Most frequently reported adverse events: safety population
| . | Frequency (% subjects reporting adverse events) . | ||
|---|---|---|---|
| Intravenous acyclovir N = 748 . | Oral acyclovir n = 307 . | Oral valacyclovir n = 311 . | |
| Nausea | 53 | 21 | 24 |
| Vomiting | 59 | 22 | 22 |
| Abdominal pain | 27 | 16 | 19 |
| Diarrhea | 45 | 21 | 19 |
| Hypertension | 21 | 11 | 13 |
| Cough | 10 | 10 | 12 |
| Headache | 28 | 14 | 12 |
| Pain | 14 | 10 | 12 |
| Kidney function abnormality | 11 | 8 | 10 |
| Rash | 21 | 10 | 10 |
| Arthralgia | 7 | 7 | 10 |
| Constipation | 11 | 3 | 5 |
| Anxiety | 13 | 3 | 4 |
| Epistaxis | 14 | 4 | 3 |
| Stomatitis | 68 | 2 | 2 |
| TMA-like episode | 1 | 2 | 3 |
| . | Frequency (% subjects reporting adverse events) . | ||
|---|---|---|---|
| Intravenous acyclovir N = 748 . | Oral acyclovir n = 307 . | Oral valacyclovir n = 311 . | |
| Nausea | 53 | 21 | 24 |
| Vomiting | 59 | 22 | 22 |
| Abdominal pain | 27 | 16 | 19 |
| Diarrhea | 45 | 21 | 19 |
| Hypertension | 21 | 11 | 13 |
| Cough | 10 | 10 | 12 |
| Headache | 28 | 14 | 12 |
| Pain | 14 | 10 | 12 |
| Kidney function abnormality | 11 | 8 | 10 |
| Rash | 21 | 10 | 10 |
| Arthralgia | 7 | 7 | 10 |
| Constipation | 11 | 3 | 5 |
| Anxiety | 13 | 3 | 4 |
| Epistaxis | 14 | 4 | 3 |
| Stomatitis | 68 | 2 | 2 |
| TMA-like episode | 1 | 2 | 3 |