MRD in relation to clinical parameters
| . | No. D15 . | Median MRD D15, % . | No. D29 . | Median MRD D29, % . |
|---|---|---|---|---|
| WBC count at diagnosis (× 109/L) | ||||
| Less than 10 | 26 | 0.3 | 38 | 0.01 |
| 10 to lower than 50 | 26 | 0.075 | 37 | 0.01 |
| 50 to lower than 100 | 5 | 0.01 | 11 | 0.03 |
| 100 to lower than 200 | 8 | 0.4 | 10 | 0.02 |
| 200 or more | 5 | 0.8 | 4 | 0.65 |
| Subgroup comparisons | rS = −0.13, ns | rS = 0.10, ns | ||
| Age at diagnosis, y | ||||
| 1.0 to younger than 2.0 | 6 | 0.025 | 11 | 0.01 |
| 2.0 to younger than 6.0 | 41 | 0.1 | 54 | 0.009 |
| 6.0 to younger than 10.0 | 14 | 1 | 18 | 0.03 |
| 10.0 or older | 9 | 1 | 17 | 0.2 |
| Subgroup comparisons | rS = 0.46,P < .0001 | rS = 0.32, P = .001 | ||
| Male | 43 | 0.3 | 59 | 0.02 |
| Female | 27 | 0.05 | 41 | 0.01 |
| Subgroup comparisons | ns | ns | ||
| SR | 21 | 0.3 | 29 | 0.01 |
| IR | 30 | 0.095 | 43 | 0.01 |
| HR | 19 | 0.5 | 28 | 0.035 |
| Subgroup comparisons | ns | ns | ||
| B lineage | 60 | 0.15 | 86 | 0.01 |
| T lineage | 10 | 2 | 14 | 0.35 |
| Subgroup comparisons | ns | P= .01 | ||
| Remission | 59 | 0.1 | 85 | 0.01 |
| Relapse | 11 | 1 | 15 | 0.4 |
| Subgroup comparisons | P = .03 | P = .0001 |
| . | No. D15 . | Median MRD D15, % . | No. D29 . | Median MRD D29, % . |
|---|---|---|---|---|
| WBC count at diagnosis (× 109/L) | ||||
| Less than 10 | 26 | 0.3 | 38 | 0.01 |
| 10 to lower than 50 | 26 | 0.075 | 37 | 0.01 |
| 50 to lower than 100 | 5 | 0.01 | 11 | 0.03 |
| 100 to lower than 200 | 8 | 0.4 | 10 | 0.02 |
| 200 or more | 5 | 0.8 | 4 | 0.65 |
| Subgroup comparisons | rS = −0.13, ns | rS = 0.10, ns | ||
| Age at diagnosis, y | ||||
| 1.0 to younger than 2.0 | 6 | 0.025 | 11 | 0.01 |
| 2.0 to younger than 6.0 | 41 | 0.1 | 54 | 0.009 |
| 6.0 to younger than 10.0 | 14 | 1 | 18 | 0.03 |
| 10.0 or older | 9 | 1 | 17 | 0.2 |
| Subgroup comparisons | rS = 0.46,P < .0001 | rS = 0.32, P = .001 | ||
| Male | 43 | 0.3 | 59 | 0.02 |
| Female | 27 | 0.05 | 41 | 0.01 |
| Subgroup comparisons | ns | ns | ||
| SR | 21 | 0.3 | 29 | 0.01 |
| IR | 30 | 0.095 | 43 | 0.01 |
| HR | 19 | 0.5 | 28 | 0.035 |
| Subgroup comparisons | ns | ns | ||
| B lineage | 60 | 0.15 | 86 | 0.01 |
| T lineage | 10 | 2 | 14 | 0.35 |
| Subgroup comparisons | ns | P= .01 | ||
| Remission | 59 | 0.1 | 85 | 0.01 |
| Relapse | 11 | 1 | 15 | 0.4 |
| Subgroup comparisons | P = .03 | P = .0001 |
P values for subgroup comparisons are calculated using either the Mann-Whitney U test or Kruskal-Wallis test. rS indicates Spearman rank correlation coefficient; ns, not significant.