Table 1. Matched bone marrow samples:... | American Society of Hematology

Table 1.

Matched bone marrow samples: development of mutations in the region coding for the ATP binding site of ABL during treatment of Ph⁺ ALL with STI571

Patient no.	Diagnosis	BCR-ABL mutational status prior to treatment with STI571	Response to STI571	BCR-ABL mutational status after treatment with STI571
1	Ph⁺cALL	Wild-type	PR	Glu255Lys
2	Ph⁺ cALL	Wild-type	CR	Glu255Lys
3	Ph⁺ cALL	Wild-type	CR	Wild type
4	Ph⁺ cALL	Wild-type	CR	Glu255Lys
5	Ph⁺ cALL	Wild-type	CR	Glu255Lys
14	Ph⁺ cALL	Wild-type	No	Wild type
15	Ph⁺ cALL	Wild-type	No	Glu255Lys
16	Ph⁺ pre B-ALL	Wild-type	PR	Glu255Lys
17	Ph⁺, cALL, CD33⁺	Wild-type	No	Thr315Ile

Patient no.	Diagnosis	BCR-ABL mutational status prior to treatment with STI571	Response to STI571	BCR-ABL mutational status after treatment with STI571
1	Ph⁺cALL	Wild-type	PR	Glu255Lys
2	Ph⁺ cALL	Wild-type	CR	Glu255Lys
3	Ph⁺ cALL	Wild-type	CR	Wild type
4	Ph⁺ cALL	Wild-type	CR	Glu255Lys
5	Ph⁺ cALL	Wild-type	CR	Glu255Lys
14	Ph⁺ cALL	Wild-type	No	Wild type
15	Ph⁺ cALL	Wild-type	No	Glu255Lys
16	Ph⁺ pre B-ALL	Wild-type	PR	Glu255Lys
17	Ph⁺, cALL, CD33⁺	Wild-type	No	Thr315Ile

Ph⁺ cALL indicates Philadelphia chromosome–positive common ALL (CD10⁺); PR, partial remission; CR, complete remission.