Table 2. Summary of CASP10 mutations... | American Society of Hematology

Table 2.

Summary of CASP10 mutations identified in NHL

Case no.	Histologic type	LOH^* analysis		SSCP patterns at mutation sites^†	Mutation site	Mutation domain^‡	Nucleotide change^2-153 (predicted amino acid change)
Case no.	Histologic type	117	1337	SSCP patterns at mutation sites^†	Mutation site	Mutation domain^‡	Nucleotide change^2-153 (predicted amino acid change)
2	Peripheral T-cell lymphoma	NI	NI	M + W	Exon 9	p17	1241C>T (Ala414Val)
5	B-cell small lymphocytic lymphoma	NI	NI	M + W	Exon 2	DED	70C>A (Leu24Ile)
7	Angiocentric lymphoma	NI	NI	M + W	Exon 7	p17	740G>A (Gly247Asp)
10	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 2	Between DED/DED	334G>A (Val112Ile)
16	Angiocentric lymphoma	HET	NI	M	Exon 9	p17	1241C>T (Ala414Val)
18	Follicular center cell lymphoma	NI	NI	M + W	Exon 10	p12	1471G>T (Val491Leu)
32	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p12	1334G>A (Gly445Asp)
35	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 7	p17	769C>T (Gln257Stop)
41	Peripheral T-cell lymphoma	NI	NI	M + W	Exon 9	p17	1241C>T (Ala414Val)
51	B-cell small lymphocytic lymphoma	NI	NI	M	Exon 9	p17	1241C>T (Ala414Val)
100	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1241C>T (Ala414Val)
101	MALT lymphoma	NI	NI	M + W	Exon 2	Between DED/DED	332G>C (Arg111Thr)
103	MALT lymphoma	NI	NI	M + W	Exon 9	p17	1042insA (frameshift termination at position 367)
104	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1228G>A (Val410Ile)
105	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p12	1315G>T (Gly436Cys)
106	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1164insG (frameshift termination at position 389)
107	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1163G>T (Arg388Ile)

Case no.	Histologic type	LOH^* analysis		SSCP patterns at mutation sites^†	Mutation site	Mutation domain^‡	Nucleotide change^2-153 (predicted amino acid change)
Case no.	Histologic type	117	1337	SSCP patterns at mutation sites^†	Mutation site	Mutation domain^‡	Nucleotide change^2-153 (predicted amino acid change)
2	Peripheral T-cell lymphoma	NI	NI	M + W	Exon 9	p17	1241C>T (Ala414Val)
5	B-cell small lymphocytic lymphoma	NI	NI	M + W	Exon 2	DED	70C>A (Leu24Ile)
7	Angiocentric lymphoma	NI	NI	M + W	Exon 7	p17	740G>A (Gly247Asp)
10	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 2	Between DED/DED	334G>A (Val112Ile)
16	Angiocentric lymphoma	HET	NI	M	Exon 9	p17	1241C>T (Ala414Val)
18	Follicular center cell lymphoma	NI	NI	M + W	Exon 10	p12	1471G>T (Val491Leu)
32	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p12	1334G>A (Gly445Asp)
35	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 7	p17	769C>T (Gln257Stop)
41	Peripheral T-cell lymphoma	NI	NI	M + W	Exon 9	p17	1241C>T (Ala414Val)
51	B-cell small lymphocytic lymphoma	NI	NI	M	Exon 9	p17	1241C>T (Ala414Val)
100	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1241C>T (Ala414Val)
101	MALT lymphoma	NI	NI	M + W	Exon 2	Between DED/DED	332G>C (Arg111Thr)
103	MALT lymphoma	NI	NI	M + W	Exon 9	p17	1042insA (frameshift termination at position 367)
104	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1228G>A (Val410Ile)
105	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p12	1315G>T (Gly436Cys)
106	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1164insG (frameshift termination at position 389)
107	Diffuse large B-cell lymphoma	NI	NI	M + W	Exon 9	p17	1163G>T (Arg388Ile)

NI indicates not informative (homozygosity); HET, retention heterozygosity.

177 indicates the polymorphism at nucleotide 177 ofCASP10; 1337, the polymorphism at nucleotide at 1337 ofCASP10.

M is aberrant bands of mutant allele without those of wild-type allele; M + W, aberrant bands of mutant allele with those of wild-type allele.

Cleavage site (p17/p12) is cleavage site between p17 large subunit and p12 small subunit; p17, p17 large subunit; p12, p12 small subunit.

Numbering of cDNA of CASP10 was done with respect to the ATG start codon according to Ng et al.21