Comparison of the cytogenetic response at 1 and 2 years
| Cytogenetic response . | After 1 y, no. (%) . | After 2 y, no. (%) . | ||
|---|---|---|---|---|
| IFN-α + LDAC . | IFN-α . | IFN-α + LDAC . | IFN-α . | |
| Nonevaluable | 81 (29) | 91 (35) | 76 (28) | 89 (34) |
| None, 0 Ph− | 51 (18) | 56 (21) | 50 (18) | 50 (19) |
| Minimal, 1%-32%, Ph− | 40 (14) | 45 (17) | 31 (11) | 42 (16) |
| Minor, 33%-65% Ph− | 44 (16) | 36 (14) | 40 (14) | 35 (13) |
| Partial, 66%-99% Ph− | 38 (14) | 28 (11) | 39 (14) | 27 (10) |
| Complete, 100% Ph− | 21 (8)* | 7 (3)* | 39 (14)† | 20 (8)† |
| Total | 275 | 263 | 275 | 263 |
| Major, 66%-100% Ph− | 59 (21)‡ | 35 (13)‡ | 78 (28)2-153 | 47 (18)2-153 |
| Cytogenetic response . | After 1 y, no. (%) . | After 2 y, no. (%) . | ||
|---|---|---|---|---|
| IFN-α + LDAC . | IFN-α . | IFN-α + LDAC . | IFN-α . | |
| Nonevaluable | 81 (29) | 91 (35) | 76 (28) | 89 (34) |
| None, 0 Ph− | 51 (18) | 56 (21) | 50 (18) | 50 (19) |
| Minimal, 1%-32%, Ph− | 40 (14) | 45 (17) | 31 (11) | 42 (16) |
| Minor, 33%-65% Ph− | 44 (16) | 36 (14) | 40 (14) | 35 (13) |
| Partial, 66%-99% Ph− | 38 (14) | 28 (11) | 39 (14) | 27 (10) |
| Complete, 100% Ph− | 21 (8)* | 7 (3)* | 39 (14)† | 20 (8)† |
| Total | 275 | 263 | 275 | 263 |
| Major, 66%-100% Ph− | 59 (21)‡ | 35 (13)‡ | 78 (28)2-153 | 47 (18)2-153 |
Data are presented as number and percentage. The response rate is calculated on all randomized cases, according to the intention-to-treat principle. The overall response rate was slightly better in the IFN-α-plus-LDAC arm than in the IFN-α arm (P = .07 at 1 year and P = .05 at 2 years, χ2test). Moreover, in the IFN-α-plus-LDAC arm, there were more complete responses (P = .009 and P = .012) and more major responses (P = .014 and P= .003).
Abbreviations are explained in Table 1.
P = .009.
P = .012.
P = .014.
P = .003.