Table 1. Protein components of the assay... | American Society of Hematology

Table 1.

Protein components of the assay systems

Protein	Concentration, μg/mL	Concentration, molar
Prothrombin	100 μg/mL	1400 nM
Factor V	7 μg/mL	20 nM
Factor VIII^*	0.1 μg/mL	0.3 nM
Factor IX	4 μg/mL	70 nM
Factor X	8 μg/mL	135 nM
Factor XI	5 μg/mL	25 nM
Antithrombin III	180 μg/mL	3000 nM
Tissue factor pathway inhibitor	0.1 μg/mL	3 nM
Activated protein C	Varied	Varied
Protein S^†	8 μg/mL	100 nM
Factor VIIa		0.2 nM
Tissue factor
From monocytes	—	1 pM
From endothelial cells	—	< 1 pM
From lipid experiments	—	100 pM or 10 pM

Protein	Concentration, μg/mL	Concentration, molar
Prothrombin	100 μg/mL	1400 nM
Factor V	7 μg/mL	20 nM
Factor VIII^*	0.1 μg/mL	0.3 nM
Factor IX	4 μg/mL	70 nM
Factor X	8 μg/mL	135 nM
Factor XI	5 μg/mL	25 nM
Antithrombin III	180 μg/mL	3000 nM
Tissue factor pathway inhibitor	0.1 μg/mL	3 nM
Activated protein C	Varied	Varied
Protein S^†	8 μg/mL	100 nM
Factor VIIa		0.2 nM
Tissue factor
From monocytes	—	1 pM
From endothelial cells	—	< 1 pM
From lipid experiments	—	100 pM or 10 pM

Factor VIII is associated with von Willebrand factor.

†

The protein S concentration approximates the plasma concentration that is free (ie, not bound to C4B binding protein). No C4B binding protein is added to the reactions.

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