Cytogenetic analysis of murine leukemias initiated by PML-RARA
| Mouse . | Tissue . | Karyotype . |
|---|---|---|
| PML-RARAmice | ||
| 1111 | BM/spleen | 42,XX,+8,+15[7]/40,XX[2] |
| 909 | Spleen | 39,X,−Y,del(2)(C3H1)[4]/40,idem,+8[2]/40,idem,+16[2]/NCA:41,idem,+8,+16[1]/41,idem,+6,+8[1] |
| 935 | Spleen/LN | 39,X,−Y[7]/40,idem,+16[2]/NCA:40,idem,+15[1]/40,idem,+X[1] |
| 1333 | Spleen | 42,X,−Y,+8,+15,+16[6]/41,idem,−13[3]/NCA:42,idem,+X,−13[1] |
| 1717 | BM/spleen | 44,XY,+8[11],+10[10],+15[8],+17[7][cp11] |
| 1718 | BM/LN | 41,XY,+15[5]/NCA:40,X,+X,−Y[1]/40,XY[4] |
| 1950 | Spleen | 41,XY,+15[9]/40,XY[2] |
| 42 | Spleen | 40,XY[15] |
| 3509 | Spleen | 42,X,−Y,+10,+14,+15[10] |
| 802 | Spleen | 42,X,−X,+6,+7,+14[cp5]/40,XX[4] |
| 1097.1 | Spleen | 50,X,−Y,+1,+4,+8,+10,+12,+14,+15,+der(15)t(14;15)(D3;D1 or D2),+16,+17,+18[10] |
| PML-RARA/BCL2mice | ||
| 2995A4 | Spleen | 41,X,−X,+8,+15[9]/NCA:41,X,−X,−5,+8,−9,+15,+18,+19[1] |
| 1712 | BM | 49,X,−Y,+4,+6,+7,+8,+10,+11,+13,+14,+15,+16[cp5]/40,XY[4] |
| 1713 | Spleen | 42,X,−Y,i(7q),+8,+10,+15[8]/43,idem,+4[2] |
| 65 | Spleen | 45,X,−X,+4,+7,+10,+14,+15,+15[cp11] |
| 66 | Spleen | 45,X,−X,+6,+7,+8,+10,+14,+15[3]/59,X,−X,+1,+4,+5,+6,+7,+8,+9,+10,+10,+11,+11, +12,+13,+15,+15,+16,+17,+18,+18,+19[7]/40,XX[1] |
| 67 | Spleen | 46,XY,+4,+6,+7,+12,+15,+18[6]/47,idem,+16[3] |
| 70 | Spleen | 45,XY,+4,+7,+10,+14,+15[10]/40,XY[1] |
| 1711 | Spleen | 50,XX,+1,+4,+6,+7,+8,+10,+11,+14,+15,+18[1]/49,idem,−X[7]/NCA:49,idem, −X,−X,del(6)(D1F3),+12[1]/40,XX[1] |
| Mouse . | Tissue . | Karyotype . |
|---|---|---|
| PML-RARAmice | ||
| 1111 | BM/spleen | 42,XX,+8,+15[7]/40,XX[2] |
| 909 | Spleen | 39,X,−Y,del(2)(C3H1)[4]/40,idem,+8[2]/40,idem,+16[2]/NCA:41,idem,+8,+16[1]/41,idem,+6,+8[1] |
| 935 | Spleen/LN | 39,X,−Y[7]/40,idem,+16[2]/NCA:40,idem,+15[1]/40,idem,+X[1] |
| 1333 | Spleen | 42,X,−Y,+8,+15,+16[6]/41,idem,−13[3]/NCA:42,idem,+X,−13[1] |
| 1717 | BM/spleen | 44,XY,+8[11],+10[10],+15[8],+17[7][cp11] |
| 1718 | BM/LN | 41,XY,+15[5]/NCA:40,X,+X,−Y[1]/40,XY[4] |
| 1950 | Spleen | 41,XY,+15[9]/40,XY[2] |
| 42 | Spleen | 40,XY[15] |
| 3509 | Spleen | 42,X,−Y,+10,+14,+15[10] |
| 802 | Spleen | 42,X,−X,+6,+7,+14[cp5]/40,XX[4] |
| 1097.1 | Spleen | 50,X,−Y,+1,+4,+8,+10,+12,+14,+15,+der(15)t(14;15)(D3;D1 or D2),+16,+17,+18[10] |
| PML-RARA/BCL2mice | ||
| 2995A4 | Spleen | 41,X,−X,+8,+15[9]/NCA:41,X,−X,−5,+8,−9,+15,+18,+19[1] |
| 1712 | BM | 49,X,−Y,+4,+6,+7,+8,+10,+11,+13,+14,+15,+16[cp5]/40,XY[4] |
| 1713 | Spleen | 42,X,−Y,i(7q),+8,+10,+15[8]/43,idem,+4[2] |
| 65 | Spleen | 45,X,−X,+4,+7,+10,+14,+15,+15[cp11] |
| 66 | Spleen | 45,X,−X,+6,+7,+8,+10,+14,+15[3]/59,X,−X,+1,+4,+5,+6,+7,+8,+9,+10,+10,+11,+11, +12,+13,+15,+15,+16,+17,+18,+18,+19[7]/40,XX[1] |
| 67 | Spleen | 46,XY,+4,+6,+7,+12,+15,+18[6]/47,idem,+16[3] |
| 70 | Spleen | 45,XY,+4,+7,+10,+14,+15[10]/40,XY[1] |
| 1711 | Spleen | 50,XX,+1,+4,+6,+7,+8,+10,+11,+14,+15,+18[1]/49,idem,−X[7]/NCA:49,idem, −X,−X,del(6)(D1F3),+12[1]/40,XX[1] |
BM indicates bone marrow; LN, lymph node; NCA, nonclonal abnormal cell.