Changes in karyotype observed during course of treatment with imatinib mesylate
| Patient no. . | Pretreatment karyotype [no. positive metaphases] . | Karyotypic change during imatinib mesylate treatment (best cytogenetic response) . |
|---|---|---|
| 10 | 46,XX,t(7;8)(q22;q13), t(9;22)(q34;q11) [15]/ 46,XX,t(9;22)(q34;q11) [5]/ 46,XX [1] | Loss of 46,XX,t(7;8)(q22;q13), t(9;22) clone (0/20 cells by 8 mo) with persistent 46,XX, t(9;22)(q34;q11) clone (absent cytogenetic response) |
| 12 | 46,XY,t(22;9)(9;13;1)(q11;q34;q32;q21;q31)[19]/ | Loss of 47,XY,t(22;9)(9;13;1)+ 8 (1 cell only) with persistent 46,XY,t(22;9)(9;1;13) clone |
| 47,XY,t(22;9)(9;13;1)(q11;q34;q32;q21;q31),+ 8 [1] | Addition of 47,XY,+ 8 (1/20 cells at 14 mo) (absent cytogenetic response) | |
| 15 | 46,XY,t(9;22)(q34;q11) [22] | 46,XY, t(9;22)(q34;q11),− 9,+ l(17)(q11) (in 2/10 cells at 14 mo) (partial cytogenetic response) |
| 16 | 46,XX,t(9;22)(q34;q11) [17] | 47,XX,+ 8[5/8 cells at 11 mo;19/20 cells at 14 mo] |
| Persistent 46,XX, t(9;22)(q34;q11) 1/20 (partial cytogenetic response) | ||
| 17 | 46,XX,t(9;22)(q34;q11) [20] | 46,XX,t(9;22)(q34;q11),t(12;12)(q13;q24.3) (4/20 cells at 8 mo; 1/20 cells at 17 mo) (partial cytogenetic response) |
| Patient no. . | Pretreatment karyotype [no. positive metaphases] . | Karyotypic change during imatinib mesylate treatment (best cytogenetic response) . |
|---|---|---|
| 10 | 46,XX,t(7;8)(q22;q13), t(9;22)(q34;q11) [15]/ 46,XX,t(9;22)(q34;q11) [5]/ 46,XX [1] | Loss of 46,XX,t(7;8)(q22;q13), t(9;22) clone (0/20 cells by 8 mo) with persistent 46,XX, t(9;22)(q34;q11) clone (absent cytogenetic response) |
| 12 | 46,XY,t(22;9)(9;13;1)(q11;q34;q32;q21;q31)[19]/ | Loss of 47,XY,t(22;9)(9;13;1)+ 8 (1 cell only) with persistent 46,XY,t(22;9)(9;1;13) clone |
| 47,XY,t(22;9)(9;13;1)(q11;q34;q32;q21;q31),+ 8 [1] | Addition of 47,XY,+ 8 (1/20 cells at 14 mo) (absent cytogenetic response) | |
| 15 | 46,XY,t(9;22)(q34;q11) [22] | 46,XY, t(9;22)(q34;q11),− 9,+ l(17)(q11) (in 2/10 cells at 14 mo) (partial cytogenetic response) |
| 16 | 46,XX,t(9;22)(q34;q11) [17] | 47,XX,+ 8[5/8 cells at 11 mo;19/20 cells at 14 mo] |
| Persistent 46,XX, t(9;22)(q34;q11) 1/20 (partial cytogenetic response) | ||
| 17 | 46,XX,t(9;22)(q34;q11) [20] | 46,XX,t(9;22)(q34;q11),t(12;12)(q13;q24.3) (4/20 cells at 8 mo; 1/20 cells at 17 mo) (partial cytogenetic response) |