Table 1.

Effect of BisI on survival of B-CLL lymphocytes

PatientViability (%)
ControlBisITPABisI + TPAIL-4BisI + IL-4
40 ± 7 36 ± 19 49 ± 0.9 42 ± 1 39 ± 5 38 ± 10 
38 ± 7 19 ± 14 77 ± 4 46 ± 20 64 ± 4 30 ± 10 
82 ± 0.4 59 ± 3 85 ± 1 77 ± 2 76 ± 1 56 ± 2 
78 ± 6 68 ± 6 68 ± 16 80 ± 8 84 ± 8 80 ± 11 
59 ± 1 47 ± 1 61 ± 0.1 51 ± 0.7 ND ND 
79 ± 1 37 ± 7 71 ± 3 57 ± 17 77 ± 0.4 29 ± 2 
68 ± 0.8 25 ± 3 66 ± 4 54 ± 30 82 ± 0.1 46 ± 1 
10 72 ± 6 66 ± 11 66 ± 2 67 ± 5 69 ± 7 65 ± 9 
11 34 ± 2 23 ± 4 53 ± 2 31 ± 3 ND ND 
12 48 ± 9 15 ± 8 71 ± 4 52 ± 7 71 ± 2 24 ± 2 
Mean ± SD 60 ± 18 39 ± 19* 67 ± 11 56 ± 15 70 ± 14 46 ± 20 
PatientViability (%)
ControlBisITPABisI + TPAIL-4BisI + IL-4
40 ± 7 36 ± 19 49 ± 0.9 42 ± 1 39 ± 5 38 ± 10 
38 ± 7 19 ± 14 77 ± 4 46 ± 20 64 ± 4 30 ± 10 
82 ± 0.4 59 ± 3 85 ± 1 77 ± 2 76 ± 1 56 ± 2 
78 ± 6 68 ± 6 68 ± 16 80 ± 8 84 ± 8 80 ± 11 
59 ± 1 47 ± 1 61 ± 0.1 51 ± 0.7 ND ND 
79 ± 1 37 ± 7 71 ± 3 57 ± 17 77 ± 0.4 29 ± 2 
68 ± 0.8 25 ± 3 66 ± 4 54 ± 30 82 ± 0.1 46 ± 1 
10 72 ± 6 66 ± 11 66 ± 2 67 ± 5 69 ± 7 65 ± 9 
11 34 ± 2 23 ± 4 53 ± 2 31 ± 3 ND ND 
12 48 ± 9 15 ± 8 71 ± 4 52 ± 7 71 ± 2 24 ± 2 
Mean ± SD 60 ± 18 39 ± 19* 67 ± 11 56 ± 15 70 ± 14 46 ± 20 

B-CLL cells were incubated for 48 hours in medium alone (control), with 10 nM TPA or 10 ng/mL IL-4, in the absence or presence of 5 μM BisI. Cell viability was determined by flow cytometry. Data are shown as the mean ± SD of 2 independent experiments performed in duplicate.

ND indicates not determined.

*

P < .005 versus control.

P < .005 versus TPA.

P < .005 versus IL-4.