 652 aa Mainly leucocyte restricted. Highest levels on neutrophils, monocytes and macrophages Novel EGF-TM7 molecule; interacts with a surface ligand on myeloid cells 25  
 Flt-1 (VEGFR-1) ND Endothelial cells, monocytes —  26  
 GPRv53 390 aa Leukocytes G-protein-coupled histamine receptor 27  
 IRTA1, IRTA2 ND Subpopulations of B cells Homologous to the Fc and inhibitory receptor families 28  
 M160 1453 aa Macrophages New member of scavenger receptor cysteine-rich superfamily 29  
 MARCO3-153 520 aa Macrophages Class A scavenger receptor; involved in bacterial clearance in vivo 30, 31  
 TACI 293 aa B cells TNFR family member; receptor for TALL-1 and APRIL 32  
 TREM-13-155 ND Neutrophils and subset of monocytes Novel Ig superfamily receptor; triggers neutrophil secretion (eg, IL-8) and degranulation; associates with DAP12 33, 34  
 TREM-23-155 ND Neutrophils and subset of macrophages Novel Ig superfamily receptor; activates macrophages; associates with DAP12 33, 34  

ND indicates not determined.

F3-150

The nonreduced size; reduced size given in parentheses.

F3-151

Vascular adhesion protein.

F3-152

B cell maturation factor.

F3-153

Macrophage receptor with collagenous structure.

F3-155

Triggering receptor expressed on myeloid cells.

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