Novel TFs identified by database search
| UniGene cluster ID . | Gene name . | Gene description . | Characterization . | Available function/information . | References . |
|---|---|---|---|---|---|
| Hs.2815 | POU6F1 | POU domain, class 6, transcription factor 1 | PC | Member of the class IV POU homeodomain family of transcription factors | Wey E, Schafer BW. Biochem Biophys Res Commun. 1996.22 |
| Hs.239720 | CNOT2 | CCR4-NOT transcription complex, subunit 2 | PC | May function as a transcription factor | Albert TK et al. Nucleic Acids Res. 2000.23 |
| Hs.108106 | ICBP90 | Transcription factor | PC | CCAAT binding protein, may be involved in the regulation of topoisomerase IIα gene expression | Hopfner R et al. Gene. 2001.24 |
| Hs.294101 | PBX3 | Pre–B-cell leukemia transcription factor 3 | PC | Member of the homeodomain family of DNA-binding proteins; very strongly similar to murine Pbx3 | Knoepfler PS, Kamps MP. Mech Dev. 1997.25 |
| Hs.249184 | TCF19 | Transcription factor 19 (SC1) | PC | Putative transcription factor; may be involved in the later stages of cell cycle progression | Teraoka Y et al. Tissue Antigens. 2000.26 |
| Hs.29417 | ZF | HCF-binding transcription factor Zhangfei | PC | Contains a basic domain-leucine zipper (bZIP) region, an acidic activation domain, and a consensus HCF (host cell factor)-binding motif | Lu R, Misra V. Nucleic Acids Res. 2000.27 |
| Hs.155313 | DATF1 | Death-associated transcription factor 1 | PC | Protein has 2 zinc finger motifs, nuclear localization signals, and transcriptional activation domains; may be involved in cell death during development | Garcia-Domingo D et al. Proc Natl Acad Sci U S A. 1999.28 |
| Hs.26703 | CNOT8 | CCR4-NOT transcription complex, subunit 8 | PC | Similar to S cerevisiae transcriptional regulator Pop2p. The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription | Albert TK et al. Nucleic Acids Res. 2000.23 |
| Hs.78061 | TCF21 | Transcription factor 21 | PC | Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis, and may play a role in the specification or differentiation of one or more subsets of epicardial cell types | Robb L et al. Dev Dyn. 1998.29 |
| Hs.59506 | DMRT2 | Doublesex and mab-3 related transcription factor 2 | PC | May be involved in male sexual development; contains a DNA-binding domain | Ottolenghi C et al. Genomics. 2000.30 |
| Hs.21704 | TCF12 | Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) | PC | Expressed in many tissues, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins | Di Rocco G et al. Mol Cell Biol. 1997.31 |
| Hs.226318 | CNOT7 | CCR4-NOT transcription complex, subunit 7 | PC | The protein encoded by this gene binds to an antiproliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation | Prevot D et al. J Biol Chem. 2001.32 |
| Hs.35841 | NFIX | Nuclear factor I/X (CCAAT-binding transcription factor) | PC | The nuclear factor I (NFI) family of transcription/replication proteins is required for the cell type–specific expression of a number of cellular and viral genes. | Fletcher CF et al. Mamm Genome. 1999.33 |
| Hs.100932 | TCF17 | Transcription factor 17 | PC | A human homologue of rat zinc finger gene Kid 1; contains a Kruppel-associated box (KRAB) and C2H2 zinc fingers | Przyborski SA et al. Cancer Res. 1998.34 |
| Hs.92282 | PITX2 | Pairedlike homeodomain transcription factor 2 | PC | May regulate gene expression and control cell differentiation; member of the homeodomain family of DNA binding proteins | Degar BA et al. Exp Hematol. 2001.35 |
| Hs.97624 | HSF2BP | Heat shock transcription factor 2 binding protein | PC | HSF2 binding protein (HSF2BP) associates with HSF2. HSF2BP may therefore be involved in modulating HSF2 activation. | Yoshima T et al. Gene. 1998.36 |
| Hs.20423 | CNOT4 | CCR4-NOT transcription complex, subunit 4 | PC | The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription. | Albert TK et al. Nucleic Acids Res. 2000.23 |
| Hs.2430 | TCFL1 | Transcription factor– like 1 | PC | May function as a transcription factor | Horikawa I et al. Biochem Biophys Res Commun. 1995.37 |
| Hs.30824 | LZTFL1 | Leucine zipper transcription factor– like 1 | N | The LZTFL1 gene has 2 transcript isoforms displaying alternative polyadenylation. | Kiss H et al. Genomics. 2001.38 |
| Hs.27299 | HCNGP | Transcriptional regulator protein | N | Strongly similar to uncharacterized murineHcngp | N/A |
| Hs.93748 | H sapiens cDNA clone moderately similar to transcription factorBTF3 | N | N/A | N/A | |
| Hs.173854 | PAXIP1L | PAX transcription activation domain interacting protein 1 like | N | N/A | N/A |
| Hs.268115 | ESTs, weakly similar to T08599 probable transcription factor CA150 [H sapiens] | N | N/A | N/A | |
| Hs.24572 | ESTs, weakly similar to TC17_human transcription factor 17 [H sapiens] | N | N/A | N/A | |
| Hs.171185 | P38IP | Transcription factor (p38 interacting protein) | N | N/A | N/A |
| UniGene cluster ID . | Gene name . | Gene description . | Characterization . | Available function/information . | References . |
|---|---|---|---|---|---|
| Hs.2815 | POU6F1 | POU domain, class 6, transcription factor 1 | PC | Member of the class IV POU homeodomain family of transcription factors | Wey E, Schafer BW. Biochem Biophys Res Commun. 1996.22 |
| Hs.239720 | CNOT2 | CCR4-NOT transcription complex, subunit 2 | PC | May function as a transcription factor | Albert TK et al. Nucleic Acids Res. 2000.23 |
| Hs.108106 | ICBP90 | Transcription factor | PC | CCAAT binding protein, may be involved in the regulation of topoisomerase IIα gene expression | Hopfner R et al. Gene. 2001.24 |
| Hs.294101 | PBX3 | Pre–B-cell leukemia transcription factor 3 | PC | Member of the homeodomain family of DNA-binding proteins; very strongly similar to murine Pbx3 | Knoepfler PS, Kamps MP. Mech Dev. 1997.25 |
| Hs.249184 | TCF19 | Transcription factor 19 (SC1) | PC | Putative transcription factor; may be involved in the later stages of cell cycle progression | Teraoka Y et al. Tissue Antigens. 2000.26 |
| Hs.29417 | ZF | HCF-binding transcription factor Zhangfei | PC | Contains a basic domain-leucine zipper (bZIP) region, an acidic activation domain, and a consensus HCF (host cell factor)-binding motif | Lu R, Misra V. Nucleic Acids Res. 2000.27 |
| Hs.155313 | DATF1 | Death-associated transcription factor 1 | PC | Protein has 2 zinc finger motifs, nuclear localization signals, and transcriptional activation domains; may be involved in cell death during development | Garcia-Domingo D et al. Proc Natl Acad Sci U S A. 1999.28 |
| Hs.26703 | CNOT8 | CCR4-NOT transcription complex, subunit 8 | PC | Similar to S cerevisiae transcriptional regulator Pop2p. The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription | Albert TK et al. Nucleic Acids Res. 2000.23 |
| Hs.78061 | TCF21 | Transcription factor 21 | PC | Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis, and may play a role in the specification or differentiation of one or more subsets of epicardial cell types | Robb L et al. Dev Dyn. 1998.29 |
| Hs.59506 | DMRT2 | Doublesex and mab-3 related transcription factor 2 | PC | May be involved in male sexual development; contains a DNA-binding domain | Ottolenghi C et al. Genomics. 2000.30 |
| Hs.21704 | TCF12 | Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) | PC | Expressed in many tissues, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins | Di Rocco G et al. Mol Cell Biol. 1997.31 |
| Hs.226318 | CNOT7 | CCR4-NOT transcription complex, subunit 7 | PC | The protein encoded by this gene binds to an antiproliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation | Prevot D et al. J Biol Chem. 2001.32 |
| Hs.35841 | NFIX | Nuclear factor I/X (CCAAT-binding transcription factor) | PC | The nuclear factor I (NFI) family of transcription/replication proteins is required for the cell type–specific expression of a number of cellular and viral genes. | Fletcher CF et al. Mamm Genome. 1999.33 |
| Hs.100932 | TCF17 | Transcription factor 17 | PC | A human homologue of rat zinc finger gene Kid 1; contains a Kruppel-associated box (KRAB) and C2H2 zinc fingers | Przyborski SA et al. Cancer Res. 1998.34 |
| Hs.92282 | PITX2 | Pairedlike homeodomain transcription factor 2 | PC | May regulate gene expression and control cell differentiation; member of the homeodomain family of DNA binding proteins | Degar BA et al. Exp Hematol. 2001.35 |
| Hs.97624 | HSF2BP | Heat shock transcription factor 2 binding protein | PC | HSF2 binding protein (HSF2BP) associates with HSF2. HSF2BP may therefore be involved in modulating HSF2 activation. | Yoshima T et al. Gene. 1998.36 |
| Hs.20423 | CNOT4 | CCR4-NOT transcription complex, subunit 4 | PC | The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription. | Albert TK et al. Nucleic Acids Res. 2000.23 |
| Hs.2430 | TCFL1 | Transcription factor– like 1 | PC | May function as a transcription factor | Horikawa I et al. Biochem Biophys Res Commun. 1995.37 |
| Hs.30824 | LZTFL1 | Leucine zipper transcription factor– like 1 | N | The LZTFL1 gene has 2 transcript isoforms displaying alternative polyadenylation. | Kiss H et al. Genomics. 2001.38 |
| Hs.27299 | HCNGP | Transcriptional regulator protein | N | Strongly similar to uncharacterized murineHcngp | N/A |
| Hs.93748 | H sapiens cDNA clone moderately similar to transcription factorBTF3 | N | N/A | N/A | |
| Hs.173854 | PAXIP1L | PAX transcription activation domain interacting protein 1 like | N | N/A | N/A |
| Hs.268115 | ESTs, weakly similar to T08599 probable transcription factor CA150 [H sapiens] | N | N/A | N/A | |
| Hs.24572 | ESTs, weakly similar to TC17_human transcription factor 17 [H sapiens] | N | N/A | N/A | |
| Hs.171185 | P38IP | Transcription factor (p38 interacting protein) | N | N/A | N/A |
The table presents 25 novel and poorly characterized genes or ESTs resulting from these studies, which are likely to be TFs. The table presents the UniGene cluster identification (ID) number, the gene name, the UniGene description of the sequence, the literature characterization, additional available functional information about the gene, and the literature citation. Characterization based on literature search is described in the text as: W, well characterized; PC, partially characterized; N, novel; N/A, not available.