Patient and donor characteristics
| Clinical parameter . | Patient . | |||
|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | |
| Age/sex | 58/M | 54/M | 57/M | 48/M |
| Constitutional symptoms | Fatigue, night sweats | Weight loss, fever | Fatigue, night sweats | Fatigue, early satiety |
| WBC count, × 109/L | ||||
| At diagnosis | 1.7 | 3.8 | 3.3 | 5.3 |
| Pretransplant | 1.0 | 5.2 | 3.2 | 5.0 |
| ANC, × 109/L | ||||
| At diagnosis | 0.7 | 2.2 | 1.9 | 3.6 |
| Pretransplant | 0.4 | 3.5 | 1.8 | 3.7 |
| Myelocytes and metamyelocytes in peripheral blood, % | ||||
| At diagnosis | 3 | 14 | 13 | 7 |
| Pretransplant | 4 | 10 | 10 | 3 |
| Hb level, g/dL | ||||
| At diagnosis | 5.9 | 8.4 | 11.0 | 9.0 |
| Pretransplant | 7.2‡ | 7.8‡ | 10.2 | 8.9 |
| Nucleated red blood cells in peripheral blood, % | ||||
| At diagnosis | 1 | 2 | 5 | 2 |
| Pretransplant | 1 | 1 | 1 | 1 |
| Platelet count, × 109/L | ||||
| At diagnosis | 47 | 80 | 276 | 57 |
| Pretransplant | 23 | 34 | 209 | 63 |
| Circulating blasts, % | ||||
| At diagnosis | 1 | 3 | 6 | 1 |
| Pretransplant | 1 | 9 | 6 | 1 |
| Spleen size, cm below left costal margin | ||||
| At diagnosis | NP1-153 | 4 | 14 | 4 |
| Pretransplant | NP1-153 | 6 | 18 | 5 |
| Grade of BM fibrosis* | 4 | 4 | 4 | 4 |
| Prior RBC transfusions | Yes | Yes | No | No |
| Prior RBC transfusion units | 4 | 14 | 0 | 0 |
| Risk category† | High | Int | Int | Int |
| Donor age/sex | 54/F | 46/F | 55/M | 44/F |
| CD34+ cell dose transplanted, × 106/kg | 5.0 | 7.8 | 6.8 | 3.8 |
| Clinical parameter . | Patient . | |||
|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | |
| Age/sex | 58/M | 54/M | 57/M | 48/M |
| Constitutional symptoms | Fatigue, night sweats | Weight loss, fever | Fatigue, night sweats | Fatigue, early satiety |
| WBC count, × 109/L | ||||
| At diagnosis | 1.7 | 3.8 | 3.3 | 5.3 |
| Pretransplant | 1.0 | 5.2 | 3.2 | 5.0 |
| ANC, × 109/L | ||||
| At diagnosis | 0.7 | 2.2 | 1.9 | 3.6 |
| Pretransplant | 0.4 | 3.5 | 1.8 | 3.7 |
| Myelocytes and metamyelocytes in peripheral blood, % | ||||
| At diagnosis | 3 | 14 | 13 | 7 |
| Pretransplant | 4 | 10 | 10 | 3 |
| Hb level, g/dL | ||||
| At diagnosis | 5.9 | 8.4 | 11.0 | 9.0 |
| Pretransplant | 7.2‡ | 7.8‡ | 10.2 | 8.9 |
| Nucleated red blood cells in peripheral blood, % | ||||
| At diagnosis | 1 | 2 | 5 | 2 |
| Pretransplant | 1 | 1 | 1 | 1 |
| Platelet count, × 109/L | ||||
| At diagnosis | 47 | 80 | 276 | 57 |
| Pretransplant | 23 | 34 | 209 | 63 |
| Circulating blasts, % | ||||
| At diagnosis | 1 | 3 | 6 | 1 |
| Pretransplant | 1 | 9 | 6 | 1 |
| Spleen size, cm below left costal margin | ||||
| At diagnosis | NP1-153 | 4 | 14 | 4 |
| Pretransplant | NP1-153 | 6 | 18 | 5 |
| Grade of BM fibrosis* | 4 | 4 | 4 | 4 |
| Prior RBC transfusions | Yes | Yes | No | No |
| Prior RBC transfusion units | 4 | 14 | 0 | 0 |
| Risk category† | High | Int | Int | Int |
| Donor age/sex | 54/F | 46/F | 55/M | 44/F |
| CD34+ cell dose transplanted, × 106/kg | 5.0 | 7.8 | 6.8 | 3.8 |
WBC indicates white blood cell; ANC, absolute neutrophil count; Hb, hemoglobin; BM, bone marrow; RBC, red blood cell; NP, nonpalpable; Int, intermediate.
Marrow fibrosis according to the criteria of Bauermeister.22
Risk for disease progression according to the criteria of Dupriez et al.4
Received previous RBC transfusions.
Imaging studies revealed splenomegaly.