Relapse
| Cohort . | Any cGVHD . | Lim, ext . | Mild, mod, sev . | Low, int, high . | ||||
|---|---|---|---|---|---|---|---|---|
| RR5-150 . | 95% CI . | RR5-150 . | 95% CI . | RR5-150 . | 95% CI . | RR5-150 . | 95% CI . | |
| IBMTR-1 | 0.55-152 | (0.3-0.7) | 0.5 | (0.3-0.8) | 0.5 | (0.3-0.7) | 0.5 | (0.3-0.8) |
| 0.4 | (0.3-0.7) | 0.3 | (0.2-0.6) | 0.4 | (0.2-0.7) | |||
| 0.7 | (0.4-1.5) | 0.4 | (0.2-0.9) | |||||
| IBMTR-2 | 0.65-151 | (0.4-0.9) | 0.85-153 | (0.5-1.4) | 0.6 | (0.4-1.1) | 0.5 | (0.3-0.9) |
| 0.3 | (0.2-0.7) | 0.6 | (0.3-1.1) | 1.0 | (0.5-1.9) | |||
| 0.3 | (0.1-1.4) | 0.3 | (0.1-1.0) | |||||
| NMDP | 0.65-151 | (0.3-1.0) | 0.5 | (0.2-1.1) | N/A | 0.4 | (0.2-1.2) | |
| 0.6 | (0.3-1.1) | 0.7 | (0.3-1.5) | |||||
| 1.0 | (0.3-2.9) | |||||||
| Cohort . | Any cGVHD . | Lim, ext . | Mild, mod, sev . | Low, int, high . | ||||
|---|---|---|---|---|---|---|---|---|
| RR5-150 . | 95% CI . | RR5-150 . | 95% CI . | RR5-150 . | 95% CI . | RR5-150 . | 95% CI . | |
| IBMTR-1 | 0.55-152 | (0.3-0.7) | 0.5 | (0.3-0.8) | 0.5 | (0.3-0.7) | 0.5 | (0.3-0.8) |
| 0.4 | (0.3-0.7) | 0.3 | (0.2-0.6) | 0.4 | (0.2-0.7) | |||
| 0.7 | (0.4-1.5) | 0.4 | (0.2-0.9) | |||||
| IBMTR-2 | 0.65-151 | (0.4-0.9) | 0.85-153 | (0.5-1.4) | 0.6 | (0.4-1.1) | 0.5 | (0.3-0.9) |
| 0.3 | (0.2-0.7) | 0.6 | (0.3-1.1) | 1.0 | (0.5-1.9) | |||
| 0.3 | (0.1-1.4) | 0.3 | (0.1-1.0) | |||||
| NMDP | 0.65-151 | (0.3-1.0) | 0.5 | (0.2-1.1) | N/A | 0.4 | (0.2-1.2) | |
| 0.6 | (0.3-1.1) | 0.7 | (0.3-1.5) | |||||
| 1.0 | (0.3-2.9) | |||||||
For abbreviations see Table 3.
Adjusted for disease type (acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia), disease stage (early, intermediate, advanced), age (years), patient-donor sex matching, and presence of prior acute GVHD (yes, no).
P ≤ .01 compared with no cGVHD.
P ≤ .0001 compared with no cGVHD.
P ≤ .01 compared with the next most severe category.