Pretreatment clinical parameters in 23 patients with myelofibrosis with myeloid metaplasia
| . | Sex . | Age (y) . | Dx-Rx (mo) . | Dupriez score . | Hemoglobin (g/dL) . | WBC (× 109/L) . | ANC (× 109/L) . | Platelet (× 109/L) . | Spleen (cm) . | Cytogenetics . | Cx symptoms . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 69 | 30 | 2 | 0 | 2.2 | 1.8 | 109 | 20 | +9, t(1;9) | Yes |
| 2 | M | 73 | 18 | 1 | 9.5 | 12 | 9 | 436 | 0 | 13q− | No |
| 3 | M | 41 | 22 | 1 | 0 | 28.7 | 21.8 | 129 | 25 | t(1;6) | Yes |
| 4 | M | 62 | 72 | 0 | 10.3 | 17.2 | 8.8 | 246 | 4 | NN | No |
| 5 | F | 67 | 49 | 2 | 9.8 | 2.6 | 1.7 | 149 | 1 | Add(1q−), −14 | No |
| 6 | M | 76 | 8 | 1 | 9.9 | 4.7 | 3.7 | 121 | 6 | NN | No |
| 7 | M | 62 | 12 | 0 | 12.9 | 14.9 | 12.1 | 329 | 20 | Structural* | Yes |
| 8 | M | 42 | 53 | 0 | 10.7 | 6.1 | 2 | 179 | 18 | NN | No |
| 9 | M | 66 | 45 | 2 | 9.3 | 2.3 | 1.1 | 197 | 13 | NA | No |
| 10 | F | 70 | 154 | 1 | 9.4 | 4.4 | 1.9 | 247 | 7 | 13q− | No |
| 11 | M | 73 | 50 | 2 | 0 | 1.8 | 1.3 | 52 | 19 | 20q− | Yes |
| 12 | F | 51 | 18 | 1 | 8.3 | 28.6 | 19.1 | 848 | 25 | 6p− | Yes |
| 13 | M | 63 | 60 | 1 | 0 | 11.9 | 5.8 | 139 | 21 | + 21 | Yes |
| 14 | M | 66 | 5 | 2 | 0 | 2.3 | 1.4 | 165 | 9 | t(3;4) | Yes |
| 15 | M | 61 | 5 | 1 | 0 | 18.4 | 10.5 | 242 | 5 | NA | Yes |
| 16 | M | 51 | 65 | 0 | 10 | 5.3 | 3.7 | 223 | 5 | 13q− | Yes |
| 17 | M | 78 | 126 | 2 | 8.8 | 3.8 | 1.6 | 191 | 10 | NA | No |
| 18 | M | 41 | 24 | 0 | 14.6 | 4.3 | 2.9 | 388 | 3 | − 9 | Yes |
| 19 | M | 76 | 25 | 2 | 0 | 32.1 | 15.7 | 78 | 20 | − Y | Yes |
| 20 | M | 37 | 70 | 0 | 10.7 | 4.4 | 2.5 | 343 | 10 | NA | No |
| 21 | M | 51 | 13 | 1 | 0 | 11 | 5.1 | 33 | 0 | NN | No |
| 22 | F | 75 | 26 | 1 | 0 | 6 | 4 | 101 | 6 | + 9 | Yes |
| 23 | M | 60 | 82 | 1 | 10.5 | 75.1 | 44.3 | 162 | 17 | t(1;6) | No |
| . | Sex . | Age (y) . | Dx-Rx (mo) . | Dupriez score . | Hemoglobin (g/dL) . | WBC (× 109/L) . | ANC (× 109/L) . | Platelet (× 109/L) . | Spleen (cm) . | Cytogenetics . | Cx symptoms . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 69 | 30 | 2 | 0 | 2.2 | 1.8 | 109 | 20 | +9, t(1;9) | Yes |
| 2 | M | 73 | 18 | 1 | 9.5 | 12 | 9 | 436 | 0 | 13q− | No |
| 3 | M | 41 | 22 | 1 | 0 | 28.7 | 21.8 | 129 | 25 | t(1;6) | Yes |
| 4 | M | 62 | 72 | 0 | 10.3 | 17.2 | 8.8 | 246 | 4 | NN | No |
| 5 | F | 67 | 49 | 2 | 9.8 | 2.6 | 1.7 | 149 | 1 | Add(1q−), −14 | No |
| 6 | M | 76 | 8 | 1 | 9.9 | 4.7 | 3.7 | 121 | 6 | NN | No |
| 7 | M | 62 | 12 | 0 | 12.9 | 14.9 | 12.1 | 329 | 20 | Structural* | Yes |
| 8 | M | 42 | 53 | 0 | 10.7 | 6.1 | 2 | 179 | 18 | NN | No |
| 9 | M | 66 | 45 | 2 | 9.3 | 2.3 | 1.1 | 197 | 13 | NA | No |
| 10 | F | 70 | 154 | 1 | 9.4 | 4.4 | 1.9 | 247 | 7 | 13q− | No |
| 11 | M | 73 | 50 | 2 | 0 | 1.8 | 1.3 | 52 | 19 | 20q− | Yes |
| 12 | F | 51 | 18 | 1 | 8.3 | 28.6 | 19.1 | 848 | 25 | 6p− | Yes |
| 13 | M | 63 | 60 | 1 | 0 | 11.9 | 5.8 | 139 | 21 | + 21 | Yes |
| 14 | M | 66 | 5 | 2 | 0 | 2.3 | 1.4 | 165 | 9 | t(3;4) | Yes |
| 15 | M | 61 | 5 | 1 | 0 | 18.4 | 10.5 | 242 | 5 | NA | Yes |
| 16 | M | 51 | 65 | 0 | 10 | 5.3 | 3.7 | 223 | 5 | 13q− | Yes |
| 17 | M | 78 | 126 | 2 | 8.8 | 3.8 | 1.6 | 191 | 10 | NA | No |
| 18 | M | 41 | 24 | 0 | 14.6 | 4.3 | 2.9 | 388 | 3 | − 9 | Yes |
| 19 | M | 76 | 25 | 2 | 0 | 32.1 | 15.7 | 78 | 20 | − Y | Yes |
| 20 | M | 37 | 70 | 0 | 10.7 | 4.4 | 2.5 | 343 | 10 | NA | No |
| 21 | M | 51 | 13 | 1 | 0 | 11 | 5.1 | 33 | 0 | NN | No |
| 22 | F | 75 | 26 | 1 | 0 | 6 | 4 | 101 | 6 | + 9 | Yes |
| 23 | M | 60 | 82 | 1 | 10.5 | 75.1 | 44.3 | 162 | 17 | t(1;6) | No |
Dx-Rx denotes interval duration from initial diagnosis.
Dupriez scores: 0 = Hgb ≥ 10 g/dL and WBC ≥ 4 × 109/L but ≤30 × 109/L; 1 = Hgb < 10 g/dL and WBC < 4 × 109/L or >30 × 109/L; 2 = Hgb < 10 g/dL and WBC < 4 × 109/L or >30 × 109/L.
Hemoglobin level of 0 denotes transfusion dependency.
Spleen size denotes palpable spleen below the left costal margin.
Presence of constitutional (Cx) symptoms required grade 2 or greater fatigue, weight loss, night sweats, or musculoskeletal pain.
ANC indicates absolute neutrophil count; NN, normal cytogenetics; NA, not available.
Structural refers to structural anomalies of chromosomes 2 and 8.