Repair of melphalan-induced interstrand crosslinks in plasma cells and in vitro cytotoxicity to melphalan
| Patient . | Melphalan . | % Repair at 40 h . | IC50 (μM) . |
|---|---|---|---|
| 1 | Naive | 0 | ND |
| 2 | Naive | 0 | 15 |
| 3 | Naive | 0 | ND |
| 4 | Naive | 0 | ND |
| 5 | Naive | 0 | 8 |
| 6 | Naive | 0 | ND |
| 7 | High dose | 100 | ND |
| 8 | High dose | 72 | 55 |
| 9 | High dose | 54 | ND |
| 10 | High dose | 42 | 23 |
| 4 | High dose | 56 | 39 |
| 11 | High dose | 65 | ND |
| 12 | Oral | 48 | 52 |
| Patient . | Melphalan . | % Repair at 40 h . | IC50 (μM) . |
|---|---|---|---|
| 1 | Naive | 0 | ND |
| 2 | Naive | 0 | 15 |
| 3 | Naive | 0 | ND |
| 4 | Naive | 0 | ND |
| 5 | Naive | 0 | 8 |
| 6 | Naive | 0 | ND |
| 7 | High dose | 100 | ND |
| 8 | High dose | 72 | 55 |
| 9 | High dose | 54 | ND |
| 10 | High dose | 42 | 23 |
| 4 | High dose | 56 | 39 |
| 11 | High dose | 65 | ND |
| 12 | Oral | 48 | 52 |
IC50, dose of melphalan giving 50% inhibition of cell growth; ND indicates not determined.