Effect of photodynamic cell purging process on graft-versus-leukemia effect
| Groups . | n . | % BCL1 cells in peripheral blood . | Mean ± SD . |
|---|---|---|---|
| Normal C57BL/6 | 9 | 1.5, 0.6, 0.7, 0.4, 0.3, 1.0, 1.6, 1.0, 1.3 | 0.9 ± 0.5 |
| Normal BALB/c | 5 | 1.6, 0.8, 0.4, 0.4, 0.4 | 0.7 ± 0.5 |
| BCL1 + TCD BMCs only | 7 | 9.9, 8.6, 12.5, 39.5, 13.8, 6.4, 1.8 | 13.2 ± 12.3* |
| Untreated primed cells | 7 | 0.2, 0.2, 0.5, 0.5, 0.9, 1.7, 0.5 | 0.6 ± 0.5† |
| PDP-treated primed cells (20 μM) | 10 | 0.3, 0.2, 0.2, 0.2, 0.6, 0.4, 0.5, 0.7, 0.4 | 0.4 ± 0.2† |
| Groups . | n . | % BCL1 cells in peripheral blood . | Mean ± SD . |
|---|---|---|---|
| Normal C57BL/6 | 9 | 1.5, 0.6, 0.7, 0.4, 0.3, 1.0, 1.6, 1.0, 1.3 | 0.9 ± 0.5 |
| Normal BALB/c | 5 | 1.6, 0.8, 0.4, 0.4, 0.4 | 0.7 ± 0.5 |
| BCL1 + TCD BMCs only | 7 | 9.9, 8.6, 12.5, 39.5, 13.8, 6.4, 1.8 | 13.2 ± 12.3* |
| Untreated primed cells | 7 | 0.2, 0.2, 0.5, 0.5, 0.9, 1.7, 0.5 | 0.6 ± 0.5† |
| PDP-treated primed cells (20 μM) | 10 | 0.3, 0.2, 0.2, 0.2, 0.6, 0.4, 0.5, 0.7, 0.4 | 0.4 ± 0.2† |
Peripheral blood was obtained from recipients 30 days after bone marrow transplantation. Percentages of BCL1 cells were determined using anti-BCL1 idiotype monoclonal antibodies. The mice that died before day + 30 were not included. TCD indicates T-cell–depleted; BMCs, bone marrow cells; PDP, photodynamic cell purging process.
P < .001, compared with normal C57BL/6 and BALB/c.
P < .0001, compared with BCL1 + TCD BMC only.