Table 2. Features prior to DLI and ICD... | American Society of Hematology

Table 2.

Features prior to DLI and ICD

Features	ICD^*					P^2-155
	Total n = 344	Group A^† n = 98	Group B^‡ n = 107	Group C^2-153 n = 93	Not available n = 46
	%	%	%	%	%
Patient age
Younger than 40 y	54	61	45	53	61	.22
40 y and older	46	39	55	47	39
Donor type
SIB	79	70	79	90	72	<.01
VUD	21	30	21	10	28
Sex of donor
Male	67	73	56	69	72	.53
Female	33	27	44	31	28
Sex match with the donor
Matched	55	62	41	59	65	.71
Mismatched	45	38	59	41	35
Phase at SCT
First chronic phase	79	84	79	77	74	.28
More advanced	21	16	21	23	26
T-cell depletion at SCT
No	58	38	53	75	82	<.01
Yes	42	62	47	25	18
Interval SCT-first infusion
Fewer than 2 y	44	46	47	39	45	.32
More than 2 y	56	54	53	61	55
Acute GVHD after SCT
Grade 0	44	33	46	51	53	.03
Grade I	30	36	27	29	22
Grades II-IV	26	32	27	20	25
Chronic GVHD after SCT
None	69	64	70	73	67	.31
Limited	22	28	20	19	23
Extensive	9	8	10	7	9
GVHD after SCT
None	38	25	40	42	51	.04
Grade I and/or limited	32	38	31	33	20
Grade higher than I and/or extensive	30	37	29	25	29
Stage of relapse at DLI
Molecular/cytogenetic	30	42	32	19	24	<.01
Hematologic	52	49	47	60	52
Transformed	18	9	21	21	24
Date of DLI
1988-1995	53	26	55	80	57	<.01
1996-1998	47	74	45	20	43

Features	ICD^*					P^2-155
	Total n = 344	Group A^† n = 98	Group B^‡ n = 107	Group C^2-153 n = 93	Not available n = 46
	%	%	%	%	%
Patient age
Younger than 40 y	54	61	45	53	61	.22
40 y and older	46	39	55	47	39
Donor type
SIB	79	70	79	90	72	<.01
VUD	21	30	21	10	28
Sex of donor
Male	67	73	56	69	72	.53
Female	33	27	44	31	28
Sex match with the donor
Matched	55	62	41	59	65	.71
Mismatched	45	38	59	41	35
Phase at SCT
First chronic phase	79	84	79	77	74	.28
More advanced	21	16	21	23	26
T-cell depletion at SCT
No	58	38	53	75	82	<.01
Yes	42	62	47	25	18
Interval SCT-first infusion
Fewer than 2 y	44	46	47	39	45	.32
More than 2 y	56	54	53	61	55
Acute GVHD after SCT
Grade 0	44	33	46	51	53	.03
Grade I	30	36	27	29	22
Grades II-IV	26	32	27	20	25
Chronic GVHD after SCT
None	69	64	70	73	67	.31
Limited	22	28	20	19	23
Extensive	9	8	10	7	9
GVHD after SCT
None	38	25	40	42	51	.04
Grade I and/or limited	32	38	31	33	20
Grade higher than I and/or extensive	30	37	29	25	29
Stage of relapse at DLI
Molecular/cytogenetic	30	42	32	19	24	<.01
Hematologic	52	49	47	60	52
Transformed	18	9	21	21	24
Date of DLI
1988-1995	53	26	55	80	57	<.01
1996-1998	47	74	45	20	43

SIB indicates sibling donor.

Definition in “Patients and methods.”

Patients with initial cell dose <0.21 MNC × 10⁸/kg.

Patients with initial cell dose from 0.21 to 2.0 MNC × 10⁸/kg.

Patients with initial cell dose >2.0 MNC × 10⁸/kg.

Comparing different features in ICD groups A, B, and C.