Structurally conserved regions containing the affected residues in factor VII
| SCR . | Amino acid residues . | |
|---|---|---|
| (c139-c142) . | (c180-c184) . | |
| FVII | Ser-Gly-Trp-Gly | Met-Phe-Cys-Ala-Gly |
| FX | Ser-Gly-Phe-Gly | Met-Phe-Cys-Ala-Gly |
| FIX | Ser-Gly-Trp-Gly | Met-Phe-Cys-Ala-Gly |
| PC | Thr-Gly-Trp-Gly | Met-Leu-Cys-Ala-Gly |
| UPA | Thr-Gly-Phe-Gly | Met-Leu-Cys-Ala-Ala |
| CFB | Lys-Ala-Leu-Phe | Phe-Leu-Cys-Thr-Gly |
| CF2 | Pro-Ala-His-Phe | Phe-Leu-Cys-Ser-Gly |
| CHT | Thr-Gly-Trp-Gly | Met-Ile-Cys-Ser-Gly |
| SCR . | Amino acid residues . | |
|---|---|---|
| (c139-c142) . | (c180-c184) . | |
| FVII | Ser-Gly-Trp-Gly | Met-Phe-Cys-Ala-Gly |
| FX | Ser-Gly-Phe-Gly | Met-Phe-Cys-Ala-Gly |
| FIX | Ser-Gly-Trp-Gly | Met-Phe-Cys-Ala-Gly |
| PC | Thr-Gly-Trp-Gly | Met-Leu-Cys-Ala-Gly |
| UPA | Thr-Gly-Phe-Gly | Met-Leu-Cys-Ala-Ala |
| CFB | Lys-Ala-Leu-Phe | Phe-Leu-Cys-Thr-Gly |
| CF2 | Pro-Ala-His-Phe | Phe-Leu-Cys-Ser-Gly |
| CHT | Thr-Gly-Trp-Gly | Met-Ile-Cys-Ser-Gly |
Residues c139 through c142 and c180 through c184 in chymotrypsin numbering corresponds to residues 282 through 285 and 327 through 331 in FVII.
SCR indicates structurally conserved region; FVII, factor VII; FX, factor X; FIX, factor IX; PC, protein C; UPA, urokinase plasminogen activator; CFB, complement factor B; CF2, complement factor 2; CHT, chymotrypsin.