Factor XI produced by baby hamster kidney cells transfected with normal and mutated recombinant complementary DNAs
| Recombinant cDNA . | No. transfections . | Factor XI secreted in medium . | Specific activity, U/mg . | Intracellular factor XI in lysate . | |
|---|---|---|---|---|---|
| Activity, U/dL . | Antigen, ng/mL . | Antigen, ng/mL . | |||
| WT | 6 | 1.45 ± 0.80 | 99 ± 47 | 146 | 187 ± 74 |
| Cys38Arg | 3 | < 0.01 | <1 | — | 138 ± 60 |
| Cys237Tyr | 4 | < 0.01 | 3.1 ± 2.2 | — | 172 ± 46 |
| Tyr493His | 3 | 0.18 ± 0.08 | 11.5 ± 3.0 | 157 | 58 ± 8 |
| Cys321Phe* | 3 | 1.32 ± 0.16 | 80 ± 8.7 | 165 | 178 ± 21 |
| Recombinant cDNA . | No. transfections . | Factor XI secreted in medium . | Specific activity, U/mg . | Intracellular factor XI in lysate . | |
|---|---|---|---|---|---|
| Activity, U/dL . | Antigen, ng/mL . | Antigen, ng/mL . | |||
| WT | 6 | 1.45 ± 0.80 | 99 ± 47 | 146 | 187 ± 74 |
| Cys38Arg | 3 | < 0.01 | <1 | — | 138 ± 60 |
| Cys237Tyr | 4 | < 0.01 | 3.1 ± 2.2 | — | 172 ± 46 |
| Tyr493His | 3 | 0.18 ± 0.08 | 11.5 ± 3.0 | 157 | 58 ± 8 |
| Cys321Phe* | 3 | 1.32 ± 0.16 | 80 ± 8.7 | 165 | 178 ± 21 |