Ex vivo thymic function and lymphocyte cell surface markers follow-up after CBT and genoidentical BMT
| Parameter . | 1 y after graft . | 2 y or more after graft . | ||||
|---|---|---|---|---|---|---|
| CBT . | BMT . | P . | CBT . | BMT . | P . | |
| TREC (per μg CD3+ DNA) | 3191 (4097) | 3935 (3879) | .57 | 10 982 (5025) | 6900 (7071) | .05 |
| Lymphocyte count | 2593 (1248) | 1974 (1238) | .32 | 2777 (971) | 2502 (1553) | .58 |
| CD3+ | 1045 (1440) | 1266 (737) | .33 | 2240 (1013) | 1695 (1043) | .44 |
| CD3+4+ | 530 (535) | 490 (365) | .90 | 1045 (556) | 817 (683) | .52 |
| CD3+8+ | 731 (875) | 760 (475) | .46 | 622 (343) | 856 (485) | .43 |
| CD3−16+56+ | 403 (276) | 252 (212) | .21 | 221 (148) | 227 (195) | .83 |
| CD3+4+28+ | 354 (425) | 423 (324) | .51 | 1045 (556) | 781 (643) | .39 |
| CD3+4−28+ | 271 (282) | 301 (219) | .85 | 524 (281) | 508 (257) | .67 |
| CD3+4+DR+ | 214 (382) | 121 (109) | .60 | 61 (36) | 78 (61) | .83 |
| CD3+4−DR+ | 408 (661) | 329 (297) | .61 | 45 (22) | 251 (172) | .05 |
| CD3+4+45ROb− | 270 (372) | 286 (290) | .41 | 766 (477) | 487 (582) | .09 |
| CD3+4+45ROb+ | 260 (228) | 204 (112) | .57 | 278 (132) | 364 (149) | .29 |
| CD3+4−45ROb− | 563 (733) | 557 (382) | .52 | 549 (351) | 593 (404) | .99 |
| CD3+4−45ROb+ | 169 (163) | 203 (151) | .58 | 73 (54) | 263 (169) | .05 |
| CD19+ | 671 (321) | 489 (533) | .27 | 518 (248) | 385 (124) | .29 |
| CD19+5+ | 246 (212) | 196 (251) | .27 | 187 (118) | 104 (49) | .22 |
| CD19+27− | 524 (277) | 454 (509) | .35 | 454 (226) | 298 (83) | .33 |
| Parameter . | 1 y after graft . | 2 y or more after graft . | ||||
|---|---|---|---|---|---|---|
| CBT . | BMT . | P . | CBT . | BMT . | P . | |
| TREC (per μg CD3+ DNA) | 3191 (4097) | 3935 (3879) | .57 | 10 982 (5025) | 6900 (7071) | .05 |
| Lymphocyte count | 2593 (1248) | 1974 (1238) | .32 | 2777 (971) | 2502 (1553) | .58 |
| CD3+ | 1045 (1440) | 1266 (737) | .33 | 2240 (1013) | 1695 (1043) | .44 |
| CD3+4+ | 530 (535) | 490 (365) | .90 | 1045 (556) | 817 (683) | .52 |
| CD3+8+ | 731 (875) | 760 (475) | .46 | 622 (343) | 856 (485) | .43 |
| CD3−16+56+ | 403 (276) | 252 (212) | .21 | 221 (148) | 227 (195) | .83 |
| CD3+4+28+ | 354 (425) | 423 (324) | .51 | 1045 (556) | 781 (643) | .39 |
| CD3+4−28+ | 271 (282) | 301 (219) | .85 | 524 (281) | 508 (257) | .67 |
| CD3+4+DR+ | 214 (382) | 121 (109) | .60 | 61 (36) | 78 (61) | .83 |
| CD3+4−DR+ | 408 (661) | 329 (297) | .61 | 45 (22) | 251 (172) | .05 |
| CD3+4+45ROb− | 270 (372) | 286 (290) | .41 | 766 (477) | 487 (582) | .09 |
| CD3+4+45ROb+ | 260 (228) | 204 (112) | .57 | 278 (132) | 364 (149) | .29 |
| CD3+4−45ROb− | 563 (733) | 557 (382) | .52 | 549 (351) | 593 (404) | .99 |
| CD3+4−45ROb+ | 169 (163) | 203 (151) | .58 | 73 (54) | 263 (169) | .05 |
| CD19+ | 671 (321) | 489 (533) | .27 | 518 (248) | 385 (124) | .29 |
| CD19+5+ | 246 (212) | 196 (251) | .27 | 187 (118) | 104 (49) | .22 |
| CD19+27− | 524 (277) | 454 (509) | .35 | 454 (226) | 298 (83) | .33 |
All lymphocyte values are presented as mean (SD) of absolute number/mm3. Mann-Whitney U test.