Table 3. Adverse prognostic factors in... | American Society of Hematology

Table 3.

Adverse prognostic factors in Cox proportional hazards model

Feature	Day 15			Days 22-25
Feature	Hazard ratio^3-150	95% CI	P	Hazard ratio^3-150	95% CI	P
At least 1% lymphoblasts	3.14	(2.06, 4.79)	< .001	9.83	(6.12, 15.79)	< .001
CNS status at diagnosis	1.88	(1.26, 2.81)	.002	2.34	(1.54, 3.24)	< .001
DI	1.85	(1.03, 3.32)	.040	1.56	(0.91, 2.67)	.11
Age at diagnosis, y	1.13	(0.63, 2.04)	.68	1.05	(0.66, 1.66)	.84
WBC at diagnosis	0.95	(0.55, 1.64)	.85	1.21	(0.76, 1.93)	.42
Lineage	0.99	(0.60, 1.62)	.96	1.15	(0.75, 1.75)	.53
NCI/Rome risk criteria	1.42	(0.71, 2.85)	.32	1.52	(0.83, 2.79)	.17

Feature	Day 15			Days 22-25
Feature	Hazard ratio^3-150	95% CI	P	Hazard ratio^3-150	95% CI	P
At least 1% lymphoblasts	3.14	(2.06, 4.79)	< .001	9.83	(6.12, 15.79)	< .001
CNS status at diagnosis	1.88	(1.26, 2.81)	.002	2.34	(1.54, 3.24)	< .001
DI	1.85	(1.03, 3.32)	.040	1.56	(0.91, 2.67)	.11
Age at diagnosis, y	1.13	(0.63, 2.04)	.68	1.05	(0.66, 1.66)	.84
WBC at diagnosis	0.95	(0.55, 1.64)	.85	1.21	(0.76, 1.93)	.42
Lineage	0.99	(0.60, 1.62)	.96	1.15	(0.75, 1.75)	.53
NCI/Rome risk criteria	1.42	(0.71, 2.85)	.32	1.52	(0.83, 2.79)	.17

Stratifying for treatment protocol and simultaneously adjusting for age, WBC, NCI/Rome risk criteria, lineage, DI, and CNS status at diagnosis.