Kinetic constants of factor IX clearance from circulation of factor IX–deficient mice
| . | K5A . | K5R . | Wild type . |
|---|---|---|---|
| t1/2(hour)* | 3.3 | 7.7 | 6.9 |
| kα(hour)−1 | 4.5 | 10.8 | 5.3 |
| kβ(hour)−1 | 0.21 | 0.09 | 0.10 |
| . | K5A . | K5R . | Wild type . |
|---|---|---|---|
| t1/2(hour)* | 3.3 | 7.7 | 6.9 |
| kα(hour)−1 | 4.5 | 10.8 | 5.3 |
| kβ(hour)−1 | 0.21 | 0.09 | 0.10 |
Constants were determined using the following equation: [factor IX] = Aoe−kαt + Boe−kβt, where kα = rate constant for α phase, kβ = rate constant for β phase, Ao = Y intercept of first exponential, and Bo · = Y intercept of second exponential.
Determined using kβ.
Results are from 3 experiments.