Effect of BisI on survival of B-CLL lymphocytes
Patient . | Viability (%) . | |||||
---|---|---|---|---|---|---|
Control . | BisI . | TPA . | BisI + TPA . | IL-4 . | BisI + IL-4 . | |
2 | 40 ± 7 | 36 ± 19 | 49 ± 0.9 | 42 ± 1 | 39 ± 5 | 38 ± 10 |
3 | 38 ± 7 | 19 ± 14 | 77 ± 4 | 46 ± 20 | 64 ± 4 | 30 ± 10 |
4 | 82 ± 0.4 | 59 ± 3 | 85 ± 1 | 77 ± 2 | 76 ± 1 | 56 ± 2 |
5 | 78 ± 6 | 68 ± 6 | 68 ± 16 | 80 ± 8 | 84 ± 8 | 80 ± 11 |
6 | 59 ± 1 | 47 ± 1 | 61 ± 0.1 | 51 ± 0.7 | ND | ND |
7 | 79 ± 1 | 37 ± 7 | 71 ± 3 | 57 ± 17 | 77 ± 0.4 | 29 ± 2 |
9 | 68 ± 0.8 | 25 ± 3 | 66 ± 4 | 54 ± 30 | 82 ± 0.1 | 46 ± 1 |
10 | 72 ± 6 | 66 ± 11 | 66 ± 2 | 67 ± 5 | 69 ± 7 | 65 ± 9 |
11 | 34 ± 2 | 23 ± 4 | 53 ± 2 | 31 ± 3 | ND | ND |
12 | 48 ± 9 | 15 ± 8 | 71 ± 4 | 52 ± 7 | 71 ± 2 | 24 ± 2 |
Mean ± SD | 60 ± 18 | 39 ± 19* | 67 ± 11 | 56 ± 15† | 70 ± 14 | 46 ± 20‡ |
Patient . | Viability (%) . | |||||
---|---|---|---|---|---|---|
Control . | BisI . | TPA . | BisI + TPA . | IL-4 . | BisI + IL-4 . | |
2 | 40 ± 7 | 36 ± 19 | 49 ± 0.9 | 42 ± 1 | 39 ± 5 | 38 ± 10 |
3 | 38 ± 7 | 19 ± 14 | 77 ± 4 | 46 ± 20 | 64 ± 4 | 30 ± 10 |
4 | 82 ± 0.4 | 59 ± 3 | 85 ± 1 | 77 ± 2 | 76 ± 1 | 56 ± 2 |
5 | 78 ± 6 | 68 ± 6 | 68 ± 16 | 80 ± 8 | 84 ± 8 | 80 ± 11 |
6 | 59 ± 1 | 47 ± 1 | 61 ± 0.1 | 51 ± 0.7 | ND | ND |
7 | 79 ± 1 | 37 ± 7 | 71 ± 3 | 57 ± 17 | 77 ± 0.4 | 29 ± 2 |
9 | 68 ± 0.8 | 25 ± 3 | 66 ± 4 | 54 ± 30 | 82 ± 0.1 | 46 ± 1 |
10 | 72 ± 6 | 66 ± 11 | 66 ± 2 | 67 ± 5 | 69 ± 7 | 65 ± 9 |
11 | 34 ± 2 | 23 ± 4 | 53 ± 2 | 31 ± 3 | ND | ND |
12 | 48 ± 9 | 15 ± 8 | 71 ± 4 | 52 ± 7 | 71 ± 2 | 24 ± 2 |
Mean ± SD | 60 ± 18 | 39 ± 19* | 67 ± 11 | 56 ± 15† | 70 ± 14 | 46 ± 20‡ |
B-CLL cells were incubated for 48 hours in medium alone (control), with 10 nM TPA or 10 ng/mL IL-4, in the absence or presence of 5 μM BisI. Cell viability was determined by flow cytometry. Data are shown as the mean ± SD of 2 independent experiments performed in duplicate.
ND indicates not determined.
P < .005 versus control.
P < .005 versus TPA.
P < .005 versus IL-4.